2,2-Dimethyl-5-vinyl-1,3-dioxan-5-ol (also known as 5-ethenyl-2,2-dimethyl-1,3-dioxan-5-ol, CAS: 933791-84-5) is a bifunctional 1,3-dioxane derivative bearing a tertiary alcohol at the C5 position and a pendant vinyl group. With the molecular formula C₈H₁₄O₃ and a molecular weight of 158.19 g/mol, it typically appears as a colorless liquid. The compound features a 1,3-dioxane ring with two methyl groups at the 2-position, a tertiary hydroxyl group at the 5-position, and a vinyl substituent at the same carbon. Key physical properties include a density of approximately 1.0 g/cm³ and a predicted boiling point of around 225-230°C. The acetal functionality is acid-labile, providing a versatile protecting group strategy, while the vinyl group enables further functionalization through cross-coupling, polymerization, or oxidation reactions.
As a specialized bifunctional building block, 2,2-dimethyl-5-vinyl-1,3-dioxan-5-ol serves as a valuable intermediate in organic synthesis, particularly for the preparation of pharmaceutical active ingredients. The compound’s unique combination of a protected diol (acetal) and an alkene functionality provides orthogonal reactivity that can be selectively manipulated under mild conditions. Its production typically involves the Grignard addition of vinylmagnesium bromide to 2,2-dimethyl-1,3-dioxan-5-one. Market demand is closely linked to the global pharmaceutical and agrochemical industries, driven by the increasing need for versatile building blocks in drug discovery and development. Based on its chemical characteristics and industrial chain position, this article systematically analyzes international market dynamics of 2,2-dimethyl-5-vinyl-1,3-dioxan-5-ol, focusing on core application scenarios, competitive landscape, regional differences, regulatory trends, and future outlook, providing strategic references for industry participants.
Core Application Fields and Demand
Market demand for 2,2-dimethyl-5-vinyl-1,3-dioxan-5-ol is concentrated in three major sectors: pharmaceutical synthesis and drug discovery (≈50-55% of global consumption), agrochemical production (≈20-25%), and advanced organic synthesis and specialty chemicals (≈15-20%), with additional demand from academic research and material science applications (≈5-10%).
In the pharmaceutical synthesis and drug discovery sector, 2,2-dimethyl-5-vinyl-1,3-dioxan-5-ol serves as a key intermediate for the synthesis of antiviral agents, particularly in the preparation of famciclovir, a nucleoside analogue used for the treatment of herpes zoster and herpes simplex infections. The compound has been specifically employed as an intermediate in a synthetic route to famciclovir: alkylation of 2,2-dimethyl-1,3-dioxan-5-one with vinylmagnesium bromide yields the 2,2-dimethyl-5-vinyl-1,3-dioxan-5-ol derivative, which is subsequently converted to the mixed carbonate. The compound is also used in the preparation of 9-[2-(2,2-dimethyl-1,3-dioxan-5-yl)ethyl]-9H-purin-2-amine and other purine derivatives, expanding its utility in nucleoside analogue chemistry. The tertiary alcohol and vinyl group provide handles for further derivatization, enabling medicinal chemists to explore structure-activity relationships (SAR) and optimize drug candidates. The global pharmaceutical intermediates market continues to sustain demand for specialized building blocks.
In the agrochemical production sector, 2,2-dimethyl-5-vinyl-1,3-dioxan-5-ol is utilized as a building block for the synthesis of herbicides, fungicides, and other crop protection agents. The acetal and vinyl functionalities enable the construction of complex molecular architectures with tailored biological activity. The growing global population and the resulting need to increase agricultural productivity continue to drive demand for high-performance agrochemical intermediates.
In advanced organic synthesis and specialty chemicals, 2,2-dimethyl-5-vinyl-1,3-dioxan-5-ol serves as a versatile building block for constructing complex molecular architectures. The acetal protecting group can be selectively removed under acidic conditions to reveal a 1,3-diol, while the vinyl group can participate in cross-coupling, polymerization, or oxidation reactions. The compound’s orthogonal reactivity makes it valuable for synthesizing libraries of functionalized molecules for high-throughput screening and for producing specialty chemicals with tailored properties. It is also used in the preparation of macrocycles and other advanced intermediates for natural product synthesis.
Major Market Participants
The global supply system for 2,2-dimethyl-5-vinyl-1,3-dioxan-5-ol follows a pattern of specialized fine chemical and pharmaceutical intermediate manufacturers, with production concentrated in China, Europe, and North America. The compound is generally supplied as a colorless liquid with purity ranging from 95% to ≥98% (verified by GC or HPLC analysis), often with TBC (tert-butylcatechol) as a stabilizer to prevent polymerization. Major international suppliers include BenchChem (offering research quantities with documentation), AK Scientific (offering 95% purity with MDL MFCD12922679), CymitQuimica (offering 95% purity), MolCore (offering ≥98% purity with ISO certification), and Alchem Pharmtech (offering 95% purity). Chinese manufacturers dominate global supply, with key producers offering competitive pricing at scales ranging from research quantities to industrial batches.
Shanghai XinChem Co., Ltd. (XinChem) has established a reliable, quality-controlled supply chain for high-purity 2,2-Dimethyl-5-vinyl-1,3-dioxan-5-ol (CAS 933791-84-5). Our product is manufactured under strict quality management, achieving consistent purity (≥95-98%) with low impurity profiles, fully complying with global pharmaceutical and research standards. It is available in research grade (for laboratory and R&D applications), industrial grade (for agrochemical and material synthesis), and high-purity grade (for pharmaceutical and advanced applications).
Regional Market Dynamics
Global demand for 2,2-dimethyl-5-vinyl-1,3-dioxan-5-ol shows regional differentiation: “Asia-Pacific dominates production, North America and Europe lead in high-purity pharmaceutical and research applications, and Latin America and Middle East & Africa are emerging growth regions.”
Asia-Pacific, particularly China, is the world’s largest producer and fastest-growing region for acetal intermediates. Chinese manufacturers, including XinChem, offer competitive pricing at scales ranging from research quantities to industrial batches, serving both domestic demand for pharmaceutical and agrochemical intermediates and exports to global markets. The region’s expanding pharmaceutical manufacturing base, coupled with growing investment in agrochemical research and development, continues to drive demand for high-purity acetal building blocks.
North America (United States and Canada) and Europe (Germany, Switzerland, United Kingdom, France) together account for the largest share of high-purity pharmaceutical and research consumption (≥99%), driven by the highest concentration of pharmaceutical R&D, agrochemical innovation, and academic research. Customer requirements in these regions are stringent: purity ≥98%, full traceability, compliance with REACH and TSCA regulations, and comprehensive impurity documentation.
Japan and South Korea demand ultra-high-purity grades for advanced pharmaceutical development and high-performance material applications.
Regulatory and Environmental Considerations
2,2-Dimethyl-5-vinyl-1,3-dioxan-5-ol (CAS 933791-84-5) is subject to regulatory oversight in major economies, particularly when intended for pharmaceutical, agrochemical, and research applications. The compound has an MDL number of MFCD12922679. The compound is typically supplied with TBC (tert-butylcatechol) as a stabilizer to inhibit unwanted polymerization.
Recommended storage conditions: store in a tightly sealed container at 2-8°C or at room temperature in a cool, dark place, protected from light, moisture, and air. The vinyl group may polymerize over time, so the presence of a stabilizer (TBC) is recommended. Personal protective equipment (PPE) — including chemical-resistant gloves, safety glasses, and respiratory protection — is recommended during handling. The compound should be kept away from strong oxidizing agents, strong acids, and strong bases. Standard laboratory safety practices should be followed.
In the European Union, 2,2-dimethyl-5-vinyl-1,3-dioxan-5-ol is subject to REACH regulations; importers and manufacturers must provide Safety Data Sheets (SDS). In the United States, the compound is regulated under TSCA; for pharmaceutical API use, adherence to cGMP guidelines (21 CFR Parts 210/211) is required. In China, the compound is listed in the Inventory of Existing Chemical Substances (IECSC) and requires safety production licenses for manufacturing facilities.
Environmentally, the compound is expected to be moderately biodegradable. Manufacturing processes generate solvent-containing waste streams requiring proper treatment and disposal in accordance with environmental regulations.
Future Outlook
The market outlook for 2,2-dimethyl-5-vinyl-1,3-dioxan-5-ol is tied to three core drivers: (1) sustained growth in global demand for antiviral pharmaceutical intermediates, particularly nucleoside analogues and famciclovir-related APIs; (2) rising demand for high-performance agrochemicals to ensure food security, where acetal building blocks serve as key intermediates for next-generation crop protection agents; and (3) expanding applications in advanced organic synthesis, where the compound’s orthogonal reactivity (acetal protection + vinyl functionalization) provides unique value for constructing complex molecular architectures. The compound’s role as a key intermediate in famciclovir synthesis positions it for steady demand as generic and branded antiviral drug production continues to expand. Challenges include: raw material cost volatility for Grignard reagents and acetal precursors, competition from alternative synthetic routes to famciclovir and related antiviral agents, and the need for continued investment in high-purity production and quality control. Enterprises should focus on securing high-purity (≥98%) production capabilities, maintaining rigorous impurity documentation for global regulatory filings, ensuring compliance with REACH and TSCA requirements, and building long-term supply partnerships with pharmaceutical manufacturers, agrochemical companies, and research institutions.
Shanghai XinChem Co., Ltd. (XinChem)
As a world-leading supplier of acetal intermediates, pharmaceutical building blocks, and specialty chemicals, Shanghai XinChem Co., Ltd. (XinChem) has always focused on the innovative needs of the pharmaceutical, agrochemical, and chemical research industries. Relying on core advantages in organic synthesis, acetal chemistry, quality control, and global logistics, we provide high-quality 2,2-Dimethyl-5-vinyl-1,3-dioxan-5-ol (CAS 933791-84-5) to global customers. Our product is manufactured under strict quality management, achieving consistent specifications for pharmaceutical, agrochemical, and research grades. Fully compliant with international quality standards, it is an ideal bifunctional acetal building block for pharmaceutical API synthesis, agrochemical development, and advanced organic chemistry.
1. Technical Advantages
High Purity & Consistency: Our 2,2-dimethyl-5-vinyl-1,3-dioxan-5-ol achieves purity levels of ≥95-98% (verified by GC/HPLC analysis), supplied as a colorless liquid, molecular weight 158.19 g/mol, molecular formula C₈H₁₄O₃, MDL MFCD12922679.
Low Impurity Profile: Strict control of residual solvents, heavy metals, and related substances ensures high performance for pharmaceutical, agrochemical, and research applications.
Multiple Grades Available: We offer research grade (for laboratory and R&D applications), industrial grade (for agrochemical and material synthesis), and high-purity grade (for pharmaceutical and advanced applications). Stabilized grades with TBC are available upon request.
Batch-to-Batch Uniformity: Rigorous analytical testing (GC, HPLC, NMR, density, refractive index) guarantees consistent quality and reproducible performance across all production lots.
2. Product Advantages
Versatile Bifunctional Acetal Building Block: Directly used in pharmaceutical synthesis (famciclovir API, nucleoside analogues, purine derivatives, antiviral agents), agrochemical production (herbicides, fungicides), and advanced organic synthesis (macrocycles, natural product intermediates).
Orthogonal Reactivity: The acetal protecting group can be selectively removed under acidic conditions to reveal a 1,3-diol, while the vinyl group enables cross-coupling, polymerization, or oxidation reactions, providing versatile functionalization options.
Proven Pharmaceutical Utility: Key intermediate in the synthetic route to famciclovir, a clinically important antiviral drug.
Flexible Packaging: 1g, 5g, 10g, 25g, 100g, 500g (R&D); 1kg, 5kg, 10kg, 25kg HDPE drums/steel drums (industrial); full custom packaging available.
Reliable Supply Chain: Annual capacity in the multi-ton range, with dedicated temperature-controlled warehousing (2-8°C or cool, dark, sealed containers) and just-in-time delivery capabilities.
3. Application Fields
- Pharmaceutical Synthesis: Famciclovir API (antiviral), nucleoside analogues, purine derivatives, 9-[2-(2,2-dimethyl-1,3-dioxan-5-yl)ethyl]-9H-purin-2-amine, and other antiviral drug candidates.
- Agrochemical Production: Herbicides, fungicides, and crop protection agents.
- Advanced Organic Synthesis: Macrocycles, natural product intermediates, functionalized molecules for high-throughput screening, and specialty chemicals.
- Material Science: Polymer precursors, functional materials, and coating components.
- Academic Research: Methodology development, reaction optimization, and chemical biology studies.
4. Service Support
Our technical team provides synthetic application guidance, impurity profiling, custom packaging, and regulatory documentation (Certificate of Analysis, Technical Data Sheet, Safety Data Sheet, REACH compliance, TSCA certification). We offer just-in-time delivery and custom synthesis of acetal derivatives upon request.
5. Why Choose XinChem
- Professionalism: 20+ years in the pharmaceutical, agrochemical, and specialty chemical industries.
- Flexibility: Tailored to customer purity specifications, grade requirements, packaging sizes, and regulatory documentation needs.
- Cost-effectiveness: High quality at competitive industrial pricing.
Contact us now to start cooperation!
Website: www.xinchem.com
Email: sales1@xinchem.com
WhatsApp: +86 18049800532
Post time: Aug-02-2026