4,6-DICHLORO-2-METHYLQUINAZOLINE(CAS#338739-44-9)

Introduction

4,6-Dichloro-2-methylquinazoline is an organic compound.4,6-Dichloro-2-methylquinazoline is often used as a starting material or intermediate in organic synthesis reactions. It can be used to synthesize a variety of organic compounds containing quinazoline structures.There are several ways to prepare 4,6-dichloro-2-methylquinazoline. A common method is to react 2-methylquinazoline with chlorine gas, introducing chlorine atoms at positions 2 and 4 by chlorination.Safety information: 4,6-dichloro-2-methylquinazoline is a toxic substance, and precautions should be taken when exposed to it. Direct contact with the skin, eyes, and respiratory tract should be avoided. Appropriate protective gloves, glasses, and masks should be worn when in use. It should be done in a well-ventilated area and personal hygiene should be enhanced.

Application
4,6-Dichloro-2-methylquinazoline (CAS 338739-44-9) is a key heterocyclic intermediate featuring two reactive chlorine atoms at the 4- and 6-positions and a methyl group at the 2-position. It is widely used in medicinal chemistry for the synthesis of potent tyrosine kinase inhibitors (e.g., EGFR, HER2, and VEGFR inhibitors) targeting non-small cell lung cancer, breast cancer, and other malignancies. The chlorine at C4 undergoes selective nucleophilic substitution, while the C6 chlorine enables cross-coupling reactions, allowing rapid structure-activity relationship (SAR) exploration. This scaffold is also utilized in the development of antiviral, anti-inflammatory, and antimicrobial agents. High purity ensures reproducible results in drug discovery and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this API intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.