5-bromo-4-methylthiazole(CAS#111600-83-0)

Introduction

5-Bromo-4-methylthiazole is an organic compound. The following is an introduction to its properties, uses, manufacturing methods and safety information:Quality:5-Bromo-4-methylthiazole is a colorless to light yellow solid that is stable at room temperature. It has a strong pungent odor and is soluble in some organic solvents such as ethanol and methylene chloride.Use:5-Bromo-4-methylthiazole has a wide range of applications in organic synthesis. It can also be used as an analytical reagent and a reagent in research areas.Method:5-Bromo-4-methylthiazole can be prepared by reacting 4-methylthiazole with bromine. This reaction is usually carried out in an inert atmosphere, with the addition of bromine in an appropriate solvent and at the appropriate reaction temperature. After the reaction is complete, the product can be purified by methods such as crystallization or extraction.Safety Information:Safety information of 5-bromo-4-methylthiazole: the following points need to be focused:The compound has a pungent odor and care should be taken to avoid inhalation or contact with eyes, skin and mucous membranes.Appropriate protective equipment such as gloves, goggles, and protective clothing should be worn when using or handling9.5-Bromo-4-methylthiazole is a hazardous chemical and must be stored and handled in accordance with appropriate safety operating procedures.When discarding waste, it should be classified as hazardous waste according to local regulations and disposed of in accordance with the relevant regulations.

Application
5-Bromo-4-methylthiazole is a versatile heterocyclic building block widely used in medicinal chemistry and drug discovery. The bromine at the 5-position enables efficient palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) to introduce diverse aryl, heteroaryl, or alkyl groups, while the methyl group at the 4-position provides steric and electronic modulation. This scaffold serves as a key intermediate for the synthesis of kinase inhibitors targeting cancer, inflammation, and autoimmune diseases (e.g., JAK, BTK, CDK inhibitors), as well as antiviral, antibacterial, and antifungal agents. Its rigid thiazole core enhances metabolic stability and target binding affinity. High purity ensures reproducible results in high-throughput screening, SAR studies, and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.