5-Chloro-2-cyanopyridine（CAS# 89809-64-3)

Introduction

5-Chloro-2-cyanopyridine is an organic compound with the chemical formula C6H3ClN2. The following is a description of its nature, use, formulation and safety information:

Nature:

-Appearance: 5-Chloro-2-cyanopyridine is a colorless to pale yellow crystalline solid.

-Melting point: Its melting point is 85-87°C.

-Solubility: Good solubility in common organic solvents.

Use:

- 5-Chloro-2-cyanopyridine is often used as an intermediate compound in organic synthesis.

-It is an important raw material for the synthesis of compounds such as drugs, pesticides and dyes.

-It can also be used as a substrate for organic synthesis catalysts.

Preparation Method:

- 5-Chloro-2-cyanopyridine can be obtained by chlorinating 2-cyanopyridine.

-The reaction is usually carried out under alkaline conditions to improve the reaction efficiency.

-Generally, a reagent such as stannous chloride or antimony chloride is used as a chlorinating agent in the reaction.

Safety Information:

- 5-Chloro-2-cyanopyridine is irritating and should be rinsed with water immediately when in contact with skin or eyes.

-When operating, wear appropriate protective gloves and goggles to ensure safety.

-The compound should be kept away from fire and high temperature to prevent fire and explosion.

-It should be stored in a sealed container and away from oxidants and strong acids.

Application

5-Chloro-2-cyanopyridine (CAS 89809-64-3) is a versatile heterocyclic building block widely used in pharmaceutical and agrochemical research. As a key pharmaceutical intermediate, it serves as a crucial precursor for synthesizing proton pump inhibitors (PPIs), antibacterial agents, and anticancer drugs. The compound's reactive chlorine and cyano groups enable nucleophilic substitution and Suzuki-Miyaura cross-coupling reactions, facilitating the construction of complex molecular scaffolds for drug discovery. In agrochemical development, it is utilized to produce selective herbicides and pesticides for enhanced crop protection. It also finds applications in material science for developing advanced polymers and coatings. This high-purity compound is supplied as a light yellow crystalline solid and is available for R&D through custom synthesis and contract manufacturing. Xinchem offers reliable global supply with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote.

Please note that this is only a general introduction, specific use should also refer to the relevant chemical literature and safety data sheets.