A Critical Fluorinated Building Block for Antiviral APIs, Agrochemicals & Advanced Materials: 2,4-Difluorobenzylamine (CAS# 72235-52-0)

2,4-Difluorobenzylamine (CAS# 72235-52-0), also known as (2,4-difluorophenyl)methanamine or 2,4-DFBA, is a fluorinated aromatic primary amine with the molecular formula C₇H₇F₂N and a molecular weight of 143.13 g/mol. Its molecular structure consists of a benzylamine scaffold bearing two fluorine atoms at the 2 and 4 positions of the benzene ring, combined with a reactive primary amine group (-CH₂NH₂). This specific difluorination pattern imparts unique physicochemical properties that are highly desirable in the synthesis of complex molecules. The compound typically appears as a colorless to pale yellow clear liquid with a characteristic amine odor. The carbon–fluorine bond is the strongest single bond to carbon (485 kJ/mol), and this exceptional stability underpins the “fluorine scan” strategy used in medicinal chemistry to optimize drug candidates. As a high-value fluorinated organic amine, 2,4-difluorobenzylamine serves as a critical building block for active pharmaceutical ingredients (APIs), agrochemicals, diagnostic imaging agents, and advanced materials. Its production relies on specialized fluorination chemistry, and market demand is closely tied to the global trends of innovative drug R&D, generic drug volume expansion, and green pesticide upgrading. Based on its chemical characteristics and industrial chain position, this article systematically analyzes the international market dynamics of 2,4-difluorobenzylamine, focusing on core application scenarios, competitive landscape, regional differences, regulatory trends, and future outlook, providing strategic references for industry participants.

Core Application Fields and Demand

Market demand for 2,4-difluorobenzylamine (CAS# 72235-52-0) is highly concentrated in four major areas: pharmaceutical synthesis (approximately 65–70% of global consumption), agrochemical development (approximately 15–20%), diagnostic imaging and materials science (approximately 10–15%), with the remainder in analytical chemistry and fine chemical synthesis. The unique 2,4-difluorophenyl moiety combined with the reactive amine group serves as the core advantage driving demand growth.

In pharmaceutical synthesis, 2,4-difluorobenzylamine is a cornerstone intermediate in the synthesis of several blockbuster drugs, most notably the HIV integrase inhibitor Dolutegravir (Tivicay®). The 2,4-difluorobenzyl moiety is strategically incorporated to enhance the drug’s binding affinity to the target enzyme and improve its pharmacokinetic profile. It also serves as a key intermediate for Cabotegravir, another HIV integrase inhibitor. Beyond HIV therapeutics, the compound is utilized in the synthesis of antiviral drugs including HCV NS3/4A inhibitors, anticancer agents such as kinase inhibitors and PARP inhibitors, and central nervous system (CNS) drugs. The difluorobenzylamine moiety is found in molecules such as fluvoxamine (an SSRI antidepressant), voriconazole (an antifungal), and various investigational compounds. In research settings, it is widely used in developing drugs targeting neurological disorders, where its unique fluorine substituents can enhance biological activity and selectivity.

In agrochemical development, 2,4-difluorobenzylamine serves as a crucial fluorinated building block in the design and synthesis of modern crop protection agents. It is used in the synthesis of pyrazole carboxamide fungicides, including fluopyram analogs, as well as modern fluorinated herbicides and insecticides. Fluorine substitution improves environmental stability and target selectivity, making these agrochemicals more effective and potentially more environmentally friendly.

In diagnostic imaging and materials science, the compound serves as a PET radiotracer precursor for [¹⁸F]-labeling in diagnostic imaging applications. It is also employed in the development of liquid crystal displays (LCDs), fluorinated polymers, and functional coatings requiring unique electronic or optical properties. In peptide and peptidomimetic chemistry, it serves as a precursor for fluorinated benzylamine derivatives used in peptide modification and PROTAC (proteolysis-targeting chimera) linkers.

In analytical chemistry, 2,4-difluorobenzylamine is used as a derivatizing agent, enhancing the detection and quantification of various compounds in complex mixtures.

Major Market Participants

The global supply system for 2,4-difluorobenzylamine (CAS: 72235-52-0) features a pattern of “specialized fluorinated intermediate manufacturers and regional suppliers serving distinct market segments”. The global market is estimated to be valued in the range of $3–6 million USD in 2025, with a projected CAGR of 2.2–4.2% through 2030. Industry concentration is continuously improving, with core competition focusing on high-purity pharmaceutical-grade products.

In the global high-purity pharmaceutical segment, key players include specialized fluorochemical manufacturers and fine chemical suppliers that serve the pharmaceutical and biotechnology industries. Major distributors and suppliers include Sigma-Aldrich (Merck), Chem-Impex International, TCI Chemicals, and Apollo Scientific. These companies supply research-grade and GMP-compliant material with purity ≥98% (GC). ChemContract Research supplies the compound from its California facility under cGMP conditions with full batch documentation.

In the industrial and large-scale production segment, Asian manufacturers—particularly Chinese producers—have emerged as the dominant force in global supply. China serves as the world’s primary production hub for 2,4-difluorobenzylamine, with numerous manufacturers operating production facilities and leveraging cost advantages, established supply chains, and integrated manufacturing capabilities to serve both domestic and international markets. Leading Chinese producers include specialized pharmaceutical and fine chemical companies based in provinces such as Hebei, Shaanxi, Hubei, and Zhejiang.

European and North American manufacturers focus on high-purity and specialty grades for research and high-end pharmaceutical applications, while Asian producers serve the broader industrial and intermediate markets with competitive pricing and large-scale capacity.

Regional Market Dynamics

The global 2,4-difluorobenzylamine market exhibits distinct regional characteristics, with production concentrated in Asia-Pacific and consumption distributed across North America, Europe, and emerging markets.

The Asia-Pacific region is the dominant force in the global 2,4-difluorobenzylamine market, accounting for the largest share of both production and consumption. China, in particular, serves as the world’s manufacturing hub, with extensive production capacities and integrated supply chains. The rapid growth of the pharmaceutical and agrochemical industries in China, India, and Southeast Asia continues to drive regional demand. India has emerged as an important consumer and producer, with manufacturers such as Ganesh Chem Tech serving both domestic and export markets.

North America remains a key market for high-purity and GMP-grade 2,4-difluorobenzylamine, driven by demand from the pharmaceutical and biotechnology sectors. The United States hosts major pharmaceutical companies and contract research organizations that require high-quality intermediates for drug development and manufacturing. The region relies heavily on imports for the intermediate while focusing on supply chain security and quality assurance.

Europe is characterized by stringent regulatory requirements and a strong focus on quality and sustainability. The region’s pharmaceutical industry demands GMP-compliant intermediates with full documentation. European consumption is driven by finished drug manufacturing, but the region relies heavily on imports from Asia-Pacific for the DFBA intermediate. Pharmaceutical companies in Europe seek qualified DFBA suppliers that meet cGMP and regulatory filing standards.

Latin America and other regions represent smaller but growing markets, with demand driven by expanding pharmaceutical manufacturing and agrochemical development.

Regulatory and Environmental Considerations

As a pharmaceutical intermediate and fluorinated fine chemical, 2,4-difluorobenzylamine (CAS# 72235-52-0) is subject to regulatory oversight in major global economies. Compliance with relevant regulations is essential for market access and trade.

In the United States, 2,4-difluorobenzylamine used in pharmaceutical applications must comply with relevant FDA regulations for pharmaceutical raw materials. The compound is subject to OSHA workplace safety standards and may require additional documentation for purchase. It is not DEA-regulated.

In the European Union, the compound must meet REACH regulation registration requirements. The substance has an EC number of 276-502-0 and EINECS listing. Manufacturers and suppliers must provide comprehensive safety data sheets (SDS) and comply with REACH documentation requirements.

GHS classification and handling: 2,4-Difluorobenzylamine is classified as a hazardous substance and requires careful handling to prevent exposure. It is corrosive and can cause severe skin burns and eye damage (H314). Precautionary measures include wearing protective gloves, protective clothing, eye protection, and face protection (P280). In case of eye contact, rinse cautiously with water for several minutes (P305+P351+P338). The compound should be stored locked up (P405).

For international transport, 2,4-difluorobenzylamine is classified under UN 2735 (Class 8, Packing Group III) as a corrosive liquid, basic, organic, n.o.s.. Proper packaging, labeling, and documentation are required for shipping in compliance with the International Maritime Dangerous Goods Code (IMDG Code) and other transport regulations.

Environmental considerations: The compound has a WGK Germany classification of 3 (highly hazardous to water). The Chinese export HS code is 29214990. Manufacturers are increasingly focused on developing greener production methods, including biocatalytic routes using nitrile oxidoreductase for the reduction of 2,4-difluorobenzonitrile. The product is susceptible to moisture absorption and oxidation, and pharmaceutical-grade production (typically ≥99.5%) requires anhydrous and oxygen-free conditions, closed distillation, and inert gas protection.

Future Outlook

The market outlook for 2,4-difluorobenzylamine is positive, supported by several key growth drivers across its major application segments. The global market is expected to maintain steady growth, with a projected CAGR of 2.2–4.2% through 2030.

Key growth drivers include:

1. Expansion of the HIV therapeutics market: The continued success of integrase inhibitors such as Dolutegravir and Cabotegravir, combined with expanding access to antiretroviral therapy in developing countries, sustains demand for 2,4-difluorobenzylamine as a key intermediate.
2. Growth in targeted therapeutics: The development of new antiviral, anticancer, and CNS drugs incorporating fluorinated pharmacophores continues to drive demand for fluorinated building blocks.
3. Increasing demand for modern agrochemicals: The global trend toward more effective and environmentally friendly crop protection agents supports demand for fluorinated intermediates in pesticide synthesis.
4. Expansion of diagnostic imaging: The growing use of PET imaging in oncology and neurology drives demand for [¹⁸F]-labeled tracer precursors.
5. Innovation in materials science: The development of fluorinated polymers, liquid crystal displays, and functional coatings creates new application opportunities.

Challenges and considerations:

• Regulatory scrutiny: Increasingly stringent pharmaceutical and environmental regulations may require ongoing investment in quality systems and compliance.
• Raw material price volatility: Fluctuations in the prices of fluorination reagents and starting materials may impact production costs.
• Technical barriers: The stringent requirements for pharmaceutical-grade purity (typically ≥99.5%) and the need for anhydrous, oxygen-free production conditions create significant barriers to entry.
• Competition from alternatives: The market faces competition from other fluorinated intermediates and synthetic routes.

To succeed in this evolving market landscape, suppliers must focus on product quality, supply chain reliability, regulatory compliance, and the development of sustainable production methods. Companies that can offer high-purity products, flexible packaging options, and responsive technical support will be well-positioned to capture growing demand.

Shanghai XinChem Co., Ltd. (XinChem)

As a world-leading supplier of organic chemicals, Shanghai XinChem Co., Ltd. (XinChem) is dedicated to meeting the innovative needs of the pharmaceutical, agrochemical, and specialty chemical industries. Leveraging extensive experience and advanced manufacturing capabilities, XinChem provides high-quality 2,4-Difluorobenzylamine (CAS# 72235-52-0) to customers worldwide. As a trusted manufacturer and supplier based in China, XinChem combines competitive pricing, reliable supply, and exceptional service to establish itself as a preferred partner for businesses seeking this versatile fluorinated intermediate.

1. Technical Advantages

Advanced Fluorination and Purification Processes
XinChem utilizes state-of-the-art manufacturing facilities and rigorous quality control measures to ensure the purity, consistency, and safety of its 2,4-difluorobenzylamine products. The production process incorporates advanced catalytic hydrogenation reduction and continuous ammonolysis processes, which offer advantages of high yield, reduced waste, and controllable cost. Strict process control minimizes impurities—particularly moisture, free fluorine, and color index—and ensures batch-to-batch consistency. The entire production process is carried out under anhydrous and oxygen-free conditions with closed distillation and inert gas protection.

Full-Chain Quality Control
The production process strictly adheres to international quality standards, with ISO9001-certified quality and GMP-aligned manufacturing. Comprehensive quality control covers raw material sourcing, in-process monitoring, and finished product testing. Each batch is accompanied by a detailed Certificate of Analysis (COA) documenting physical and chemical properties, purity data, and impurity profiles. This commitment to quality ensures that XinChem’s 2,4-difluorobenzylamine meets the stringent requirements of pharmaceutical, agrochemical, and industrial applications.

2. Product Advantages

High Purity and Consistent Quality
XinChem offers 2,4-difluorobenzylamine in multiple purity grades: Pharmaceutical grade with purity ≥99.0% (GC) and Technical grade with purity ≥98.0% (GC). The product’s high purity minimizes the risk of unwanted side reactions and impurities, making it suitable for demanding applications in pharmaceuticals and agrochemicals.

Comprehensive Specifications
Key specifications include:

• Appearance: Colorless to pale yellow clear liquid
• Density (25°C): ~1.180 g/cm³
• Boiling Point: 70–72°C (at 10 mmHg)
• Flash Point: 75°C (closed cup)
• Refractive Index (nD20): 1.492
• Water Content (KF): ≤0.3%
• Color (APHA): ≤50
• Single Maximum Impurity: ≤0.5%
• Total Impurities: ≤1.0%
• Shelf Life: 12 months under recommended storage conditions

Flexible Packaging Solutions
XinChem provides a range of packaging options to accommodate diverse customer needs, from laboratory-scale quantities to industrial-scale drums and bulk shipments. Customized packaging solutions are available upon request, ensuring safe handling, storage, and transportation.

3. Application Fields

As a versatile fluorinated building block, 2,4-Difluorobenzylamine (CAS# 72235-52-0) exhibits wide application value across multiple industries:

Pharmaceutical Industry (API Synthesis):

• Key building block for antiviral drugs, including HIV integrase inhibitors such as Dolutegravir and Cabotegravir
• Intermediate for HCV NS3/4A inhibitors and anticancer agents (kinase inhibitors, PARP inhibitors)
• Precursor for CNS drugs, including antidepressants and antifungals
• Building block for peptide modification and PROTAC linkers

Agrochemicals:

• Synthesis of modern fluorinated pesticides, including fungicides (fluopyram analogs), herbicides, and insecticides
• Fluorine substitution improves environmental stability and target selectivity

Diagnostic Imaging:

• PET radiotracer precursor for [¹⁸F]-labeling in diagnostic imaging applications

Materials Science:

• Production of fluorinated polymers, liquid crystal displays (LCDs), and functional coatings

Fine Chemical Synthesis:

• Intermediate for manufacturing specialty amines, amides, Schiff bases, and heterocyclic compounds (e.g., benzimidazoles, quinazolines)

4. Service Support

Technical Expertise and Customized Solutions
XinChem’s team of experienced chemists and application engineers provides full technical support throughout the customer journey—from product selection and specification development to application guidance and troubleshooting. Whether customers require optimization of synthesis parameters, guidance on handling and storage, or assistance with regulatory documentation, XinChem’s technical experts are ready to help.

Global Logistics and Reliable Supply
With established supply chains serving markets across Europe, North America, Asia-Pacific, and beyond, XinChem ensures timely delivery and consistent product availability. The company’s logistics team manages all aspects of international shipping, including compliance with dangerous goods transport regulations (UN 2735, Class 8), customs clearance, and documentation.

Regulatory Support
XinChem provides comprehensive documentation to support regulatory compliance, including Safety Data Sheets (SDS), Certificates of Analysis (COA), and other required certificates. The company stays current with evolving regulatory requirements in major markets, including REACH, FDA, and other regional regulations, helping customers navigate the complexities of global trade.

5. Reasons to Choose XinChem

• Professionalism: Extensive experience and deep expertise in fluorination chemistry and fine chemical synthesis.
• Quality: Rigorous quality control, ISO9001-certified quality, and GMP-aligned manufacturing.
• Reliability: Stable supply, competitive pricing, and timely delivery.
• Flexibility: Customized solutions to meet diverse customer needs, including custom synthesis of fluorinated amines and derivatives.
• Service: Responsive technical support and comprehensive documentation.

Contact us today to start your partnership with XinChem!

Website: www.xinchem.com

Email: sales1@xinchem.com

WhatsApp: +86 18049800532