6-BROMO-4-CHLORO-2-METHYL-QUINAZOLINE(CAS#351426-04-5)
6-BROMO-4-CHLORO-2-METHYL-QUINAZOLINE(CAS#351426-04-5)
As an organohalogenated heterocyclic compound, it may be solid at room temperature and pressure, soluble in some common organic solvents, such as dichloromethane, N,N-dimethylformamide, etc., and has poor solubility in water.
Uses: It is an important intermediate in organic synthesis. In the field of medicinal chemistry, it may be used to synthesize quinazoline drug molecules with potential biological activity, and the bromine, chlorine atoms and functional groups such as methyl groups in their structure can be modified by various chemical reactions, so as to introduce different pharmacophores to obtain compounds with specific pharmacological effects, such as antibacterial, antitumor, antiviral and other active drugs. In materials science, it is also possible to prepare organic materials with special properties, such as optoelectronic materials, through further derivatization reactions.
Safety Information: This substance may be irritating and toxic. Avoid inhaling its dust or vapors and avoid contact with skin and eyes when using. Operate in a well-ventilated environment, and it is recommended to wear appropriate protective equipment such as gloves, goggles, and masks. In case of accidental contact, rinse immediately with plenty of water and seek medical help promptly.
Application
6-Bromo-4-chloro-2-methylquinazoline (CAS 351426-04-5) is a multifunctional dihalogenated quinazoline derivative bearing a methyl group at the 2-position. This heterocyclic building block is widely used in medicinal chemistry for the synthesis of potent tyrosine kinase inhibitors (e.g., EGFR, HER2, VEGFR, and BTK inhibitors) targeting various cancers. The chlorine at C4 undergoes selective nucleophilic aromatic substitution, while the bromine at C6 enables orthogonal palladium-catalyzed cross-couplings (Suzuki, Buchwald-Hartwig, Sonogashira), allowing rapid construction of diverse quinazoline libraries for SAR studies. The C2-methyl group enhances metabolic stability and target selectivity. It is also utilized in agrochemical research and as a precursor for fluorescent probes. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis and contract manufacturing of this key API intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
