4-BROMO-8-HYDROXYQUINOLINE(CAS#139399-63-6)

Introduction

4-Bromo-8-hydroxyquinoline is an organic compound. It is a solid and has yellow crystals. The following is an introduction to the properties, uses, preparation methods and safety information of 4-bromo-8-hydroxyquinoline:Quality:- Appearance: Yellow crystalline solid- Solubility: Low solubility among common solvents- Acidity-alkaline: Weakly acidicUses: It can also be used as an intermediate in organic optoelectronic materials, dyes and antioxidants.Method:- 4-Bromo-8-hydroxyquinoline can be obtained by bromination of 8-hydroxyquinoline. In the reaction, 8-hydroxyquinoline is reacted with brominating agents, usually using ferrous sulfate and hydrochloric acid as catalysts.- Reaction equation: 8-hydroxyquinoline + brominating agent → 4-bromo-8-hydroxyquinoline + by-product- After the reaction, a pure product is obtained by steps such as crystallization and purification.Safety Information:- This compound may cause irritation and damage to the eyes, skin, and respiratory tract and should be used with appropriate precautions.- Avoid direct contact with the skin, if it is immediately rinsed with plenty of water.- Operate indoors in a well-ventilated environment to avoid inhalation of aerosols.- When storing, it should be kept in a dry, ventilated, dark place, away from fire and oxidants.- Dispose of waste and containers for this chemical in accordance with relevant regulations.

Application
4-Bromo-8-hydroxyquinoline (CAS 139399-63-6) is a versatile brominated heterocyclic building block derived from the 8-hydroxyquinoline (oxine) scaffold. It serves as a key pharmaceutical intermediate in medicinal chemistry for the synthesis of bioactive molecules with broad-spectrum antimicrobial, antifungal, antiviral, and anticancer activities. The bromine at the 4-position enables cross-coupling reactions (Suzuki, Buchwald-Hartwig) for structure-activity relationship (SAR) studies, while the 8-hydroxy group acts as a potent metal chelator, allowing the compound to form stable complexes with transition metal ions (Cu²⁺, Zn²⁺, Fe³⁺). These metal complexes are investigated as therapeutic agents for neurodegenerative diseases (Alzheimer's, Parkinson's) and as fluorescent probes for bioimaging. Additionally, this scaffold is used in the synthesis of corrosion inhibitors, agrochemicals, and organic light-emitting diodes (OLEDs). Its high purity ensures reproducible results in drug discovery and materials science. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of 4-bromo-8-hydroxyquinoline with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.