Cyclopropaneethanamine hydrochloride（CAS# 89381-08-8)

Introduction

Cyclopropaneethanamine,hydrochloride, also known as cyclopropylethylamine hydrochloride (Cyclopropaneethanamine,hydrochloride), is an organic compound. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:

-Chemical formula: C5H9N · HCl

-Appearance: Colorless crystalline solid or powder

-Solubility: Soluble in water and ethanol, slightly soluble in chloroform

-melting point: 165-170 ℃

-boiling point: 221-224 ℃

-Density: 1.02g/cm³

Use:

- Cyclopropaneethanamine,hydrochloride are commonly used as intermediates in organic synthesis and can be used to synthesize biologically active compounds.

-It can also be used as a raw material in the pharmaceutical field, such as for the synthesis of antidepressants.

Preparation Method:

Cyclopropaneethanamine, the preparation of hydrochloride can be achieved by the following steps:

1. The cyclopropylethylamine is reacted with hydrochloric acid to obtain Cyclopropaneethanamine and hydrochloride under appropriate conditions.

2. The pure hydrochloride product is isolated from the reactant by crystallization or washing.

Safety Information:

Cyclopropaneethanamine,hydrochloride is an organic compound, and the following safety precautions need to be paid attention:

-operation should pay attention to avoid contact with skin, eyes and mucous membranes, so as not to cause irritation and damage.

-in the process of operation to do a good job of ventilation measures to avoid inhalation of its vapor.

-Follow the rules for the storage and handling of chemicals during storage and use.

Application

2-Cyclopropylethanamine hydrochloride (2-cyclopropylethylamine HCl, CAS 89381-08-8, C₅H₁₂ClN, MW 121.61 g/mol) is a high-purity primary amine building block featuring a strained cyclopropane ring. This versatile pharmaceutical intermediate is widely used as a key precursor in the synthesis of biologically active compounds and small molecule drugs. The cyclopropyl group is a privileged motif in medicinal chemistry, employed to modulate molecular properties such as metabolic stability, bioavailability, conformational rigidity, and binding affinity to biological targets. As a result, this scaffold is integral to the development of cardiovascular drugs, central nervous system (CNS) agents, anticancer therapeutics, and anti-inflammatory compounds. The primary amine functionality enables diverse derivatization via reductive amination, amidation, and nucleophilic substitution, allowing rapid expansion of chemical libraries for structure-activity relationship (SAR) studies.

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