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2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(CAS#90213-66-4)
| Hazard Symbols | T - Toxic |
| Risk Codes | R25 - Toxic if swallowed R36 - Irritating to the eyes R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S28 - After contact with skin, wash immediately with plenty of soap-suds. S36 - Wear suitable protective clothing. |
| UN IDs | UN2811 |
| HS Code | 29335990 |
| Hazard Class | IRRITANT |
Introduction
2,4-Dichloro-7Hpyrrole [2,3-D]pyrimidine is a nitrogen heterocyclic compound containing a dichloride group. It has a colorless to yellow crystalline solid. The following is an introduction to its nature, use, preparation method and safety information:Quality:- Appearance: Colorless to yellow crystalline solid- Solubility: almost insoluble in water and soluble in organic solventsUse:- 2,4-Dichloro-7Hpyrrole[2,3-D]pyrimidine is a commonly used pesticide intermediate for the synthesis of compounds such as pesticides, insecticides, and herbicides.- It can also be used as a reagent in scientific laboratories.Method:- 2,4-dichloro-7Hpyrrole [2,3-D]pyrimidine can be obtained by reacting 2,4-dichloropyridine and urea under suitable conditions.Safety Information:- 2,4-Dichloro-7Hpyrrole[2,3-D]pyrimidine is an organic compound with certain toxicity. Appropriate safety precautions, such as gloves, goggles, and protective clothing, should be taken when using or handling.- Avoid inhaling its powder or vapor and keep away from open flames and high temperatures.- Avoid contact with strong oxidizing agents and strong acids.- Comply with relevant regulations and guidelines during storage and handling.
Application
2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine (CAS 90213-66-4) is a key heterocyclic intermediate widely used in pharmaceutical research and development. Its fused pyrrolo-pyrimidine core with two reactive chloro groups enables sequential nucleophilic substitution and cross-coupling reactions, making it a versatile scaffold for constructing diverse libraries of kinase inhibitors targeting cancer, inflammation, and autoimmune diseases (e.g., JAK, BTK, CDK). This compound serves as a purine bioisostere, allowing rapid SAR exploration through selective functionalization at the 2- and 4-positions. It is also utilized in agrochemical synthesis and material science. High purity ensures reproducibility in complex synthetic routes. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
