Methyl 3-Amino-4,4,4-Trifluorocrotonate (CAS: 107638-19-7) is a fluorinated β-enamino ester with the molecular formula C₅H₆F₃NO₂ and a molecular weight of 169.1 g/mol. It appears as a white to off-white crystalline solid with a melting point of 50-52°C, a boiling point of approximately 208.3°C, and a density of approximately 1.320 g/cm³. The compound combines the structural features of a β-amino-α,β-unsaturated ester with the unique properties imparted by a trifluoromethyl (-CF₃) group.
As a versatile fluorinated building block, Methyl 3-Amino-4,4,4-Trifluorocrotonate is widely used in the synthesis of pharmaceutical intermediates, agrochemicals, and specialty materials. The presence of the trifluoromethyl group enhances lipophilicity, metabolic stability, and binding affinity in drug molecules, while the β-enamino ester functionality enables diverse chemical transformations including substitution, oxidation, reduction, and condensation reactions. Market demand is closely linked to the global expansion of fluorinated pharmaceuticals, the increasing need for high-performance agrochemicals, and the growing interest in fluorinated polymers for advanced material applications. Based on its chemical characteristics and industrial chain position, this article systematically analyzes international market dynamics of Methyl 3-Amino-4,4,4-Trifluorocrotonate, focusing on core application scenarios, competitive landscape, regional differences, regulatory trends, and future outlook, providing strategic references for industry participants.
Core Application Fields and Demand
Market demand for Methyl 3-Amino-4,4,4-Trifluorocrotonate is concentrated in three major sectors: pharmaceutical synthesis (≈50-60% of global consumption), agrochemical intermediate production (≈25-30%), and material science & fluorine chemistry research (≈10-15%).
In the pharmaceutical sector, Methyl 3-Amino-4,4,4-Trifluorocrotonate is particularly important in the synthesis of fluorinated amino acids and pharmaceuticals. The trifluoromethyl moiety contributes to enhanced biological activity and selectivity in drug design. The compound has been investigated for its potential in developing drugs targeting neurological disorders due to its ability to modify neurotransmitter pathways effectively. Research indicates that derivatives of this compound may exhibit antiviral properties, making it a candidate for further drug development. The compound also serves as a key starting point for cyclization reactions to synthesize trifluoromethyl-substituted heterocycles such as pyridines and pyrazoles. The global fluorinated pharmaceutical intermediates market continues to expand, driven by the fact that approximately 20-25% of all pharmaceutical drugs contain at least one fluorine atom.
In the agrochemical sector, the compound is utilized in formulating herbicides and insecticides. It can be employed to develop selective herbicides that target specific weed species without harming crops, and its efficacy in disrupting pest metabolism makes it a candidate for innovative insecticide formulations. The global agrochemical market continues to grow, driven by the need to ensure food security in the face of rising global population, and fluorinated intermediates are playing an increasingly important role in this segment.
In material science and fluorine chemistry, the compound is explored for developing fluorinated polymers known for enhanced thermal stability and chemical resistance. Incorporation of this compound into polymer matrices can lead to materials suitable for high-performance applications in electronics and coatings. It has also served as a reagent in the preparation of specialty materials where fluorine contributes to chemical resistance and altered surface properties. Researchers utilize this compound to study the effects of fluorination on chemical reactivity and material properties. The global fluorinated polymer market, valued in the billions of dollars, demonstrates steady growth driven by demand from aerospace, electronics, and chemical industries.
Major Market Participants
The global supply system for Methyl 3-Amino-4,4,4-Trifluorocrotonate follows a pattern of specialized fine chemical and fluorinated intermediate manufacturers, with production concentrated in China, Europe, India, and North America. The compound is generally supplied as a white to off-white crystalline solid with purity ranging from 97% to ≥99% by HPLC.
Key international suppliers and manufacturers include BOC Sciences (USA), which offers the compound as a standard supplier, and Thermo Scientific, which supplies related fluorinated crotonate derivatives. Chinese manufacturers, including Xinlian Rui Biomedical Technology (Shandong) Co., Ltd., have also entered the market, offering competitive pricing and scalable production.
Shanghai XinChem Co., Ltd. (XinChem) has established a reliable supply chain for high-purity Methyl 3-Amino-4,4,4-Trifluorocrotonate (CAS 107638-19-7). Our product is manufactured under strict quality management, achieving consistent purity (≥98% by HPLC) with low residual solvents and low heavy metals, fully complying with pharmaceutical and agrochemical intermediate standards. It is an ideal building block for fluorinated pharmaceuticals, agrochemicals, and specialty materials.
Regional Market Dynamics
Global demand for Methyl 3-Amino-4,4,4-Trifluorocrotonate shows regional differentiation: “Asia-Pacific dominates production, North America and Europe lead in high-purity R&D and pharmaceutical applications, and Latin America & Middle East/Africa follow as emerging growth markets.” Asia-Pacific, led by China and India, is the world‘s largest producer of fluorinated intermediates and a rapidly growing consumer. China‘s integrated chemical manufacturing base enables cost-effective production of complex fluorinated compounds, with manufacturers offering high-purity material at competitive prices.
North America (United States and Canada) and Europe (Germany, Switzerland, United Kingdom, France) together account for the largest share of high-purity R&D and commercial consumption (≥99%), driven by the highest concentration of fluorinated pharmaceutical drug discovery programs and advanced agrochemical innovation. Customer requirements in these regions are stringent: purity ≥99%, full traceability, ICH Q3D compliance for heavy metals, full impurity profiling (including residual solvents by GC-headspace and related substances by HPLC-UV), and cGMP documentation for pharmaceutical use.
Regulatory and Environmental Considerations
Methyl 3-Amino-4,4,4-Trifluorocrotonate (CAS 107638-19-7) is subject to regulatory oversight in major economies, particularly when intended for pharmaceutical and agrochemical applications. Critical requirements center on purity control, residual solvents, and heavy metal limits.
In the European Union, the compound is subject to REACH regulations; importers and manufacturers must provide Safety Data Sheets (SDS). In the United States, it is regulated under TSCA as a research chemical; for pharmaceutical API use, adherence to cGMP guidelines (21 CFR Parts 210/211) is required. In China, the compound is listed in the Inventory of Existing Chemical Substances (IECSC) and requires safety production licenses for manufacturing facilities.
Environmentally, fluorinated organic compounds require responsible handling and disposal. Manufacturing generates solvent-containing waste streams requiring proper treatment and disposal in accordance with environmental regulations. The compound‘s classification as a potential environmental pollutant means that manufacturers must implement appropriate waste management and emission control measures.
Future Outlook
The market outlook for Methyl 3-Amino-4,4,4-Trifluorocrotonate is tied to three core drivers: (1) sustained growth in global demand for fluorinated pharmaceutical intermediates, driven by the increasing role of fluorine in drug design; (2) rising demand for high-performance agrochemicals to ensure food security; and (3) development of fluorinated polymers and coatings for high-performance applications in electronics and aerospace.
The global fluorinated intermediates market continues to demonstrate significant growth. Available market reports indicate that the broader methyl-3-amino crotonate market is expanding, with comprehensive analyses covering global and Chinese market trends, production capacity, supply/demand dynamics, and import/export statistics. The market for fluorinated building blocks is expected to see sustained growth in the coming years, driven by the expansion of fluorinated pharmaceutical portfolios, development of new agrochemical programs, and growing demand for fluorinated polymers from the electronics and aerospace industries.
Shanghai XinChem Co., Ltd. (XinChem)
As a world-leading supplier of fluorinated organic intermediates, pharmaceutical building blocks, and specialty chemicals, Shanghai XinChem Co., Ltd. (XinChem) has always focused on the innovative needs of the pharmaceutical, agrochemical, and material science industries. Relying on core advantages in multi-step organic synthesis, fluorination chemistry, quality control, and global logistics, we provide high-quality Methyl 3-Amino-4,4,4-Trifluorocrotonate (CAS 107638-19-7) to global customers. Our product is manufactured under strict quality management regimes, achieving consistent specifications for pharmaceutical, agrochemical, and research grades. Fully compliant with international quality standards, it is an ideal fluorinated building block for pharmaceutical synthesis, agrochemical development, and fluorinated polymer research.
1. Technical Advantages
High Purity & Consistency: Our Methyl 3-Amino-4,4,4-Trifluorocrotonate achieves purity levels of ≥98% (verified by HPLC analysis), supplied as a white to off-white crystalline solid, molecular weight 169.1 g/mol, melting point 50-52°C.
Low Impurity Profile: Strict control of residual solvents (<0.5% total), heavy metals (≤10 ppm, ICH Q3D compliant), and related substances by HPLC-UV.
Pharmaceutical-Grade Quality: The compound is tested for full ICH Q3C (residual solvents) and ICH Q3D (heavy metals), with full traceability to primary analytical standards. DMF support is available for pharmaceutical customers.
Batch-to-Batch Uniformity: Rigorous analytical testing (HPLC, NMR, LC-MS, heavy metals by ICP-MS, residual solvents by GC-headspace) guarantees consistent quality and reproducible yields across all production lots.
2. Product Advantages
Versatile Fluorinated β-Enamino Ester: Directly used in the synthesis of fluorinated amino acids, pharmaceutical intermediates (neurological disorder therapeutics, antiviral agents), agrochemical intermediates (herbicides, insecticides), and fluorinated polymers.
Trifluoromethyl Group: Provides enhanced lipophilicity, metabolic stability, and improved bioavailability in final products.
Reactive β-Enamino Ester Functionality: Enables substitution, oxidation, reduction, and condensation reactions for diverse derivatization.
Flexible Packaging Options: 1g, 5g, 10g, 25g, 50g, 100g, 500g, 1kg glass bottles/HDPE containers (R&D/pilot); 5kg, 10kg, 25kg fiber drums (industrial). Full custom packaging available.
Reliable Supply Chain: Annual capacity in the multi-ton range, with dedicated temperature-controlled warehousing (2-8°C, dry, light-protected, sealed containers) and just-in-time delivery capabilities.
3. Application Fields
- Pharmaceutical Intermediates: Synthesis of fluorinated amino acids, neurological disorder therapeutics, antiviral agents, anti-inflammatory drugs, and oncology compounds.
- Agrochemical Intermediates: Synthesis of selective herbicides, insecticides, fungicides, and other crop protection agents.
- Material Science & Fluorine Chemistry: Development of fluorinated polymers with enhanced thermal stability and chemical resistance, coatings and sealants for high-performance applications, and specialty materials.
- Heterocyclic Synthesis: Building block for trifluoromethyl-substituted pyridines, pyrazoles, and other nitrogen-containing heterocycles.
- Fluorine Chemistry Research: Studying the effects of fluorination on chemical reactivity and material properties.
4. Service Support
Our technical team provides full impurity profiling (HPLC purity, residual solvents by GC-headspace, heavy metals by ICP-MS, LC-MS identity confirmation), custom purification to any desired specification, and complete regulatory documentation (Certificate of Analysis, Technical Data Sheet, Safety Data Sheet, REACH compliance, TSCA certification, DMF support for pharmaceutical customers). We also offer custom synthesis of fluorinated derivatives, cold-chain logistics, and just-in-time delivery.
5. Why Choose XinChem
- Professionalism: 20+ years in the pharmaceutical, agrochemical, and fluorochemical industries.
- Flexibility: Tailored to customer purity specifications, packaging sizes, and regulatory documentation requirements.
- Cost-effectiveness: High quality at competitive industrial pricing.
Contact us now to start cooperation!
Website: www.xinchem.com
Email: sales1@xinchem.com
WhatsApp: +86 18049800532
Post time: Jul-05-2026