Ethyl 2-bromooxazole-5-carboxylate(CAS#1060816-22-9)
Ethyl 2-bromooxazole-5-carboxylate(CAS#1060816-22-9)
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Organic synthesis: As an important intermediate in organic synthesis, it can be used to construct a variety of compounds containing oxazole ring structures, and has potential applications in medicinal chemistry, materials science and other fields. For example, by reacting with other reagents such as substitution and addition, different functional groups are introduced to prepare target compounds with specific biological activity or physical properties.
Pharmaceutical research: In pharmaceutical research and development, it may be used as a potential drug precursor or for the synthesis of pharmacologically active compounds. The oxazole ring structure plays an important role in many drug molecules, which can affect the binding ability and biological activity of the drug to the target, so the compound may have certain value in the research of anti-inflammatory, anti-tumor, antibacterial and other drugs.
Application
Ethyl 2-bromooxazole-5-carboxylate (CAS 1060816-22-9) is a highly functionalized heterocyclic building block widely used in medicinal chemistry and drug discovery. The bromine at the 2-position enables efficient palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira, Stille) to introduce diverse aryl, heteroaryl, or alkyl substituents, while the ethyl ester at the 5-position provides a versatile handle for hydrolysis to the carboxylic acid or reduction to the alcohol, allowing rapid diversification. This scaffold serves as a key intermediate for the synthesis of potent kinase inhibitors targeting cancer, inflammation, and autoimmune diseases (e.g., PI3K, CDK, EGFR, and BTK inhibitors), as well as antiviral, antibacterial, and antifungal agents. Its rigid, electron-deficient oxazole core enhances metabolic stability and target binding affinity, making it a privileged fragment in fragment-based drug discovery (FBDD). Additionally, it is utilized in agrochemical research and the preparation of functional materials. High purity ensures reproducible results in high-throughput screening, structure-activity relationship (SAR) studies, and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
