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METHYL 6-FORMYLNICOTINATE(CAS#10165-86-3)

Chemical Property:

Molecular Formula C8H7NO3
Molar Mass 165.15
Density 1.249
Melting Point 115-116.7 °C
Boling Point 273℃
Flash Point 119℃
pKa 1.68±0.10(Predicted)
Storage Condition under inert gas (nitrogen or Argon) at 2-8°C

Product Detail

Product Tags

Hazard Symbols Xi - Irritant
Risk Codes R37/38 - Irritating to respiratory system and skin.
R41 - Risk of serious damage to eyes
Safety Description S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S39 - Wear eye / face protection.
S36 - Wear suitable protective clothing.
HS Code 29333990
Hazard Class IRRITANT

 

Application
Methyl 6-formylnicotinate (CAS 10165-86-3) is a multifunctional heterocyclic building block featuring an aldehyde group at the 6-position and a methyl ester at the 3-position of the pyridine ring. It is widely used in medicinal chemistry for the synthesis of kinase inhibitors, antiviral agents, and antibacterial compounds. The aldehyde enables reductive amination, condensation, and Grignard additions, while the ester allows hydrolysis to the carboxylic acid or reduction to the alcohol, facilitating rapid structure-activity relationship (SAR) studies. This intermediate is a key precursor for preparing substituted nicotinic acid derivatives, pyridine-based drug candidates targeting cancer and inflammatory diseases, and agrochemicals. Its rigid pyridine core enhances metabolic stability and target binding affinity. High purity ensures reproducible results in high-throughput screening and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of methyl 6-formylnicotinate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.

 


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