methyl 2-aminobenzo[d]thiazole-4-carboxylate(CAS#1024054-68-9)

Introduction

methyl 2-aminobenzo[d]thiazole-4-carboxylate is an organic compound whose chemical formula is C10H8N2O2S. The following is a detailed description of its nature, use, formulation and safety information:

Nature:

-Appearance: methyl 2-aminobenzo[d]thiazole-4-carboxylate is usually a white crystalline or crystalline powdery substance.

-Solubility: It can be dissolved in most organic solvents, such as ethanol, dimethyl sulfoxide and dichloromethane.

-Melting point: Its melting point is usually between 110°C and 114°C.

Use:

- methyl 2-aminobenzo[d]thiazole-4-carboxylate is a commonly used organic synthesis intermediate and has important applications in drug synthesis. It can be used to synthesize different types of drug molecules, such as anti-epileptic drugs and antibacterial drugs.

Preparation Method:

- methyl 2-aminobenzzo [d]thiazole-4-carboxylate can be obtained by nitration and reduction of benzothiazole, and then by methanol esterification. The specific preparation method can refer to the relevant organic synthesis literature.

Safety Information:

- methyl 2-aminobenzo[d]thiazole-4-carboxylate has a certain toxicity, should comply with the corresponding safety measures.

-Avoid contact with skin and eyes during operation, and ensure that the operation is carried out under well-ventilated conditions.

-When storing and handling, it should be stored in a sealed container, away from fire and oxidizing agents.

-In the event of accidental exposure or inhalation, seek immediate medical assistance and provide the appropriate safety data sheet or instructions.

Application
Methyl 2-aminobenzo[d]thiazole-4-carboxylate (CAS 1024054-68-9) is a highly functionalized benzothiazole derivative featuring a free amino group at the 2-position and a methyl ester at the 4-position. This privileged scaffold is widely used in medicinal chemistry and drug discovery as a key intermediate for the synthesis of potent kinase inhibitors targeting cancer, inflammation, and autoimmune diseases (e.g., PI3K, CDK, and EGFR inhibitors). The amino group enables amide, urea, or sulfonamide formation, while the ester can be hydrolyzed to the carboxylic acid for further derivatization, allowing rapid structure-activity relationship (SAR) studies. Its rigid, electron-rich benzothiazole core enhances target binding affinity and metabolic stability. This building block also serves as a precursor for antiviral, antibacterial, and antifungal agents, as well as for agrochemicals and fluorescent probes. High purity ensures reproducible results in high-throughput screening and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.