Diethyl(2-oxopropyl)phosphonate(CAS#1067-71-6)
Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29319090 |
1067-71-6 - Reference Information
| application | diethyl acetone phosphonic acid is an organophosphorus compound. organophosphorus compound is a kind of important chemical substance, showing many excellent properties and is widely used in agriculture, medicine, industry, etc. |
| synthesis | the synthesis steps of diethyl acetonylphosphonate are as follows:S1, add 5kg of triethyl phosphite to the reaction kettle, add 2kg of chloroacetone, reflow reaction at 120 ℃ for 7 hours, reduce and evaporate excess triethyl phosphite to obtain phosphorus salt;
S2, add the phosphorus salt obtained in step S1 to the reaction kettle, add 15L tetrahydrofuran to dissolve, cool to 0 ℃, add 1.3kg 60% sodium hydride in batches, and stir for 30 minutes to obtain diethyl acetonylphosphonate. |
Application
Diethyl(2-oxopropyl)phosphonate (CAS 1067-71-6) is a versatile ketophosphonate widely used as a Horner-Wadsworth-Emmons (HWE) reagent for the stereoselective synthesis of α,β-unsaturated ketones, esters, and nitriles. It serves as a key building block in pharmaceutical research for the construction of complex natural products and drug candidates, including anti-inflammatory and anticancer agents. In agrochemical development, it is employed as an intermediate for the synthesis of herbicides, fungicides, and insecticides. The reactive phosphonate group allows efficient olefination under mild basic conditions, offering excellent E-selectivity. Its ketone functionality further enables derivatization via reductions or condensations. High purity ensures reproducible results in medicinal chemistry, process development, and GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity Diethyl(2-oxopropyl)phosphonate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
