1-(CHLOROMETHYL)-2,3,4-TRIFLUOROBENZENE(CAS#292621-60-4)
Introduction
2,3,4-TRIFLUOROBENZYL CHLORIDE IS AN ORGANIC COMPOUND, AND ITS ENGLISH NAME IS 1-(CHLOROMETHYL)-2,3,4-TRIFLUOROBENZENE.Quality:2,3,4-Trifluorobenzyl chloride is a solid with colorless or yellowish crystals. It has a strong odor. 2,3,4-Trifluorobenzyl chloride is insoluble in water and can be soluble in organic solvents such as ethanol and ether.Use:2,3,4-Trifluorobenzyl chloride can be used as an intermediate in the field of organic synthesis.Method:2,3,4-Trifluorobenzyl chloride can be synthesized by reacting 2,3,4-trifluorobenzyl chloride with chloromethane. The specific manufacturing method can refer to the relevant organic synthesis literature or patents.Safety Information: It is a hazardous substance that can cause harm to the human body and the environment. Wear appropriate personal protective equipment during use and avoid contact with skin, eyes, and respiratory tract. When storing and handling, pay attention to fire and explosion protection, and comply with relevant safety operation specifications.
Application
1-(Chloromethyl)-2,3,4-trifluorobenzene (2,3,4-Trifluorobenzyl chloride) is a versatile fluorinated building block widely employed as a key pharmaceutical intermediate in the synthesis of active pharmaceutical ingredients (APIs). Its reactive chloromethyl group enables efficient nucleophilic substitution and cross‑coupling reactions, making it a critical precursor for the production of fluoroquinolone antibiotics, notably levofloxacin and ofloxacin, as well as other antibacterial and antifungal agents. The trifluorinated benzene ring enhances the metabolic stability, lipophilicity, and bioavailability of drug candidates. Beyond pharmaceuticals, this compound serves as an essential agrochemical intermediate for the preparation of selective herbicides, insecticides, and fungicides with improved efficacy and environmental safety. It also functions as a versatile building block in the synthesis of high‑performance materials, including specialty polymers, liquid crystals, and coatings, imparting exceptional thermal and chemical resistance. Xinchem offers reliable custom synthesis, custom chemical synthesis, and contract manufacturing of this high‑purity trifluorobenzyl chloride, with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and dependable global supply.
