2,6-Dichloro-3-fluoropyridine(CAS#52208-50-1)
| UN IDs | 2811 |
| Hazard Class | 6.1 |
| Packing Group | Ⅲ |
Introduction
2,6-Dichloro-3-fluoropyridine(2,6-Dichloro-3-fluoropyridine) is an organic compound. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: 2,6-Dichloro-3-fluoropyridine is a colorless to light yellow liquid.
-Solubility: It is soluble in many organic solvents, such as alcohols and ketones, but has low solubility in water.
-Melting point: 2,6-Dichloro-3-fluoropyridine has a melting point of about 5-8°C.
-Density: Its density is about 1.60g/cm³.
Use:
- 2,6-Dichloro-3-fluoropyridine is an important organic synthesis intermediate, commonly used in the synthesis of drugs, pesticides and other organic compounds.
-It can be used as a raw material for pesticides such as plant protection agents, insecticides and fungicides.
-In the field of medicine, it can be used to synthesize a variety of drugs, such as anti-tumor drugs, antiviral drugs, etc.
Preparation Method:
- 2,6-Dichloro-3-fluoropyridine is usually prepared by adding a fluorinated reagent such as aluminum chloride, ferric chloride or hydrofluoric acid to 3-fluoropyridine, and then heating the reaction.
-In the reaction, the fluorine atom in 3-fluoropyridine is replaced by a chlorine atom, thereby obtaining a 2,6-Dichloro-3-fluoropyridine product.
Safety Information:
- 2,6-Dichloro-3-fluoropyridine is an organic compound with certain toxicity.
-Avoid direct contact with skin, eyes and clothing during handling and use.
-Adequate ventilation should be provided during operation and appropriate personal protective equipment, such as gloves, protective glasses and protective face masks should be worn.
-Keep away from fire and oxidizing agents during storage, and keep the container sealed and stored in a cool and dry place.
-For accidental contact or misuse, rinse immediately with water and seek medical attention.
Application
2,6-Dichloro-3-fluoropyridine (CAS 52208-50-1) is a multifunctional halogenated pyridine building block widely utilized in pharmaceutical and agrochemical R&D. The presence of two chlorine atoms and one fluorine atom enables sequential, regioselective nucleophilic aromatic substitution and palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira). This scaffold is a key intermediate for the synthesis of highly potent kinase inhibitors targeting cancer, inflammation, and autoimmune diseases (e.g., JAK, BTK, CDK inhibitors), as well as antiviral and antibacterial agents. In crop protection, it serves as a core precursor for developing broad-spectrum herbicides, fungicides, and insecticides with enhanced metabolic stability and environmental safety. Its electron-deficient pyridine ring improves binding affinity and bioavailability. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this versatile intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
