2,5-dibromo-1,3-benzothiazole(CAS#1019111-64-8)

Introduction

2,5-Dibromobenzothiazole is an organic compound. The following is an introduction to its nature, use, preparation and safety information:Quality:- Appearance: 2,5-Dibromobenzothiazole is a white to light yellow crystalline solid.- Solubility: 2,5-dibromobenzothiazole is soluble in organic solvents and insoluble in water.Use:- 2,5-Dibromobenzothiazole is often used as an intermediate in organic synthesis in chemical synthesis.- It can be used as a rubber accelerator in the rubber industry.- The compound can also be used as a raw material in pesticide synthesis.Method:- The synthesis method of 2,5-dibromobenzothiazole can be obtained by the reaction of benzothiazole with bromine under appropriate conditions. For specific reaction conditions, please refer to the organic synthesis manual or literature.Safety Information:- 2,5-Dibromobenzothiazole should be handled with safety precautions, such as wearing chemical gloves, goggles and protective clothing.- It is an irritating substance that may have an irritating effect on the skin and eyes.- When used or stored, keep away from fire and high temperature conditions to prevent it from burning or exploding.

Application
2,5-Dibromo-1,3-benzothiazole (CAS 1019111-64-8) is a high-purity dihalogenated heterocyclic building block used extensively in medicinal chemistry and materials science. The two bromine atoms enable sequential orthogonal cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) to construct diverse 2,5-disubstituted benzothiazole libraries. This scaffold serves as a key pharmaceutical intermediate for the synthesis of potent kinase inhibitors targeting cancer (e.g., PI3K, CDK, EGFR), antiviral agents, and antibacterial compounds. Its rigid, electron-deficient benzothiazole core enhances metabolic stability and target binding affinity. In agrochemical research, it is utilized to develop herbicides and fungicides with improved crop protection profiles. Additionally, this intermediate supports the preparation of functional materials such as organic semiconductors, fluorescent dyes, and metal-organic frameworks (MOFs). High purity ensures reproducible results in high-throughput screening, SAR studies, and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.