4‑Bromo‑2‑fluoroanisole (also known as 4‑bromo‑2‑fluoro‑1‑methoxybenzene, 1‑bromo‑3‑fluoro‑4‑methoxybenzene, CAS: 2357‑52‑0) is a halogenated aromatic ether with the molecular formula C₇H₆BrFO and a molecular weight of 205.02 g/mol. It features a methoxy group at position 1, a fluorine atom at position 2, and a bromine atom at position 4 on the benzene ring, creating a 1,2,4‑substitution pattern that enables orthogonal reactivity. The compound appears as a colorless to pale yellow liquid at room temperature, with a melting point of 16 °C, a boiling point of 215.1 °C at 760 mmHg, and a density of 1.59 g/mL at 25 °C.
As a specialized fluorinated aromatic intermediate, 4‑bromo‑2‑fluoroanisole serves as an essential building block in organic synthesis due to its dual functionality: the bromine atom serves as a reactive site for palladium‑catalyzed cross‑coupling reactions (such as Suzuki–Miyaura, Sonogashira, Heck, and Buchwald–Hartwig couplings), while the fluorine atom modulates the electronic environment of the aromatic ring and enhances lipophilicity and metabolic stability in target molecules. The methoxy group provides additional electronic effects and can be further functionalized or demethylated as needed. This unique combination of three distinct functional groups makes 4‑bromo‑2‑fluoroanisole a valuable intermediate for constructing complex molecular architectures. Its production typically involves bromination of 2‑fluoroanisole or related routes. Market demand is closely linked to the global pharmaceutical, agrochemical, and advanced material industries, driven by the increasing importance of fluorinated intermediates in drug design and the growing demand for high‑performance liquid crystal materials. Based on its chemical characteristics and industrial chain position, this article systematically analyzes international market dynamics of 4‑bromo‑2‑fluoroanisole, focusing on core application scenarios, competitive landscape, regional differences, regulatory trends, and future outlook, providing strategic references for industry participants.
Core Application Fields and Demand
Market demand for 4‑bromo‑2‑fluoroanisole is concentrated in three major sectors: pharmaceutical synthesis (≈40‑45% of global consumption), agrochemical production (≈20‑25%), and liquid crystals and advanced materials (≈15‑20%), with additional demand from dyes, fragrances, and specialty chemical synthesis (≈10‑15%).
In the pharmaceutical synthesis sector, 4‑bromo‑2‑fluoroanisole serves as a valuable building block for the development of various drug candidates. The compound has been used in the synthesis of 1,4‑bis[(3′‑fluoro‑4′‑n‑alkoxyphenyl)ethynyl]benzenes and other complex organic molecules. It is also utilized in the synthesis of 7‑fluoro‑6‑methoxy‑1‑methyl‑2‑naphthaldehyde and 5,7‑difluoro‑6‑methoxy‑1‑methyl‑2‑naphthaldehyde. The presence of bromine enables efficient cross‑coupling for constructing diverse molecular scaffolds, while fluorine enhances pharmacokinetic properties. The global pharmaceutical intermediate market, valued at approximately USD 45‑47 billion in 2025, is projected to grow at a CAGR of 6‑7% through 2030, sustaining steady demand for fluorinated building blocks.
In the agrochemical production sector, 4‑bromo‑2‑fluoroanisole is utilized as a building block for herbicides, fungicides, and other crop protection agents. The incorporation of fluorine and bromine substituents into agrochemical molecules can enhance their metabolic stability, lipophilicity, and biological activity, leading to more effective crop protection agents at lower application rates. The growing global population and the resulting need to increase agricultural productivity continue to drive demand for high‑performance agrochemical intermediates.
In the liquid crystals and advanced materials sector, 4‑bromo‑2‑fluoroanisole is widely used as an intermediate for liquid crystal materials. It has been employed in the synthesis of liquid crystals with a terminal difluoromethoxy group and a phenylbicyclohexane backbone. The rigid, electron‑deficient aromatic core with fluorine and methoxy substituents provides desirable optical and mesomorphic properties, making it valuable for the development of advanced display technologies. The global liquid crystal market continues to expand with the growth of consumer electronics and display technologies.
In cross‑coupling chemistry and organic synthesis, 4‑bromo‑2‑fluoroanisole serves as a versatile substrate for palladium‑catalyzed coupling reactions. The bromine atom provides a single, predictable coupling site, while the fluorine atom and methoxy group modulate the electronic environment of the ring, enabling selective functionalization. This makes it an ideal building block for constructing complex fluorinated aromatic compounds in medicinal chemistry and materials science.
In dyes and fragrances, 4‑bromo‑2‑fluoroanisole is used as an intermediate for producing high‑value fine chemicals, where the compound‘s unique substitution pattern enhances the performance characteristics of dyes and fragrance compounds.
Major Market Participants
The global supply system for 4‑bromo‑2‑fluoroanisole follows a pattern of specialized fluorinated intermediate manufacturers, with production concentrated in China, Europe, and North America. The compound is generally supplied as a colorless to light yellow clear liquid with purity ranging from 97% to ≥99% (verified by GC analysis). Major international suppliers include TCI Chemicals (offering >98.0% purity with stock in Asia), Sigma‑Aldrich (offering 97% purity, Cat. No. 293474), Chem‑Impex (offering ≥98% purity), AK Scientific (offering 98% purity), BenchChem, BOC Sciences, and CymitQuimica. Chinese manufacturers dominate global supply, with key producers including Hangzhou Dingxin Technology (offering 99%+ purity), Aromsyn (offering >97% purity with customized synthesis from gram to kilogram scale), Bidepharm (offering 98% purity), and Shanghai Coolpharm (offering 98% purity).
Shanghai XinChem Co., Ltd. (XinChem) has established a reliable, quality‑controlled supply chain for high‑purity 4‑Bromo‑2‑fluoroanisole (CAS 2357‑52‑0). Our product is manufactured under strict quality management, achieving consistent purity (≥98‑99%) with low impurity profiles, fully complying with global pharmaceutical, agrochemical, and material science standards. It is available in research grade (for laboratory and R&D applications), industrial grade (for agrochemical and material synthesis), and high‑purity grade (for pharmaceutical and advanced applications).
Regional Market Dynamics
Global demand for 4‑bromo‑2‑fluoroanisole shows regional differentiation: “Asia‑Pacific dominates production, North America and Europe lead in high‑purity pharmaceutical and specialty applications, and Latin America and Middle East & Africa are emerging growth regions.”
The global 4‑bromo‑2‑fluoroanisole market is the subject of comprehensive industry research, with reports covering market drivers, challenges, supply/demand dynamics, regional overviews (Europe, Asia, North America, Latin America, etc.), and detailed market predictions.
Asia‑Pacific, particularly China, is the world‘s largest producer and fastest‑growing region for fluorinated aromatic intermediates. Chinese manufacturers, including XinChem, offer competitive pricing at scales ranging from research quantities to industrial batches, serving both domestic demand for pharmaceutical and agrochemical intermediates and exports to global markets. The compound is available at competitive prices, with R&D quantities from approximately USD 35‑139 (100‑500g) and bulk industrial pricing available upon request.
North America (United States and Canada) and Europe (Germany, Switzerland, United Kingdom, France) together account for the largest share of high‑purity pharmaceutical and specialty consumption (≥99%), driven by the highest concentration of pharmaceutical R&D, agrochemical innovation, and advanced material research. Customer requirements in these regions are stringent: purity ≥98%, full traceability, compliance with REACH and TSCA regulations, and comprehensive impurity documentation.
Japan and South Korea demand ultra‑high‑purity grades for advanced pharmaceutical development and high‑performance liquid crystal applications.
Regulatory and Environmental Considerations
4‑Bromo‑2‑fluoroanisole (CAS 2357‑52‑0) is subject to regulatory oversight in major economies, particularly when intended for pharmaceutical, agrochemical, and material applications. The compound has an MDL number MFCD00011710. Storage conditions: store in a tightly sealed container in a cool, dark place (recommended below 15 °C), protected from moisture and incompatible materials. The compound is classified as a combustible liquid (Storage Class Code 10) with a flash point of 98 °C (closed cup). GHS hazard statements include: H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation).
In the European Union, 4‑bromo‑2‑fluoroanisole is registered under REACH; importers and manufacturers must provide Safety Data Sheets (SDS). In the United States, the compound is regulated under TSCA as an existing chemical substance; for pharmaceutical API use, adherence to cGMP guidelines (21 CFR Parts 210/211) is required. In China, the compound is listed in the Inventory of Existing Chemical Substances (IECSC) and requires safety production licenses for manufacturing facilities.
Environmentally, halogenated organic compounds require responsible handling and disposal. Manufacturing processes generate solvent‑containing waste streams requiring proper treatment and disposal in accordance with environmental regulations.
Future Outlook
The market outlook for 4‑bromo‑2‑fluoroanisole is tied to three core drivers: (1) sustained growth in global demand for fluorinated pharmaceutical intermediates, driven by the increasing role of fluorine in drug design and the compound‘s utility in synthesizing complex molecular scaffolds; (2) rising demand for high‑performance agrochemicals to ensure food security; and (3) expanding applications in liquid crystals and advanced materials for display technologies and optoelectronics. The 1,2,4‑substitution pattern offers orthogonal reactivity that positions this compound as a preferred building block for next‑generation fluorinated molecules.
Challenges include: raw material cost volatility for brominating and fluorinating agents, competition from alternative fluorinated aryl bromides, and potential regulatory restrictions on certain halogenated compounds. Enterprises should focus on securing high‑purity (≥99%) production capabilities, maintaining rigorous impurity documentation for global regulatory filings, ensuring compliance with REACH and TSCA requirements, and building long‑term supply partnerships with pharmaceutical manufacturers, agrochemical companies, and advanced material producers.
Shanghai XinChem Co., Ltd. (XinChem)
As a world‑leading supplier of fluorinated organic intermediates, pharmaceutical building blocks, and specialty chemicals, Shanghai XinChem Co., Ltd. (XinChem) has always focused on the innovative needs of the pharmaceutical, agrochemical, and material science industries. Relying on core advantages in organic synthesis, cross‑coupling chemistry, fluorination technology, quality control, and global logistics, we provide high‑quality 4‑Bromo‑2‑fluoroanisole (CAS 2357‑52‑0) to global customers. Our product is manufactured under strict quality management, achieving consistent specifications for pharmaceutical, agrochemical, and research grades. Fully compliant with international quality standards, it is an ideal fluorinated aromatic building block for pharmaceutical API synthesis, agrochemical development, liquid crystal production, and advanced material applications.
1. Technical Advantages
High Purity & Consistency: Our 4‑bromo‑2‑fluoroanisole achieves purity levels of ≥98‑99% (verified by GC analysis), supplied as a colorless to light yellow clear liquid, molecular weight 205.02 g/mol, density 1.59 g/mL at 25 °C, refractive index n20/D 1.545.
Low Impurity Profile: Strict control of residual solvents, heavy metals, and related substances ensures high performance for pharmaceutical, agrochemical, and material applications.
Multiple Grades Available: We offer research grade (for laboratory and R&D applications), industrial grade (for agrochemical and material synthesis), and high‑purity grade (for pharmaceutical and advanced applications).
Batch‑to‑Batch Uniformity: Rigorous analytical testing (GC, GC‑MS, density, refractive index) guarantees consistent quality and reproducible performance across all production lots.
2. Product Advantages
Versatile Fluorinated Aromatic Building Block: Directly used in pharmaceutical synthesis, agrochemical production (herbicides, fungicides, pesticides), liquid crystals and display technologies, dyes, fragrances, and cross‑coupling reactions (Suzuki–Miyaura, Sonogashira, Heck, Buchwald–Hartwig).
Orthogonal Reactivity: The 1,2,4‑substitution pattern (Br at C4, F at C2, OCH₃ at C1) enables selective functionalization and sequential cross‑coupling.
Predictable Reactivity: Single bromine coupling site eliminates competing side reactions and enables predictable cross‑coupling with no undesired side products.
Flexible Packaging: 1g, 5g, 10g, 25g, 50g, 100g, 500g (R&D); 1kg, 5kg, 10kg, 25kg, 50kg HDPE drums/steel drums (industrial); full custom packaging available.
Reliable Supply Chain: Annual capacity in the multi‑ton range, with dedicated warehousing (cool, dark, <15 °C, sealed containers) and just‑in‑time delivery capabilities.
3. Application Fields
- Pharmaceutical Synthesis: Building block for drug candidates, 1,4‑bis[(3′‑fluoro‑4′‑n‑alkoxyphenyl)ethynyl]benzenes, naphthaldehyde derivatives, and other fluorinated APIs.
- Agrochemical Production: Herbicides, fungicides, pesticides, and crop protection agents.
- Liquid Crystals & Advanced Materials: Liquid crystal formulations for LCD and OLED display technologies.
- Cross‑Coupling Chemistry: Suzuki–Miyaura, Sonogashira, Heck, and Buchwald–Hartwig couplings for constructing complex fluorinated aromatic compounds.
- Dyes & Fragrances: Specialty dyes, fragrances, and fine chemicals.
- Material Science: Polymers, coatings, and advanced materials.
4. Service Support
Our technical team provides cross‑coupling reaction guidance, application optimization recommendations, impurity profiling, and regulatory documentation (Certificate of Analysis, Technical Data Sheet, Safety Data Sheet, REACH compliance, TSCA certification). We offer custom packaging and just‑in‑time delivery.
5. Why Choose XinChem
- Professionalism: 20+ years in the pharmaceutical, agrochemical, and fluorochemical industries.
- Flexibility: Tailored to customer purity specifications, grade requirements, packaging sizes, and regulatory documentation needs.
- Cost‑effectiveness: High quality at competitive industrial pricing.
Contact us now to start cooperation!
Website: www.xinchem.com
Email: sales1@xinchem.com
WhatsApp: +86 18049800532
Post time: Jul-22-2026