4-(2-METHYLPROPOXY)-BENZENEMETHANAMINE(CAS#4734-09-2)

Introduction

4-Isobutoxybenzylamine, also known as 4-(2-methylpropoxy)aniformide, is an organic compound.Quality:- Appearance: Colorless to light yellow transparent liquid- Solubility: Soluble in ethers, alcohols and ketone solvents, slightly soluble in waterUse:4-Isobutoxybenzylamine is often used as an intermediate in organic synthesis.Method:There are relatively many preparation methods for 4-isobutoxybenzylamine, and a commonly used preparation method is to condense p-toluene methanol and 2-methacrylate under appropriate conditions.Safety Information: Avoid contact with skin, eyes and mucous membranes, and wear protective gloves and glasses when operating. In case of accidental inhalation or ingestion, seek medical attention immediately. Make sure to operate in a well-ventilated area and avoid contact with fire. Detailed safety information can be found in the relevant safety data sheet for this compound.

Application

4-(2-Methylpropoxy)-benzenemethanamine (4-Isobutoxybenzylamine, CAS 4734-09-2) is a high‑purity, versatile pharmaceutical intermediate and advanced organic building block. It serves as the key synthetic precursor and essential pharmaceutical intermediate for the large‑scale manufacture of Pimavanserin (Nuplazid), a first‑in‑class selective serotonin 5‑HT₂A receptor inverse agonist used as a clinically approved API for treating hallucinations and delusions associated with Parkinson’s disease psychosis, and as an active anti‑psychotic drug candidate for Alzheimer’s disease psychosis, schizophrenia, and agitation research. Beyond CNS drug discovery, this benzylamine derivative is widely employed as a multi‑functional coupling precursor and research reagent in medicinal chemistry, enabling reductive amination, carbamate urea formation, ammonolysis, and cross‑coupling transformations for the efficient synthesis of substituted benzylamine libraries, building blocks for protease inhibitors, and drug conjugates for oncology and metabolic disease programs. Additionally, it supports agrochemical intermediate development, serves as a versatile organic synthesis reagent for heterocyclic compound preparation, and functions as a functional material synthesis monomer for polymers, coatings, and specialty fine chemicals. Xinchem is a premier manufacturer and reliable supplier offering flexible custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 4-(2-Methylpropoxy)-benzenemethanamine with comprehensive characterization (COA, HPLC, MS), full regulatory documentation, and reliable global supply, flexibly scaled from R&D grams to commercial metric tons for all your research, development, and production needs. Contact us today for a competitive quote.