4-AMINO-5-BROMOPYRROLO[2,3-D]PYRIMIDINE(CAS#22276-99-9)

Introduction

4-Amino-5-bromopyrrolo[2,3-D]pyrimidine is an organic compound. The following is an introduction to its nature, use, manufacturing methods and safety information:Quality:- Appearance: 4-amino-5-bromopyrrolo[2,3-D]pyrimidine is a colorless crystalline solid.- Solubility: Soluble in some organic solvents, such as methanol, ethanol, acetone, etc.Use:Method:- A method for the synthesis of 4-amino-5-bromopyrrole[2,3-D]pyrimidine is to react with sodium nitrite of a nitro derivative of benzo[2,3-D]pyrimidine, and then treat it with ammonia to obtain the target product.Safety Information:- 4-Amino-5-bromopyrrolo[2,3-D]pyrimidine has limited toxicity and safety information, and appropriate precautions should be taken when using and handling it.- When using the compound in the laboratory, wear chemical protective glasses and gloves and ensure that it is operated in a well-ventilated area.- When storing and handling the compound, care should be taken to ensure its stability and avoid contact with ignition sources.- Comply with relevant laws and regulations and safe practices when using or disposing of the compound.

Application
4-Amino-5-bromopyrrolo[2,3-d]pyrimidine (CAS 22276-99-9) is a versatile heterocyclic scaffold that serves as a purine bioisostere. It is widely used in medicinal chemistry for the synthesis of kinase inhibitors, particularly targeting Janus kinases (JAK), Bruton’s tyrosine kinase (BTK), and cyclin‑dependent kinases (CDK) in oncology and inflammatory disease research. The amino group enables amide or urea formation, while the bromine atom facilitates cross‑coupling reactions such as Suzuki‑Miyaura, Buchwald‑Hartwig, and Sonogashira for late‑stage diversification. This building block is essential for constructing drug‑like libraries and lead optimization campaigns. Xinchem offers custom synthesis and contract manufacturing of high‑purity this compound with flexible scaling from R&D to commercial quantities. Contact us today for a competitive quote and reliable global supply.