5-Methoxyisoquinoline（CAS# 90806-58-9)
Introduction
5-Methoxyisoquinoline is an organic compound. It is a yellow solid that is soluble in organic solvents such as ethanol and methylene chloride.
It can be used as an intermediate in organic synthesis for the synthesis of other compounds and has certain pharmacological activity. It is also used to study biological activity, pathology, etc.
The preparation of 5-methoxyisoquinoline can be obtained by the reaction of isoquinoline and methoxybromide. The specific synthesis method can be to react isoquinoline with methoxybromide to obtain the product in the presence of alkaline conditions, and obtain the target product through purification.
Safety information: 5-Methoxyisoquinoline is an organic compound with certain toxicity. When using and storing, it is necessary to follow relevant safety operating procedures, such as wearing protective gloves and glasses, and ensure that it is operated in a well-ventilated environment. Contact with strong oxidizing agents should be avoided, and inhalation and ingestion should be avoided.
Application
5-Methoxyisoquinoline (CAS 90806-58-9) is a heteroaromatic organic compound featuring a methoxy group at the 5-position of the isoquinoline core. As a versatile research building block and synthetic intermediate, it is primarily utilized in pharmaceutical development as a key precursor in the synthesis of hepatitis C virus (HCV) NS3/4A protease inhibitors. The 5-methoxy substitution confers distinct solvation energetics and physicochemical properties compared to other isomers, making it essential for QSAR model validation and targeted structure-activity relationship (SAR) programs. Beyond antiviral research, this compound is also explored for its potential antimicrobial and anticancer properties. It undergoes various chemical transformations including oxidation to quinoline derivatives and reduction to tetrahydroisoquinoline derivatives. Available at purities of 95% to 97%, it typically exists as a yellow to brown solid soluble in organic solvents such as ethanol and dichloromethane. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 5-Methoxyisoquinoline with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.
