6-Bromoquinoline-4-carboxylic acid(CAS#160233-76-1)

Introduction

6-bromoquinoline-4-carboxylic acid is an organic compound.Quality:6-Bromoquinoline-4-carboxylic acid is a white to pale yellow crystalline solid that is soluble in many organic solvents such as alcohols, ethers, and ketones. It is stable at room temperature, but decomposition can occur at high temperatures or when exposed to sunlight.Use:6-bromoquinoline-4-carboxylic acid has a wide range of uses in organic synthesis. It can also be used as a surfactant, antimicrobial agent, and coordination agent, among others.Method:There are several ways to prepare 6-bromoquinoline-4-carboxylic acid. A common method is by reacting 4-chloroquinoline with sodium bromide, followed by dehydrogenation to give 6-bromoquinoline, and finally carboxylation to give 6-bromoquinoline-4-carboxylic acid.Safety Information:6-Bromoquinoline-4-carboxylic acid is generally relatively safe under routine operating conditions, but appropriate laboratory handling and personal protective measures such as wearing gloves, goggles, and a lab coat are still required. Care should be taken to prevent contact with skin, eyes, and inhalation during handling and storage. Toxicological information for this compound is rarely reported, and appropriate risk assessment and control measures should be taken when using it.

Application
6-Bromoquinoline-4-carboxylic acid (CAS 160233-76-1) is a functionalized quinoline derivative bearing a bromine at the 6-position and a carboxylic acid at the 4-position. This versatile heterocyclic building block is widely used in medicinal chemistry and pharmaceutical research as a key intermediate for the synthesis of bioactive molecules, including potent antimalarial agents (e.g., quinoline-4-carboxamide derivatives targeting Plasmodium falciparum), antibacterial compounds, and kinase inhibitors. The bromine enables efficient cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) to introduce diverse aryl, heteroaryl, or alkyl substituents, while the carboxylic acid allows amide or ester formation for structure-activity relationship (SAR) studies. This scaffold also serves as a precursor for fluorescent probes, agrochemicals, and organic materials. Its rigid, planar quinoline core enhances target binding affinity and metabolic stability. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 6-bromoquinoline-4-carboxylic acid with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.