1-Hexen-3-one (CAS# 1629-60-3), also known as propyl vinyl ketone, vinyl propyl ketone, or hex-1-en-3-one, is a volatile α,β-unsaturated ketone (enone) with the molecular formula C₆H₁₀O and a molecular weight of 98.14 g/mol. Its molecular structure features a six-carbon chain with a terminal double bond and a ketone functional group at the third position, creating a conjugated vinyl ketone system that confers both high olfactory potency and electrophilic reactivity. As a colorless to pale yellow liquid with a pungent, metallic, green, and cooked vegetable-like odor, 1-hexen-3-one is a naturally occurring flavor compound found in a variety of foods and botanicals—including papaya, artichokes, butter, corn oil, raspberries, rosemary essential oil, and cured hams. The compound’s unique sensory profile and reactive chemical structure make it a valuable ingredient in the flavor industry, a useful building block for organic synthesis, and a subject of increasing interest in pharmaceutical and agrochemical research. This article systematically analyzes the key properties, core application areas, global market structure, regulatory landscape, and future outlook of 1-hexen-3-one, providing strategic reference for industry participants.
Core Application Fields and Demand
Market demand for 1-hexen-3-one (CAS# 1629-60-3) is concentrated in three primary areas: the flavor industry, organic synthesis and pharmaceutical intermediates, and agrochemical and specialty chemical applications.
In the flavor industry, 1-hexen-3-one is valued for its distinctive organoleptic properties. Its flavor profile is described as ethereal, whiskey-like, metallic, fruity, and tropical at low concentrations (approximately 20 ppm). The compound occurs naturally in artichokes, butter, and corn oil, and is used for vegetable flavoring in food and beverages. It is listed as an EU-recognized flavoring substance (FL No. 07.161) and is typically used in various food categories at average usage levels ranging from 1.0 to 5.0 mg/kg. The compound’s ability to impart cooked vegetable, metallic, and green notes makes it an important component in savory flavor formulations, including those for soups, sauces, snacks, and meat-flavored products. Importantly, the compound is not recommended for fragrance use, as its odor characteristics are considered more suitable for flavor applications.
In organic synthesis and pharmaceutical research, 1-hexen-3-one serves as a versatile and reactive building block. As an α,β-unsaturated ketone, it is an excellent Michael acceptor, readily undergoing conjugate addition reactions with various nucleophiles. It can be used in the synthesis of 2-pyridones from α,β-unsaturated ketones and serves as a valuable intermediate for the synthesis of compounds with potential applications in the pharmaceutical and agrochemical industries. The compound’s conjugated system makes it a subject of interest in organic synthesis and as a volatile signaling molecule in biological systems. Additionally, 1-hexen-3-one has been shown to act as an estrogen receptor modulator, suggesting potential biological activity worthy of further investigation.
In agrochemical and specialty chemical applications, 1-hexen-3-one is recognized as an important organic intermediate that can be used in the agrochemical and dyestuff fields. Vinyl ketones, including propyl vinyl ketone, are used in photosensitive compositions, photodegradable polymer masterbatches, pigment dispersion liquids, and curable compositions.
Key Market Participants
The global supply system for 1-hexen-3-one (CAS# 1629-60-3) features a pattern of “specialty chemical manufacturers, research-grade suppliers, and regional producers serving distinct market segments.”
In the global research and high-purity segment, major suppliers include Thermo Scientific (Alfa Aesar), which offers 1-hexen-3-one at ≥90% purity stabilized with 0.5% 4-methoxyphenol. Other international distributors and suppliers include Fisher Scientific, VWR, AKSci, and BenchChem. These companies serve the research, pharmaceutical development, and analytical laboratory markets with products that meet rigorous quality specifications.
In the industrial and large-scale production segment, Chinese manufacturers have emerged as important players in the global supply chain. Numerous Chinese chemical companies operate production facilities for 1-hexen-3-one, leveraging cost advantages and established supply chains to serve both domestic and international markets. Tianjin Yuansu Chemical Reagent Co., LTD is one such supplier offering 1-hexen-3-one under the category of organic chemicals and derivatives/aroma compounds. Nanjing Raymon Biotech Co., Ltd. and Henan Kanbei Chemical Co., LTD are also active in the production and supply of this compound.
Penta Manufacturing Company, based in North America, is another established producer serving the flavor and fragrance industries.
Regional Market Dynamics
The global 1-hexen-3-one market exhibits distinct regional characteristics, with production distributed across Asia-Pacific, North America, and Europe, and consumption aligned with the flavor, pharmaceutical, and chemical industries in these regions.
The Asia-Pacific region has emerged as a significant production hub for 1-hexen-3-one, with China hosting numerous manufacturers and suppliers. The region’s competitive advantages include lower production costs, established chemical infrastructure, and proximity to rapidly growing end-use industries. Chinese suppliers offer the compound at various purity grades and packaging options, serving both domestic and export markets.
North America remains a key market for high-purity and research-grade 1-hexen-3-one, driven by demand from the flavor, pharmaceutical, and specialty chemical industries. The United States hosts major suppliers such as Thermo Scientific (Alfa Aesar) and Penta Manufacturing Company, which serve the research, development, and industrial markets with products meeting stringent quality specifications. The region’s well-established regulatory framework and emphasis on product quality support demand for high-grade intermediates and flavoring substances.
Europe is characterized by stringent regulatory requirements and a strong focus on quality and safety in food and pharmaceutical applications. The compound is listed as an EU-recognized flavoring substance (FL No. 07.161), and its use in food applications is regulated under EU flavoring regulations. European manufacturers and distributors supply research-grade and food-grade material to the region’s flavor, pharmaceutical, and chemical industries.
Regulatory and Safety Considerations
As a flavoring substance, research chemical, and industrial intermediate, 1-hexen-3-one (CAS# 1629-60-3) is subject to regulatory oversight in major global economies. Compliance with relevant regulations is essential for market access and trade.
In the European Union, 1-hexen-3-one is listed as an EU-recognized flavoring substance with FL No. 07.161. The compound has an EINECS number of 216-625-9 and is REACH pre-registered. Manufacturers and suppliers must provide comprehensive safety data sheets (SDS) and comply with REACH documentation requirements.
In the United States, 1-hexen-3-one has an FDA Unique Ingredient Identifier (UNII) of QH9D98Z86N and is listed in the FDA Substance Registration System. The compound is subject to FDA oversight for food flavoring applications and must comply with relevant regulations for synthetic flavoring substances and adjuvants.
GHS classification and handling: 1-Hexen-3-one is classified as a highly flammable liquid and vapor (H225). It causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Precautionary measures include keeping away from heat, sparks, open flames, and hot surfaces (P210), avoiding breathing dust/fume/gas/mist/vapors/spray (P261), and storing locked up (P405). In case of skin contact, remove contaminated clothing and rinse skin with water/shower (P303+P361+P353); in case of eye contact, rinse cautiously with water for several minutes and remove contact lenses if present (P305+P351+P338).
For international transport, 1-hexen-3-one is classified under UN 1224 (Ketones, liquid, n.o.s., Class 3, Packing Group II). Proper packaging, labeling, and documentation are required for shipping in compliance with the International Maritime Dangerous Goods Code (IMDG Code) and other transport regulations.
Storage and stability: 1-Hexen-3-one should be stored at 4°C, protected from heat, and kept away from oxidizing agents and light. The compound is typically supplied at ≥90% purity stabilized with 0.5% 4-methoxyphenol to prevent polymerization. Laboratory procurement typically supplies the compound at ≥90% purity.
Future Outlook
The market outlook for 1-hexen-3-one is positive, supported by several key growth drivers across its major application segments. While the compound remains a relatively niche specialty chemical, its unique properties and versatility position it for steady growth in the coming years.
Key growth drivers include:
- Expansion of the savory flavor market: The growing global demand for natural and natural-identical savory flavors, driven by the increasing popularity of processed foods, snacks, and convenience meals, supports demand for distinctive flavoring compounds like 1-hexen-3-one.
- Growth in pharmaceutical R&D: The compound’s role as a reactive building block and Michael acceptor in organic synthesis makes it valuable for drug discovery and development, particularly in the synthesis of novel bioactive molecules.
- Increasing interest in natural-identical flavorings: As consumers seek more authentic and natural-tasting food products, the use of naturally occurring flavor compounds—including those found in papaya, artichokes, butter, and corn oil—continues to grow.
- Expansion of agrochemical research: The compound’s applications in agrochemical synthesis and as an intermediate for crop protection agents support steady demand from the agricultural chemical sector.
- Innovation in specialty chemicals: The use of vinyl ketones, including propyl vinyl ketone, in photosensitive compositions, photodegradable polymers, and curable materials opens new application opportunities in advanced materials.
Challenges and considerations:
- Regulatory compliance: Increasingly stringent food safety and chemical regulations may require ongoing investment in quality systems and documentation.
- Stability and handling: The compound’s flammability, reactivity, and need for stabilization with 4-methoxyphenol require careful handling and storage, potentially limiting its use in some applications.
- Competition from alternatives: The market faces competition from other flavoring compounds and synthetic intermediates that may offer similar properties at lower cost.
- Limited scale: As a relatively niche compound, the market for 1-hexen-3-one is smaller than that of commodity chemicals, which may limit investment in large-scale production capacity.
To succeed in this evolving market landscape, suppliers must focus on product quality, supply chain reliability, regulatory compliance, and responsive customer service. Companies that can offer high-purity products, flexible packaging options, and technical support will be well-positioned to capture growing demand.
Shanghai XinChem Co., Ltd. (XinChem)
As a world-leading supplier of organic chemicals, Shanghai XinChem Co., Ltd. (XinChem) is dedicated to meeting the innovative needs of the flavor, pharmaceutical, agrochemical, and specialty chemical industries. Leveraging extensive experience and advanced manufacturing capabilities, XinChem provides high-quality 1-Hexen-3-one (CAS# 1629-60-3) to customers worldwide. As a trusted manufacturer and supplier based in China, XinChem combines competitive pricing, reliable supply, and exceptional service to establish itself as a preferred partner for businesses seeking this versatile α,β-unsaturated ketone.
1. Technical Advantages
Advanced Synthesis and Purification Processes
XinChem utilizes state-of-the-art manufacturing facilities and rigorous quality control measures to ensure the purity, consistency, and safety of its 1-hexen-3-one products. The production process incorporates advanced synthesis and purification technologies, enabling the delivery of products with purity ≥90% (stabilized with 0.5% 4-methoxyphenol) to meet diverse application requirements. Strict process control minimizes impurities and ensures batch-to-batch consistency, providing customers with reliable performance in their formulations.
Full-Chain Quality Control
The production process strictly adheres to international quality standards, with comprehensive quality control covering raw material sourcing, in-process monitoring, and finished product testing. Each batch is accompanied by a detailed Certificate of Analysis (COA) documenting physical and chemical properties, purity data, and impurity profiles. This commitment to quality ensures that XinChem’s 1-hexen-3-one meets the stringent requirements of flavor, pharmaceutical, and industrial applications.
2. Product Advantages
High Purity and Consistent Quality
XinChem offers 1-hexen-3-one with purity ≥90%, stabilized with 0.5% 4-methoxyphenol to prevent polymerization. The product’s high purity and stability minimize the risk of unwanted side reactions and degradation, making it suitable for demanding applications in flavor formulation, organic synthesis, and pharmaceutical research.
Comprehensive Specifications
Key specifications include:
- Appearance: Colorless to pale yellow liquid
- Density: 0.840 g/mL
- Boiling Point: 127–129°C
- Flash Point: 22°C (71°F)
- Refractive Index: 1.4275
- Molecular Formula: C₆H₁₀O
- Molecular Weight: 98.14 g/mol
- Solubility: Slightly soluble in water; soluble in alcohol
Flexible Packaging Solutions
XinChem provides a range of packaging options to accommodate diverse customer needs, from laboratory-scale quantities to industrial-scale drums and bulk shipments. Customized packaging solutions are available upon request, ensuring safe handling, storage, and transportation. Recommended storage conditions include refrigeration at 4°C, protection from heat and light, and isolation from oxidizing agents.
3. Application Fields
As a versatile α,β-unsaturated ketone, 1-Hexen-3-one (CAS# 1629-60-3) exhibits wide application value across multiple industries:
Flavor Industry:
- Savory flavoring agent for vegetable, meat, and snack applications
- Natural-identical flavor compound for soups, sauces, and processed foods
- Provides cooked vegetable, metallic, and green notes at low concentrations (1.0–5.0 mg/kg)
- EU-recognized flavoring substance (FL No. 07.161)
Organic Synthesis and Pharmaceutical Research:
- Michael acceptor for conjugate addition reactions with various nucleophiles
- Building block for the synthesis of 2-pyridones and other heterocyclic compounds
- Intermediate for pharmaceutical and agrochemical compound synthesis
- Subject of interest as a volatile signaling molecule in biological systems
Agrochemicals:
- Intermediate for the synthesis of crop protection agents
Specialty Chemicals:
- Component in photosensitive compositions and photodegradable polymers
- Intermediate for dyestuff and pigment applications
4. Service Support
Technical Expertise and Customized Solutions
XinChem’s team of experienced chemists and application engineers provides full technical support throughout the customer journey—from product selection and specification development to application guidance and troubleshooting. Whether customers require optimization of synthesis parameters, guidance on handling and storage, or assistance with regulatory documentation, XinChem’s technical experts are ready to help.
Global Logistics and Reliable Supply
With established supply chains serving markets across Europe, North America, Asia-Pacific, and beyond, XinChem ensures timely delivery and consistent product availability. The company’s logistics team manages all aspects of international shipping, including compliance with dangerous goods transport regulations (UN 1224, Class 3, Packing Group II), customs clearance, and documentation.
Regulatory Support
XinChem provides comprehensive documentation to support regulatory compliance, including Safety Data Sheets (SDS), Certificates of Analysis (COA), and other required certificates. The company stays current with evolving regulatory requirements in major markets, including REACH, FDA, and other regional regulations, helping customers navigate the complexities of global trade.
5. Reasons to Choose XinChem
- Professionalism: Extensive experience and deep expertise in specialty chemical synthesis and supply.
- Quality: Rigorous quality control and adherence to international standards.
- Reliability: Stable supply, competitive pricing, and timely delivery.
- Flexibility: Customized solutions to meet diverse customer needs.
- Service: Responsive technical support and comprehensive documentation.
Contact us today to start your partnership with XinChem!
Website: www.xinchem.com
Email: sales1@xinchem.com
WhatsApp: +86 18049800532
Post time: Aug-21-2026