2,4,5-Trifluorobenzyl chloride(CAS#243139-71-1)
| Risk Codes | R34 - Causes burns R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36 - Wear suitable protective clothing. |
| UN IDs | 3265 |
| Hazard Note | Corrosive |
| Hazard Class | 8 |
| Packing Group | II |
Introduction
2,4,5-Trifluorophenylmethylchloride is an organic compound. The following is an introduction to its properties, uses, manufacturing methods and safety information:Quality:- Appearance: 2,4,5-trifluorophenylmethylchloride is a colorless liquid.- Solubility: Good solubility in solvents.Use:2,4,5-Trifluorophenylmethylchloride has a variety of applications in the field of chemistry:- As a preservative: With its bactericidal and antibacterial properties, it can be used as a preservative, extending the shelf life of some products.- As a raw material: It can be used as a raw material for the synthesis of organic compounds, which is widely used in pharmaceuticals and pesticides.Method:There are various methods for the preparation of 2,4,5-trifluorophenylmethyl chloride, and the following is one of the commonly used methods:2,4,5-trifluorobenzaldehyde is reacted with a certain amount of chloroacetyl chloride, and the product is chlorinated through an acid catalyst to generate 2,4,5-trifluorophenylmethyl chloride.Safety Information:- 2,4,5-Trifluorophenylmethyl chloride is an organic compound that should be operated in a well-ventilated area and avoid inhalation or contact with skin and eyes.- When handling and storing, follow appropriate safety protocols and use personal protective measures such as protective gloves, protective eyewear and respiratory protective equipment.- During use, avoid contact with fire sources to prevent fire or explosion.- In case of accidental contact or inhalation of the substance, immediately rinse with clean water or take the injured person to a medical facility.
Application
2,4,5-Trifluorobenzyl chloride (CAS 243139-71-1) is a highly reactive fluorinated benzyl halide building block used in organic synthesis, medicinal chemistry, and process R&D. As a key pharmaceutical intermediate, this chloromethylated fluorobenzene is primarily utilized in the large‑scale synthesis of sitagliptin (Januvia®), a blockbuster DPP‑4 inhibitor for type 2 diabetes, as well as other gliptin analogs and fluoroquinolone antibiotics. The three fluorine atoms enhance drug metabolic stability, lipophilicity, and bioavailability. In crop protection, it is used to prepare modern herbicides, fungicides, and insecticides. In materials science, the compound can be grafted onto polymer backbones to improve chemical resistance, thermal stability, and surface hydrophobicity for advanced coatings, sealants, and high‑performance polymers. Xinchem offers reliable custom synthesis, custom chemical synthesis, and contract manufacturing of this high‑purity fluorinated intermediate with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and dependable global supply.
