6-BroMo-4-hydroxyquinolin-2(1H)-one(6-BroMo-4-hydroxyquinolin-2(1H)-one)(CAS#1379330-67-2)
Introduction
6-BroMo-4-hydroxyquinolin-2(1H)-one is a chemical compound.Quality:6-BroMo-4-hydroxyquinolin-2(1H)-one is a solid with a light yellow crystalline appearance. It is soluble in organic solvents, such as methanol, ethanol, and dimethyl sulfoxide, among others. The compound is stable in air but sensitive to strong oxidizing agents.Use:Method:A variety of approaches can be taken to prepare 6-BroMo-4-hydroxyquinolin-2(1H)-one. A commonly used method is synthesized by benzoylation of 4-hydroxy-6-bromoquinoline. The specific steps include reacting 4-hydroxy-6-bromoquinoline with benzoyl chloride in the presence of hydrochloric acid to generate 6-BroMo-4-hydroxyquinolin-2(1H)-one.Safety Information:Safety information for 6-BroMo-4-hydroxyquinolin-2(1H)-one is currently lacking. When handling and use, follow general chemical laboratory practice practices and wear appropriate personal protective equipment such as protective eyewear and gloves. It should be kept in a dry, well-ventilated place, away from fire and oxidants. Please read and understand the relevant safety manuals and technical information carefully before use.
Application
6-Bromo-4-hydroxyquinolin-2(1H)-one (CAS 1379330-67-2) is a brominated quinolinone derivative belonging to the 4-hydroxy-2-quinolone class. It is characterized by a bromine atom at the 6‑position, a hydroxyl group at the 4-position, and a keto group at the 2-position, which form a rigid, planar structure with hydrogen bond donor/acceptor sites. This scaffold is of significant interest in medicinal chemistry as a fragment for drug discovery, providing a structural basis for novel candidate design, fragment-based lead generation, and pharmaceutical intermediate synthesis. The bromine atom enables efficient cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) and nucleophilic aromatic substitution for rapid structure-activity relationship studies. This building block is utilized in the development of kinase inhibitors and as a versatile synthetic intermediate for C–H functionalization and agrochemical research. The compound is a solid with light yellow crystalline appearance, soluble in organic solvents (methanol, ethanol, DMSO), stable in air but sensitive to strong oxidizing agents. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 6-Bromo-4-hydroxyquinolin-2(1H)-one with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
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