5-Iodo-2-(pyridin-3-yl)thiazole(CAS#1187830-48-3)

Introduction

5-Iodo-2-(pyridin-3-yl)thiazole is an organic compound. The following is an introduction to its nature, use, preparation method and safety information:Quality:- Appearance: 5-Iodo-2-(pyridine-3-yl)thiazole is a yellow to brown solid powder.- Solubility: Soluble in some organic solvents, such as dimethyl sulfoxide, ethanol, methylene chloride, etc.Use:Method:- The preparation method of 5-iodo-2-(pyridin-3-yl)thiazole can be obtained by the reaction of pyridine acetyl sulfuric acid and 2-mercaptoacetaldehyde in the presence of cesium iodate.Safety Information:- The toxicity and danger of 5-iodo-2-(pyridin-3-yl)thiazole are not fully understood, and appropriate safety measures should be taken when using or handling this compound.- Appropriate personal protective equipment such as gloves, glasses, and lab coats need to be worn during the procedure.- The compound should be kept away from fire and high temperatures, and should be kept tightly sealed and kept in a cool, dry place when stored.

Application
This iodinated thiazole-pyridine conjugate is a key heterocyclic scaffold used as a collagen prolyl-4-hydroxylase inhibitor, with potential for studying fibrosis and tissue repair. Its derivatives demonstrate high antiproliferative activity against colon, breast, and lung cancer cell lines, while showing lower toxicity to normal cells. The iodo substituent enables efficient cross-coupling reactions (Suzuki, Sonogashira, Buchwald‑Hartwig) for rapid library expansion, and the thiazole-pyridine core exhibits metal-chelating properties for corrosion inhibition studies. It also serves as a versatile pharmacophore in drug discovery programs targeting antimicrobial and antitumor agents. Xinchem is a premier manufacturer and supplier of this compound with flexible custom synthesis and contract manufacturing capabilities. Contact us for reliable global supply and a competitive quote.