3,5‑Difluorobromobenzene (also known as 1‑bromo‑3,5‑difluorobenzene, CAS: 461‑96‑1) is a fluorinated aryl halide with the molecular formula C₆H₃BrF₂ and a molecular weight of 192.99 g/mol. It appears as a clear, colorless to light yellow liquid at room temperature with a density of 1.676 g/mL at 25°C, a boiling point of 140°C, and a melting point of –27°C. The compound features a bromine atom at the 1‑position and two fluorine atoms at the 3 and 5 positions on a benzene ring.
As a specialized fluorinated aromatic intermediate, 3,5‑difluorobromobenzene serves as an essential building block in organic synthesis due to its dual functionality: the C–Br bond acts as an efficient handle for palladium‑catalyzed cross‑coupling reactions (such as Suzuki–Miyaura and Buchwald–Hartwig couplings), while the two fluorine atoms enhance metabolic stability and binding affinity in target molecules. Its production typically involves bromination of 1,3‑difluorobenzene or related routes. Market demand is closely linked to the global pharmaceutical, agrochemical, and advanced material industries, driven by the increasing importance of fluorinated intermediates in drug design and the growing demand for high‑performance liquid crystal materials. Based on its chemical characteristics and industrial chain position, this article systematically analyzes international market dynamics of 3,5‑difluorobromobenzene, focusing on core application scenarios, competitive landscape, regional differences, regulatory trends, and future outlook, providing strategic references for industry participants.
Core Application Fields and Demand
Market demand for 3,5‑difluorobromobenzene is concentrated in three major sectors: pharmaceutical synthesis (≈45‑50% of global consumption), agrochemical production (≈25‑30%), and liquid crystals and advanced materials (≈15‑20%), with additional demand from specialty chemical synthesis and research applications (≈5‑10%).
In the pharmaceutical synthesis sector, 3,5‑difluorobromobenzene serves as a key intermediate for the production of several important drug classes. The compound has been used in the synthesis of selective antagonists for GluN2C/GluN2D receptors and COX‑2 inhibitors as anti‑inflammatory and anticancer agents. Derivatives of 1‑bromo‑3,5‑difluorobenzene have been synthesized for use as intermediates in the development of pharmaceutical agents. The 3,5‑difluoro substitution pattern offers distinct metabolic stability and electronic effects compared to other regioisomers, making it particularly valuable for fluorinated API development. The global pharmaceutical intermediate market, valued at approximately USD 45‑47 billion in 2025, is projected to grow at a CAGR of 6‑7% through 2030, sustaining steady demand for fluorinated aryl bromide building blocks.
In the agrochemical production sector, 3,5‑difluorobromobenzene is utilized as a building block for agrochemicals, where the presence of halogen substituents significantly influences its chemical reactivity and biological activity. The fluorine atoms can enhance the metabolic stability and binding affinity of agrochemical molecules, leading to more effective crop protection agents at lower application rates. The growing global population and the resulting need to increase agricultural productivity continue to drive demand for high‑performance agrochemical intermediates. The global agrochemical market is projected to reach USD 120‑130 billion by 2030, supporting sustained demand for fluorinated building blocks.
In the liquid crystals and advanced materials sector, 3,5‑difluorobromobenzene is widely used as an intermediate for liquid crystal materials. The rigid, electron‑deficient aromatic core with fluorine substituents provides desirable optical and mesomorphic properties, making it valuable for the development of advanced display technologies. The global liquid crystal market continues to expand with the growth of consumer electronics and display technologies.
In cross‑coupling chemistry and organic synthesis, 3,5‑difluorobromobenzene serves as a versatile substrate for palladium‑catalyzed coupling reactions. The bromine atom provides a single, predictable coupling site with a 3,5‑difluoro electronic profile, eliminating competing side reactions and enabling predictable Suzuki–Miyaura or Buchwald–Hartwig coupling with no undesired fluoride displacement. This makes it an ideal building block for constructing complex fluorinated aromatic compounds in medicinal chemistry and materials science.
Major Market Participants
The global supply system for 3,5‑difluorobromobenzene follows a pattern of specialized fluorinated intermediate manufacturers, with production concentrated in China, Europe, and North America. The compound is generally supplied as a clear, colorless to light yellow liquid with purity ranging from 97% to ≥99% (verified by GC analysis). Major international suppliers include TCI Chemicals (offering high‑purity material with stock in Asia), Apollo Scientific (manufacturing and supplying worldwide), Thermo Fisher Scientific (Alfa Aesar) (offering 98% purity), AK Scientific (offering >99% purity), BenchChem, BOC Sciences, and CymitQuimica. Chinese manufacturers dominate global supply, with key producers including Bidepharm (offering 97% purity with batch QC), Aromsyn (offering >97% purity with customized synthesis from gram to kilogram scale), Wuhan Xinyang Ruihe Chemical, and Hangzhou Dingxin Technology (offering 99%+ purity).
Shanghai XinChem Co., Ltd. (XinChem) has established a reliable, quality‑controlled supply chain for high‑purity 3,5‑Difluorobromobenzene (CAS 461‑96‑1). Our product is manufactured under strict quality management, achieving consistent purity (≥98‑99%) with low impurity profiles, fully complying with global pharmaceutical, agrochemical, and material science standards. It is available in research grade (for laboratory and R&D applications), industrial grade (for agrochemical and material synthesis), and high‑purity grade (for pharmaceutical and advanced applications).
Regional Market Dynamics
Global demand for 3,5‑difluorobromobenzene shows regional differentiation: “Asia‑Pacific dominates production, North America and Europe lead in high‑purity pharmaceutical and specialty applications, and Latin America and Middle East & Africa are emerging growth regions.”
The global 3,5‑difluorobromobenzene market is the subject of comprehensive industry research, with reports covering market drivers, challenges, supply/demand dynamics, regional overviews (Europe, Asia, North America, etc.), and detailed market predictions.
Asia‑Pacific, particularly China, is the world‘s largest producer and fastest‑growing region for fluorinated aryl bromide intermediates. Chinese manufacturers, including XinChem, offer competitive pricing at scales ranging from research quantities to industrial batches, serving both domestic demand for pharmaceutical and agrochemical intermediates and exports to global markets. The compound is available at competitive prices, with small‑scale R&D quantities available from approximately USD 13‑22 and bulk industrial pricing available upon request.
North America (United States and Canada) and Europe (Germany, Switzerland, United Kingdom, France) together account for the largest share of high‑purity pharmaceutical and specialty consumption (≥99%), driven by the highest concentration of pharmaceutical R&D, agrochemical innovation, and advanced material research. Customer requirements in these regions are stringent: purity ≥98%, full traceability, compliance with REACH and TSCA regulations, and comprehensive impurity documentation.
Japan and South Korea demand ultra‑high‑purity grades for advanced pharmaceutical development and high‑performance liquid crystal applications.
Regulatory and Environmental Considerations
3,5‑Difluorobromobenzene (CAS 461‑96‑1) is subject to regulatory oversight in major economies, particularly when intended for pharmaceutical, agrochemical, and material applications. The compound has an EINECS number of 416‑710‑2. Storage conditions: store in a tightly sealed container in a cool, dry, well‑ventilated area, protected from moisture and incompatible materials. The compound is flammable (flash point 112°F) and should be kept away from heat, sparks, and open flames.
In the European Union, 3,5‑difluorobromobenzene is registered under REACH; importers and manufacturers must provide Safety Data Sheets (SDS). In the United States, the compound is regulated under TSCA as an existing chemical substance; for pharmaceutical API use, adherence to cGMP guidelines (21 CFR Parts 210/211) is required. In China, the compound is listed in the Inventory of Existing Chemical Substances (IECSC) and requires safety production licenses for manufacturing facilities.
Environmentally, fluorinated organic compounds require responsible handling and disposal. Manufacturing processes generate solvent‑containing waste streams requiring proper treatment and disposal in accordance with environmental regulations.
Future Outlook
The market outlook for 3,5‑difluorobromobenzene is tied to three core drivers: (1) sustained growth in global demand for fluorinated pharmaceutical intermediates, driven by the increasing role of fluorine in drug design (particularly in COX‑2 inhibitors, anticancer agents, and GluN2C/D antagonists); (2) rising demand for high‑performance agrochemicals to ensure food security; and (3) expanding applications in liquid crystals and advanced materials for display technologies and optoelectronics. The 3,5‑difluoro substitution pattern offers distinct metabolic stability and electronic effects compared to other regioisomers, positioning this compound as a preferred building block for next‑generation fluorinated molecules.
Challenges include: raw material cost volatility for fluorinating agents and aromatic precursors, competition from alternative fluorinated aryl bromides, and potential regulatory restrictions on certain organofluorine compounds. Enterprises should focus on securing high‑purity (≥99%) production capabilities, maintaining rigorous impurity documentation for global regulatory filings, ensuring compliance with REACH and TSCA requirements, and building long‑term supply partnerships with pharmaceutical manufacturers, agrochemical companies, and advanced material producers.
Shanghai XinChem Co., Ltd. (XinChem)
As a world‑leading supplier of fluorinated organic intermediates, pharmaceutical building blocks, and specialty chemicals, Shanghai XinChem Co., Ltd. (XinChem) has always focused on the innovative needs of the pharmaceutical, agrochemical, and material science industries. Relying on core advantages in organic synthesis, cross‑coupling chemistry, fluorination technology, quality control, and global logistics, we provide high‑quality 3,5‑Difluorobromobenzene (1‑Bromo‑3,5‑difluorobenzene, CAS 461‑96‑1) to global customers. Our product is manufactured under strict quality management, achieving consistent specifications for pharmaceutical, agrochemical, and research grades. Fully compliant with international quality standards, it is an ideal fluorinated aryl bromide building block for pharmaceutical API synthesis, agrochemical development, liquid crystal production, and advanced material applications.
1. Technical Advantages
High Purity & Consistency: Our 3,5‑difluorobromobenzene achieves purity levels of ≥98‑99% (verified by GC analysis), supplied as a clear, colorless to light yellow liquid, molecular weight 192.99 g/mol, density 1.676 g/mL at 25°C, boiling point 140°C, melting point –27°C.
Low Impurity Profile: Strict control of residual solvents, heavy metals, and related substances ensures high performance for pharmaceutical, agrochemical, and material applications.
Multiple Grades Available: We offer research grade (for laboratory and R&D applications), industrial grade (for agrochemical and material synthesis), and high‑purity grade (for pharmaceutical and advanced applications).
Batch‑to‑Batch Uniformity: Rigorous analytical testing (GC, GC‑MS, density, refractive index) guarantees consistent quality and reproducible performance across all production lots.
2. Product Advantages
Versatile Fluorinated Aryl Bromide Building Block: Directly used in pharmaceutical synthesis (COX‑2 inhibitors, anticancer agents, GluN2C/GluN2D antagonists), agrochemical production (herbicides, fungicides, pesticides), liquid crystals and display technologies, and cross‑coupling reactions (Suzuki–Miyaura, Buchwald–Hartwig).
Dual Functionality: The C–Br bond provides an efficient handle for palladium‑catalyzed cross‑coupling, while the 3,5‑difluoro pattern offers distinct metabolic stability and electronic effects.
Predictable Reactivity: Single bromine coupling site eliminates competing side reactions and enables predictable Suzuki–Miyaura or Buchwald–Hartwig coupling with no undesired fluoride displacement.
Flexible Packaging: 1g, 5g, 10g, 25g, 50g, 100g, 500g (R&D); 1kg, 5kg, 10kg, 25kg, 50kg HDPE drums/steel drums (industrial); full custom packaging available.
Reliable Supply Chain: Annual capacity in the multi‑ton range, with dedicated warehousing (cool, dry, light‑protected, sealed containers, flammable storage) and just‑in‑time delivery capabilities.
3. Application Fields
- Pharmaceutical Synthesis: COX‑2 inhibitors (anti‑inflammatory agents), anticancer agents, GluN2C/GluN2D antagonists, and other fluorinated APIs.
- Agrochemical Production: Herbicides, fungicides, pesticides, and crop protection agents.
- Liquid Crystals & Advanced Materials: Liquid crystal formulations for LCD and OLED display technologies.
- Cross‑Coupling Chemistry: Suzuki–Miyaura and Buchwald–Hartwig couplings for constructing complex fluorinated aromatic compounds.
- Organic Synthesis: Building block for functionalized fluorinated terphenyls and other advanced intermediates.
4. Service Support
Our technical team provides cross‑coupling reaction guidance, application optimization recommendations, impurity profiling, and regulatory documentation (Certificate of Analysis, Technical Data Sheet, Safety Data Sheet, REACH compliance, TSCA certification). We offer custom packaging and just‑in‑time delivery.
5. Why Choose XinChem
- Professionalism: 20+ years in the pharmaceutical, agrochemical, and fluorochemical industries.
- Flexibility: Tailored to customer purity specifications, grade requirements, packaging sizes, and regulatory documentation needs.
- Cost‑effectiveness: High quality at competitive industrial pricing.
Contact us now to start cooperation!
Website: www.xinchem.com
Email: sales1@xinchem.com
WhatsApp: +86 18049800532
Post time: Jul-22-2026