4-Pyridazinamine(CAS#20744-39-2)
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
Application
4-Pyridazinamine (4-Aminopyridazine, CAS 20744-39-2) is a versatile heterocyclic building block widely used in pharmaceutical R&D, agrochemical synthesis, and material science. In drug discovery, it serves as a key pharmaceutical intermediate for the synthesis of selective PDE10A inhibitors with reduced CYP1A2 inhibition, ATP-competitive PI3K/mTOR dual inhibitors for oncology research, and SMARCA2/4 degraders targeting cancer pathways. As a valuable pyridazine scaffold, it enables rapid structure-activity relationship (SAR) studies through amide coupling, cross-coupling reactions, and nucleophilic substitution. Its derivatives exhibit significant herbicidal activity against weeds such as Echinochloa crus-galli and Eleusine indica, making it an essential agrochemical intermediate for crop protection. In advanced materials, it is incorporated into polymer formulations to improve mechanical properties and thermal stability of coatings and adhesives. It also functions as an analytical reagent in chromatography and spectrometry, as well as a precursor for fluorescent probes and corrosion inhibitors. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 4-pyridazinamine with a global supply network. Our flexible production scales from R&D samples to commercial tons, ensuring consistent quality and reliable delivery for pharmaceutical, agrochemical, and industrial applications. Contact us today for a competitive quote.
