5-Bromo-2-fluorobenzotrifluoride(CAS#393-37-3)
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S23 - Do not breathe vapour. S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37 - Wear suitable gloves. |
| WGK Germany | 3 |
| HS Code | 29039990 |
| Hazard Class | IRRITANT |
Introduction
It is an organic compound. Its molecular formula is C7H3BrF4 and its molecular weight is 247.99g/mol. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: colorless liquid
-Melting point:-4 ℃
-Boiling point: 140-142 ℃
-Stability: Stable when in contact with air, but avoid direct sunlight and high temperature.
Use:
-is mainly used as a catalyst and raw material in organic synthesis.
-It can be used to synthesize organic compounds such as drugs and pesticides.
Preparation Method:
-fluorobenzene can be prepared by the reaction of 5-bromo-2-fluorobenzene (5-Bromo-2-fluorobenzene) and trifluorotoluene (Trifluorotoluene).
-The reaction conditions are usually carried out in an organic solvent under an inert atmosphere.
Safety Information:
-irritant to the eyes, skin and respiratory tract, contact with the need to pay attention to personal protection.
-Avoid inhalation or contact with skin before use, and wear appropriate protective equipment (such as gloves, goggles and protective clothing) before use.
-Avoid contact with oxidants and strong acids during storage and handling to reduce safety risks.
Application
5-Bromo-2-fluorobenzotrifluoride (CAS 393-37-3) is a multifunctional halogenated arene featuring bromine, fluorine, and a trifluoromethyl group. Its electron-withdrawing substituents activate the aromatic ring for regioselective nucleophilic aromatic substitution (SNAr) and enable efficient palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira). This building block is widely used as a key pharmaceutical intermediate for the synthesis of kinase inhibitors, antiviral agents, and central nervous system (CNS) drug candidates. In agrochemical research, it serves as a precursor for modern herbicides, fungicides, and insecticides with improved metabolic stability and bioavailability. The trifluoromethyl group enhances lipophilicity and membrane permeability, while the bromine provides a versatile handle for further functionalization. It is also employed in the production of liquid crystal display (LCD) materials, organic light-emitting diodes (OLEDs), and specialty polymers. High purity ensures reproducible results in structure-activity relationship (SAR) studies, high-throughput screening, and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
