6-Bromo-2-methylquinazolin-4(3H)-one(CAS#5426-59-5)

Introduction

6-Bromo-2-methylquinazoline-4(3H)-one is an organic compound.The following is a description of the properties of 6-bromo-2-methylquinazolin-4(3H)-one:Appearance: Colorless crystalline solidThermal decomposition temperature: unstable and easy to decomposeSolubility: slightly soluble in water, soluble in common organic solvents such as ethanol, dimethylformamide, etcKey uses of 6-bromo-2-methylquinazolin-4(3H)-one include:Chemical reagents: used in organic synthesis reactions, especially in the field of organic chemistry for the synthesis of other compounds containing quinazoline structures.The preparation of 6-bromo-2-methylquinazoline-4(3H)-one is mainly based on the synthesis method of organic chemistry. A common method is to react with 1-bromo-2-methylquinazoline and sodium hydroxide to produce 6-bromo-2-methylquinazoline, which is then reacted with acetic anhydride to obtain the target product.

Application
6-Bromo-2-methylquinazolin-4(3H)-one (CAS 5426-59-5) is a privileged heterocyclic building block in medicinal chemistry. It serves as the core precursor for the synthesis of Raltitrexed (Tomudex), a first-line anticancer drug for treating colorectal cancer. The bromine atom at the 6-position enables efficient cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig), facilitating rapid SAR exploration to develop potent EGFR inhibitors and cytotoxic agents against cell lines like MCF-7 (breast) and SW480 (colon). This versatile scaffold also enables the development of derivatives with significant anti-inflammatory, antimicrobial, antifungal, and anticonvulsant activities. High-purity is essential for pharmaceutical and preclinical research. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this key API intermediate with flexible scaling from R&D to commercial GMP tons. Contact us today for a competitive quote and reliable global supply.