3,4-Difluorophenol(CAS#2713-33-9)
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R34 - Causes burns R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable R21/22 - Harmful in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S16 - Keep away from sources of ignition. |
| UN IDs | UN 1325 4.1/PG 2 |
| WGK Germany | 3 |
| HS Code | 29081000 |
| Hazard Note | Irritant |
| Hazard Class | 4.1 |
| Packing Group | II |
Introduction
3,4-Difluorophenol, also known as 2,3-difluorohydroxidebenzene, is an organic compound. The following is an introduction to the properties, uses, preparation methods and safety information of 3,4-difluorophenol:- Properties:- Appearance: colorless crystalline or light yellow solid. - Solubility: Slightly soluble in water, soluble in organic solvents such as ethanol, ethers and chlorinated hydrocarbons. Uses:- It also has antiseptic and bactericidal properties, and can be used for the antiseptic of wood and textiles. Preparation method: - 3,4-difluorophenol can be prepared by the reaction of phenol and hydrofluoric acid. The reaction conditions can be adjusted on a case-by-case basis. Safety Information:- 3,4-Difluorophenol is a toxic compound and should be handled with caution. - When using and storing, avoid contact with strong oxidizing agents, strong acids and strong bases. - When in contact with skin, eyes, or mucous membranes, rinse immediately with plenty of water. - Maintain good ventilation during operation and follow relevant safety operating procedures. - When handling 3,4-difluorophenol, wear appropriate personal protective equipment such as gloves, goggles, and protective clothing.
Application
3,4-Difluorophenol (CAS 2713-33-9) is a high-purity fluorinated phenolic building block widely used in pharmaceutical, agrochemical, and material science research. Its electron-withdrawing fluorine atoms enhance metabolic stability, lipophilicity, and binding affinity of drug candidates. This versatile intermediate serves as a key precursor for the synthesis of fluoroquinolone antibiotics (e.g., norfloxacin, ciprofloxacin), antifungal agents, and kinase inhibitors for oncology and inflammatory diseases. In agrochemical development, it is utilized to prepare selective herbicides (e.g., aryloxyphenoxypropionates), fungicides, and insecticides with improved crop protection profiles. The phenolic hydroxyl enables etherification, esterification, and cross-coupling reactions, allowing rapid structure-activity relationship studies. Additionally, 3,4-difluorophenol is employed in the production of liquid crystal display materials, specialty polymers, and functional coatings. High purity ensures reproducible results in high-throughput screening, SAR studies, and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
