Di-tert-butyl dicarbonate(CAS#24424-99-5)
| Hazard Symbols | T+ - Very toxicF+ - Highly flammable
Xi - Irritant |
| Risk Codes | R10 - Flammable R26 - Very Toxic by inhalation R36/37/38 - Irritating to eyes, respiratory system and skin. R43 - May cause sensitization by skin contact |
| Safety Description | S16 - Keep away from sources of ignition. S24 - Avoid contact with skin. S37/39 - Wear suitable gloves and eye/face protection S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | 2929 |
Introduction
Open Data Unverified Data
Application
Di-tert-butyl dicarbonate (CAS 24424-99-5), commonly known as Boc₂O or Boc anhydride, is the most widely used reagent for tert-butoxycarbonyl (Boc) protection of amines in organic synthesis. It is essential in peptide synthesis (solid-phase and solution-phase), pharmaceutical manufacturing, and medicinal chemistry, where selective amine protection enables stepwise construction of complex molecules. Boc₂O reacts rapidly with primary, secondary, and even sterically hindered amines under mild, neutral conditions, forming stable Boc-protected intermediates that are easily removed with mild acid (e.g., TFA). It also finds use in the protection of alcohols, thiols, and enolates. In large-scale production, Boc₂O is preferred for its high yield, crystallinity of products, and compatibility with various functional groups. Additionally, it serves in the synthesis of carbamates, ureas, and heterocycles. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity di-tert-butyl dicarbonate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
