5-Bromo-2-cyanobenzoic acid(CAS#1032231-28-9)
Introduction
5-Bromo-2-cyanobenzoic acid is an organic compound. The following is a brief introduction to the compound's properties, uses, preparation methods, and safety information:Quality:- Appearance: White solid- Solubility: Soluble in ketone and alcohol solvents, slightly soluble in waterUse:5-Bromo-2-cyanobenzoic acid is an important intermediate compound and is often used in organic synthesis.Method:5-Bromo-2-cyanobenzoic acid can be synthesized by the following steps:2-Cyanobenzoic acid is dissolved in acidic conditions.Add potassium bromide (KBr) to it.Stir the reaction mixture at low temperatures.Filter the pellet to obtain 5-bromo-2-cyanobenzoic acid.Safety Information:5-Bromo-2-cyanobenzoic acid may be irritating to the skin, eyes, and respiratory system. Appropriate personal protective equipment such as gloves, goggles, and face shields should be worn during handling. Safe handling and storage protocols must also be followed to avoid accidental exposure and accidents. When using or storing chemicals, please carefully read and follow the relevant safety data sheets and operating procedures.
Application
5-Bromo-2-cyanobenzoic acid (CAS 1032231-28-9) is a high-purity multifunctional building block containing a bromine, a cyano, and a carboxylic acid group on a benzene ring. This ortho-substituted pattern enables orthogonal functionalization: the carboxylic acid allows amide/ester formation, the cyano can be hydrolyzed or reduced, and the bromine participates in Suzuki-Miyaura, Buchwald-Hartwig, and Sonogashira cross-couplings. It is widely used in medicinal chemistry for the synthesis of kinase inhibitors (e.g., BCR-ABL, BTK, EGFR), PARP inhibitors, and other targeted anticancer agents. The rigid aromatic core provides metabolic stability and optimal binding affinity. This intermediate also serves in the development of antibacterial, antiviral, and anti-inflammatory drug candidates. High purity ensures reproducible results in SAR studies and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this key intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
