4-CHLORO-QUINAZOLINE(CAS#5190-68-1)
| Risk Codes | R25 - Toxic if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
Application
4-Chloroquinazoline (CAS 5190-68-1) is a versatile heterocyclic building block featuring a quinazoline core with a reactive chlorine at the 4-position. This key intermediate is widely used in medicinal chemistry and pharmaceutical development for the synthesis of bioactive molecules, including anticancer agents (e.g., EGFR, VEGFR, and HER2 inhibitors), antiviral drugs, anti-inflammatory compounds, and antimicrobial agents. The chlorine atom undergoes facile nucleophilic aromatic substitution with amines, alcohols, and thiols, enabling rapid construction of diverse 4-substituted quinazoline libraries for structure-activity relationship (SAR) studies. As a precursor to gefitinib, erlotinib, and other FDA-approved tyrosine kinase inhibitors, it plays a critical role in targeted cancer therapy. It also serves in agrochemical research and as a scaffold for fluorescent probes. High purity ensures reproducible results in high-throughput screening and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 4-chloroquinazoline with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
