2,4-dichloroquinazoline(CAS#607-68-1)
| Hazard Class | IRRITANT |
Introduction
2,4-dichloroquinazoline(2,4-dichloroquinazoline) is an organic compound. Its chemical structure contains a quinazoline ring and two chlorine atoms in positions 2 and 4. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: 2,4-dichloroquinazoline is a colorless crystal or a white solid.
-Melting point: The melting point of the compound is about 135-137°C.
-Solubility: 2,4-dichloroquinazoline can be dissolved in some organic solvents (such as ethanol, dimethyl sulfoxide, etc.), but its solubility in water is low.
Use:
-Chemical Intermediates: 2,4-dichloroquinazoline is commonly used as an intermediate in organic synthesis. It can be used to synthesize other compounds, such as drugs, dyes and pesticides.
Preparation Method:
- 2,4-dichloroquinazoline has many preparation methods, one of which is commonly used to obtain by chlorinating 2-amino quinazoline. The specific synthetic route has multiple steps, and it is necessary to reasonably select suitable reagents and reaction conditions.
Safety Information:
- 2,4-dichloroquinazoline is generally stable under normal use conditions, but for any chemical substance, correct operating procedures and safety measures should be followed when using it.
-The compound may have a certain impact on the environment, so it should avoid its large amount of leakage into water and soil.
-During operation and storage, avoid contact with skin and eyes, and maintain good ventilation.
Application
2,4-Dichloroquinazoline (CAS 607-68-1) is a functionalized heterocyclic building block featuring a quinazoline core with two reactive chlorines at the 2- and 4-positions. It is a heterocyclic compound used as an important intermediate in pharmaceutical and fine chemical synthesis, functioning as a fundamental starting material for synthesizing novel therapeutic agents. The quinazoline ring system is a privileged scaffold in medicinal chemistry, found in numerous FDA-approved drugs, making 2,4-dichloroquinazoline a valuable precursor. The two chlorine atoms are readily replaced by other groups through nucleophilic substitution, with reactivity such that the chlorine at the 4-position can be selectively substituted first, followed by modification at the 2-position, enabling chemists to easily attach diverse functionalities and build bioactive molecules. In drug discovery, it is used to create compounds with potential anti-cancer (e.g., EGFR inhibitors, JAK2 inhibitors), antibacterial, antiviral, antifungal, anti-inflammatory, and antihypertensive properties. Its quinazoline derivatives are explored as inhibitors of various cancer pathways, including the epidermal growth factor receptor (EGFR) and neddylation pathways, targeting gastric, breast, and lung cancers. As a pharmaceutical intermediate, it serves as a crucial building block for creating complex quinazoline-based drugs and compounds with potential therapeutic benefits, including anti-Alzheimer's, anti-diabetic, and antipsychotic agents. Additionally, in the agrochemical sector, it is utilized in the production of pesticides and other agricultural chemicals, and in materials science, its low LUMO energy level enables applications in OLED fabrication as an electron-transport material core structure. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 2,4-dichloroquinazoline with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
