2-Sulfobenzoic acid cyclic anhydride(CAS#81-08-3)
| Hazard Symbols | C - Corrosive |
| Risk Codes | R34 - Causes burns R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | 2923 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 21 |
| TSCA | Yes |
| HS Code | 29163900 |
2-Sulfobenzoic acid cyclic anhydride(CAS#81-08-3) Introduction
2-Thiobenzoic anhydride is also known as 2-mercaptobenzoic anhydride. The following is an introduction to its properties, uses, manufacturing methods and safety information:Quality:- Appearance: 2-Thiobenzanhydride is a colorless to pale yellow crystalline solid.- Solubility: It dissolves well in common organic solvents such as ethanol, ethers, and dimethylformamide.Use:- 2-Thiobenzoic anhydride is often used as an intermediate in organic synthesis for the preparation of other compounds. It can participate in a variety of reactions such as alkylation, nucleophilic substitution, and cyclization.Method:- 2-Thiobenzoic anhydride is generally obtained by the reaction of sulfuric acid and 2-thiobenzool. In this case, sulfuric acid and 2-thiobenzol are mixed, heated and refluxed, and then acylated. Finally, the 2-thiobenzoic anhydride product was obtained by crystallization, filtration, and drying.Safety Information:- 2-Thiobenzoic anhydride is considered a relatively safe compound under general conditions of use.- But as a chemical, it still requires proper safety measures. When using, you should pay attention to protective measures, avoid contact with skin and eyes, and maintain a well-ventilated working environment.- Relevant safety operating procedures should be followed during operation and appropriate laboratory practices should be followed.
Application
2-Sulfobenzoic acid cyclic anhydride (2-Sulfobenzoic anhydride, 3H-2,1-Benzoxathiol-3-one 1,1-dioxide, CAS 81-08-3) is a heterocyclic building block featuring a reactive cyclic anhydride fused to a sulfonyl group. As a versatile pharmaceutical intermediate and drug discovery scaffold, it participates in reactions including alkylation, nucleophilic substitution, and cyclization to produce saccharin derivatives, endothelin receptor antagonists, and other drug candidates in oncology and hematology research. In diagnostics, it is used to prepare histological staining solutions for enhanced cellular imaging. The compound functions as a multifunctional chemical intermediate in advanced organic synthesis, enabling the nickel-catalyzed synthesis of thiochromenones with near-infrared aggregation-induced emission for fluorescent probes, and as a polymer additive for flame‑retardant waterborne polyurethane coatings and carbon nanotube‑graphene composites. As a lithium‑ion battery electrolyte additive, it prevents SEI layer degradation and reduces gas generation, improving high‑temperature stability. It also serves as a polymerization inhibitor and as a biochemical tool for selective enzyme inactivation (e.g., pancreatic lipase). Xinchem offers custom synthesis and contract manufacturing of high‑purity 2‑sulfobenzoic acid cyclic anhydride with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.
