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CO-1686(CAS#1374640-70-6) Featured Image
  • CO-1686(CAS#1374640-70-6) 1

CO-1686(CAS#1374640-70-6)

Chemical Property:

Molecular Formula C27H28F3N7O3
Molar Mass 555.55
Density 1.372±0.06 g/cm3(Predicted)
Melting Point 202 – 205°C (dec.)
Appearance Form Solid, color Off-White
pKa 13.23±0.70(Predicted)
Storage Condition Amber Vial, -20°C Freezer, Under inert atmosphere
MDL MFCD26793864
Physical and Chemical Properties Bioactive Rociletinib (CO-1686, AVL-301) is an irreversible, selective inhibition of mutant EGFR, acting on EGFRL858R/T790M and EGFRWT in cell-free assays with Ki of 21.5 nM and 303.3 nM, respectively. Phase 2.

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Product Tags

Risk Codes R23 – Toxic by inhalation
R25 – Toxic if swallowed
R36 – Irritating to the eyes
Safety Description 24 – Avoid contact with skin.
HS Code 29335990

 

Introduction

CO-1686 (AVL-301) is an irreversible, mutation-selective EGFR inhibitor that acts on EGFRL858R/T790M and EGFRWT with a Ki of 21.5 nM and 303.3 nM, respectively. Phase 2.

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