Oxazole, 2-chloro-4-Methyl(CAS#1060816-10-5)

Application

2-Chloro-4-methyloxazole (CAS 1060816-10-5) is a premium heterocyclic building block widely utilized as a critical pharmaceutical intermediate and synthetic scaffold in drug discovery programs. As a versatile oxazole building block, this compound serves as an essential advanced intermediate for constructing highly functionalized molecular frameworks through palladium-catalyzed cross-coupling reactions and nucleophilic aromatic substitution. The chlorine at the 2-position enables efficient Suzuki-Miyaura, Buchwald-Hartwig and Sonogashira cross-couplings for rapid structure-activity relationship (SAR) studies. Its oxazole core serves as a privileged scaffold in the design of novel therapeutics with anticancer, antiviral, antibacterial, anti-inflammatory, and neuroprotective properties. In medicinal chemistry, this halogenated methyloxazole derivative is a key intermediate for synthesizing selective kinase inhibitors, including PI3K, CDK and EGFR inhibitors for targeted oncology research. This heterocyclic building block also serves as a valuable precursor for agrochemical development (herbicides, fungicides) and functional materials. The methyl group at the 4-position provides steric and electronic modulation, enhancing metabolic stability and binding affinity. High purity ensures reproducible results in high-throughput screening, SAR studies and scalable GMP manufacturing for pharmaceutical R&D, custom synthesis projects and contract research services. Xinchem is a premier manufacturer and supplier of 2-chloro-4-methyloxazole, offering flexible custom synthesis and contract manufacturing with reliable global supply from R&D to commercial tons. Contact us today for a competitive quote.