6-AMINO-3,3-DIMETHYL-2-OXO-1,3-DIHYDRO-INDOLE(CAS#100510-65-4)

Introduction

6-Amino-3,3-dimethylindoline-2-one is an organic compound. The following is an introduction to its nature, use, preparation and safety information:Quality:- Appearance: 6-Amino-3,3-dimethylindoline-2-one is a white crystalline solid.- Solubility: The compound is soluble in common organic solvents such as alcohols, ethers, and esters.- Stability: 6-Amino-3,3-dimethylindoline-2-one is relatively stable at room temperature.Use:- Chemical reagents: This compound is often used as a chemical reagent and is used in organic synthesis reactions to synthesize other organic compounds.- Scientific research: due to the peculiarities of its structure, it can also be used in biomedical research and materials science.Method:The preparation method of 6-amino-3,3-dimethylindoline-2-one is generally obtained by chemical synthesis.Safety Information:The compound is relatively low toxicity to humans when used under ideal conditions, but it does not rule out the possibility of some special reactions or allergies. Proper operating procedures and safety measures should be followed when in use, such as wearing appropriate personal protective equipment (e.g., gloves, protective glasses, etc.). It should be stored in a dark, low-temperature, dry place, away from flammable materials and oxidants. To ensure safety, please read and follow the safety precautions and operating guidelines for the relevant chemicals. When actually used, it should refer to the specific safety data sheet and material safety data sheet for operation and storage.

Application
6-Amino-3,3-dimethylindolin-2-one (6-Amino-3,3-dimethyl-2-oxo-1,3-dihydro-indole, CAS 100510-65-4) is an indole derivative characterized by an amino group at the 6‑position and a gem‑dimethyl group at the 3‑position of the indolin-2-one skeleton. This heterocyclic building block has gained significant attention for its biological activities. It is a versatile reactant used in the preparation of selective and potent aminoisoquinoline derivatives as inhibitors of the mutant B‑Raf pathway, a key target in cancer therapy for melanomas and other Raf‑driven tumors. This scaffold is also utilized in the synthesis of pentacyclic aurora kinase inhibitors for oncology research. Its indolin-2-one core allows for diverse derivatization, enabling the development of focused drug‑like libraries targeting various kinase families in anticancer, anti-inflammatory, and neurological drug discovery programs. High purity ensures reproducibility in high‑throughput screening and scalable synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this key pharmaceutical intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.