5-Methoxyindole(CAS#1006-94-6)

Introduction

5-Methoxyindole is an organic compound. The following is a brief introduction to the properties, uses, preparation methods and safety information of 5-methoxyindole:Quality:- Appearance: 5-Methoxyindole is a white to light yellow crystal or crystalline powder.- Solubility: soluble in common organic solvents, such as ethanol, dimethylformamide, etc.Use:- Natural product synthesis: 5-methoxyindole can be used as an intermediate in the synthesis of natural products such as plant alkaloids.Method:The main methods for the synthesis of 5-methoxyindole are as follows:- Pyran method: pyran and sodium ethanol are used as raw materials to react under alkaline conditions to obtain 5-methoxyindole.- Functionalized substitution: Methoxy groups are introduced into the 5th position of the indole by methoxylating the indole compound.Safety Information:5-Methoxyindole has no reported toxicity and danger under normal conditions of use. As an organic compound, the following safety precautions should still be paid attention to when using:- Avoid contact with skin and eyes, and avoid inhaling their dust or gases.- Wear appropriate personal protective equipment (PPE) such as lab gloves and goggles when operating.- Operate under closed ventilation conditions to avoid the generation of harmful gases.- Waste should be disposed of in accordance with local regulations to avoid environmental pollution.

Application
5-Methoxyindole (CAS 1006-94-6) is a versatile heterocyclic building block widely used in medicinal chemistry and pharmaceutical research. As a substituted indole, it serves as a key intermediate for the synthesis of bioactive molecules, including serotonin receptor modulators (e.g., melatonin analogs), kinase inhibitors, antiviral agents, and antidepressants. The methoxy group at the 5-position enhances metabolic stability and lipophilicity, improving drug-like properties. This compound is also utilized in the production of agrochemicals, dyes, and specialty chemicals. Its indole core enables electrophilic substitution and cross-coupling reactions for further functionalization. High purity ensures reproducible results in drug discovery, SAR studies, and scalable synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 5-methoxyindole with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.