5-BROMO-6-METHYL INDOLE(CAS#1000343-13-4)
Introduction
5-Bromo-6-methylindole is an organic compound.Quality:5-Bromo-6-methylindole is a white to light yellow solid with a bitter taste. It is stable at room temperature, but will decompose at high temperatures. It has low solubility in solvents and can be dissolved in organic solvents such as chloroform, ethanol, methylene chloride, etc.Use:5-Bromo-6-methylindole is an important intermediate compound that is widely used in organic synthesis.Method:5-Bromo-6-methylindole is mainly prepared from indole by substitution reaction. A common method is to react indole with methyl bromide or ethyl bromide under alkaline conditions to produce 5-bromo-6-methylindole.Safety Information:5-Bromo-6-methylindole is irritating and corrosive and should be avoided from contact with the skin, eyes, and respiratory tract. Personal protective equipment such as chemical protective gloves, goggles, and face shields should be worn during handling. Care should be taken to avoid contact with oxidants and strong acids during storage and use to avoid the production of toxic gases.
Application
5-Bromo-6-methylindole (CAS 1000343-13-4) is a high-purity, halogenated indole derivative featuring bromine at the 5‑position and a methyl group at the 6‑position of the indole ring. This scaffold serves as a versatile building block in medicinal chemistry and drug discovery, particularly for the synthesis of selective IDO1 (indoleamine 2,3-dioxygenase 1) inhibitors, which are promising immunomodulatory agents for cancer immunotherapy. The bromine atom enables efficient cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) for introducing diverse aryl, heteroaryl, or alkyl substituents, facilitating rapid structure‑activity relationship (SAR) studies. This compound is also utilized in the development of antimicrobial, anticancer, and anti‑inflammatory drug candidates. Its rigid, planar indole core enhances target binding affinity and metabolic stability. High purity (≥97%) ensures reproducible results in high‑throughput screening and scalable pharmaceutical synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of 5‑bromo‑6‑methylindole with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
