2,3-Difluorobenzoyl Chloride(CAS#18355-73-2)
| Hazard Symbols | C - Corrosive |
| Risk Codes | R34 - Causes burns R36/37 - Irritating to eyes and respiratory system. |
| Safety Description | S23 - Do not breathe vapour. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27 - Take off immediately all contaminated clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 3265 8/PG 2 |
| WGK Germany | 3 |
| HS Code | 29163990 |
| Hazard Note | Corrosive |
| Hazard Class | 8 |
| Packing Group | II |
Introduction
2,3-Difluorobenzoyl chloride is an organic compound. The following is an introduction to the properties, uses, preparation methods and safety information of 2,3-difluorobenzoyl chloride:Quality:- Appearance: 2,3-Difluorobenzoyl chloride is a colorless to pale yellow liquid.- Flammability: 2,3-difluorobenzoyl chloride is a flammable liquid whose vapours can form flammable or explosive mixtures.Use:- It can be used as an important raw material for the synthesis of other organic compounds, especially organic compounds with aromatic acyl chloride groups.Method:- 2,3-Difluorobenzoyl chloride can be prepared by the reaction of 2,3-difluorobenzoic acid with thionyl chloride. In the reaction, 2,3-difluorobenzoic acid and thionyl chloride are added to the reaction kettle at a ratio of 1:1, and the product can be obtained by stirring the reaction at an appropriate temperature for a period of time.Safety Information:- 2,3-Difluorobenzoyl chloride is an irritating substance that may have an irritating effect on the eyes and skin. Direct contact with the skin and eyes should be avoided when exposed to 2,3-difluorobenzoyl chloride, and appropriate personal protective equipment should be worn if necessary.- 2,3-difluorobenzoyl chloride is a flammable liquid and should be kept away from fire and stored in a cool, well-ventilated place.- When using 2,3-difluorobenzoyl chloride, good laboratory practice should be followed and relevant safety handling guidelines should be followed.
Application
2,3-Difluorobenzoyl chloride is a highly reactive, fluorinated aromatic acyl chloride serving as a key pharmaceutical intermediate and a versatile building block in organic synthesis. Its electron-deficient benzoyl core, activated by two fluorine atoms and a labile acyl chloride group, efficiently undergoes nucleophilic acyl substitution to construct amides, esters, and carbamates for diverse drug discovery libraries. This advanced pharmaceutical intermediate and cross-coupling acylating reagent is widely used in the synthesis of lamotrigine (anticonvulsant), antituberculosis drug candidates with potent tuberculostatic activity, benzothiazole-based antitumor agents, and highly selective enzyme inhibitors targeting xanthine oxidase. In agrochemical R&D, it serves as a versatile building block for herbicides and insecticides with improved biological activity. As a customizable fluorinated building block, it supports structure‑activity relationship (SAR) studies, high‑throughput screening, fragment‑based drug discovery (FBDD), and GMP manufacturing for APIs, agrochemicals, and specialty polymers with enhanced chemical resistance and thermal stability. Xinchem offers reliable custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 2,3-Difluorobenzoyl chloride with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and dependable global supply.
