9-Hydroxynonanoic acid(CAS#3788-56-5)

Introduction

9-HYDROXYNONANOIC ACID is an organic compound with the chemical formula C9H18O3. The following is a description of the nature, use, preparation and safety information of 9-HYDROXYNONANOIC ACID:

Nature:

-Appearance: 9-HYDROXYNONANOIC ACID is a colorless or slightly yellow oily liquid.

-Solubility: It is soluble in organic solvents such as ethanol, methanol and Ether solvents, but insoluble in water.

Use:

-Chemical intermediate: 9-HYDROXYNONANOIC ACID can be used as an intermediate for the synthesis of other organic compounds.

-Surfactant: It can be used to prepare surfactants, such as emulsifiers, wetting agents and dispersants.

-Pharmaceutical preparations: 9-HYDROXYNONANOIC ACID can be used as part of a pharmaceutical formulation.

Method:

There are many ways to prepare 9-HYDROXYNONANOIC ACID, one of which is commonly used by the hydrogenation and oxidation reaction of octanal. The specific steps are as follows:

1. Octanal and hydrogen peroxide are reacted in the presence of a catalyst.

2. During the reaction, by controlling the reaction temperature and reaction time, the octyl aldehyde is hydrogenated to generate 9-hydroxynonanol.

3. 9-hydroxynonanol is oxidized by ACID catalysis to obtain 9-HYDROXYNONANOIC ACID.

Safety Information:

9-HYDROXYNONANOIC ACID is generally safe for proper use and storage. However, it may cause irritation to the eyes, skin and respiratory tract. Therefore, it is necessary to pay attention to personal protective measures, such as wearing protective glasses, gloves and respiratory protection equipment. In case of contact or inhalation, immediately flush the affected area with plenty of water and seek medical help. In addition, the storage should be away from the fire and oxidant, avoid contact with strong acid or alkali.

Application
9-Hydroxynonanoic acid (9-HNA; CAS 3788-56-5), an ω-hydroxy medium-chain fatty acid, serves as a versatile building block in the synthesis of biodegradable polymers, surface-active agents, and fine chemicals. This omega-hydroxy fatty acid intermediate is used as a monomer to produce bio-based polyester polyols for shape-memory thermoplastic polyurethanes (TPUs) for biomedical and environmentally sustainable applications. In drug delivery, 9-HNA functions as a PROTAC linker, enabling the synthesis of heterobifunctional molecules for targeted protein degradation, and is used in the development of lipid nanoparticles (LNPs) to encapsulate and stabilize nucleic acid-based therapeutics such as mRNA vaccines (mRNA vaccine stabilizer), as well as in the design of lipid-based delivery systems. In the pharmaceutical industry, 9-Hydroxynonanoic acid is a key intermediate for antifungal drug synthesis (voriconazole derivatives) and anti-inflammatory APIs, where it enhances solubility and bioavailability. In agrochemicals and cosmetics, this ω-hydroxy acid is used as a co-surfactant, wetting agent, dispersant, and natural moisturizer to improve product texture, stability, and skin feel. As a pure compound, 9-HNA is a certified analytical standard for the quantification of Mupirocin Impurity 7 in pharmaceutical quality control (QC) and method validation (MV). Xinchem offers flexible custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 9-hydroxynonanoic acid to meet customer‑specified volumes and quality standards. Contact us for a competitive quote and reliable global supply.