4‑Bromo‑2‑fluoro‑1‑vinylbenzene (also known as 4‑bromo‑2‑fluorostyrene, 1‑bromo‑4‑ethenyl‑3‑fluorobenzene, CAS: 627463‑17‑6) is a fluorinated vinyl aromatic compound with the molecular formula C₈H₆BrF and a molecular weight of 201.04 g/mol. It appears as a clear, colorless to faint yellow liquid with a calculated density of 1.481 g/cm³, a boiling point of 208.8 °C at 760 mmHg, and a flash point of 82.8 °C. The compound is slightly soluble in water but readily soluble in organic solvents such as alcohols, ethers, and ketones. Its structure combines three reactive handles — a vinyl group (-CH=CH₂) available for polymerization and Heck coupling, a bromine atom serving as an effective leaving group for cross‑coupling reactions (Suzuki–Miyaura, Stille, Buchwald–Hartwig), and a fluorine atom that enhances lipophilicity, metabolic stability, and bioavailability in final products.
As a fluorinated styrene derivative, 4‑bromo‑2‑fluoro‑1‑vinylbenzene is a key building block for the synthesis of complex organic molecules, pharmaceutical intermediates, agrochemicals, liquid crystals, and functional polymers. Its unique 1‑bromo‑3‑fluoro‑4‑vinyl substitution pattern imparts distinct chemical and physical properties that cannot be replicated by other regioisomers, making it a valuable intermediate in medicinal chemistry and materials science. Market demand is closely linked to the global expansion of fluorinated pharmaceuticals, the growing need for high‑performance agrochemicals, and the increasing adoption of cross‑coupling chemistry in organic synthesis. Based on its chemical characteristics and industrial chain position, this article systematically analyzes international market dynamics of 4‑bromo‑2‑fluoro‑1‑vinylbenzene, focusing on core application scenarios, competitive landscape, regional differences, regulatory trends, and future outlook, providing strategic references for industry participants.
Core Application Fields and Demand
Market demand for 4‑bromo‑2‑fluoro‑1‑vinylbenzene is concentrated in three major sectors: pharmaceutical synthesis and API development (≈45‑50% of global consumption), agrochemical synthesis and material science (≈25‑30%), and organic synthesis and cross‑coupling reactions (≈15‑20%), with additional demand from liquid crystal and functional polymer manufacturers (≈5‑10%).
In the pharmaceutical synthesis and API development sector, this compound serves as a key building block for the preparation of biologically active molecules. The mechanism of action involves electrophilic aromatic substitution, where the compound forms a sigma‑bond with the benzene ring, generating a positively charged benzenonium intermediate that undergoes further transformations. The vinyl group can participate in cross‑coupling reactions (Heck reaction), while the bromine atom serves as an effective leaving group for Suzuki–Miyaura, Stille, and Buchwald–Hartwig couplings. The fluorine atom enhances lipophilicity and metabolic stability — critical features in modern drug design, with approximately 20‑25% of all pharmaceuticals containing at least one fluorine atom. Compounds containing this building block exhibit anti‑proliferative activity and are useful for treating or controlling cancer, particularly solid tumors. The compound is also employed in the synthesis of other biologically active compounds, including antiviral and anti‑inflammatory agents. The compound has been classified as a fluorinated pharmaceutical intermediate, a category that continues to see strong growth in both established and emerging markets.
In the agrochemical synthesis sector, 4‑bromo‑2‑fluoro‑1‑vinylbenzene is used for the development and production of high‑performance crop protection agents. The vinyl group and bromine atom enable further functionalization to create biologically active compounds targeting specific weed species, pests, and pathogens without harming crops. The fluorine atom imparts enhanced resistance to metabolic degradation and improved penetration through plant and insect cuticles, making agrochemicals more effective at lower application rates. The global agrochemical market continues to grow, driven by the need to ensure food security in the face of rising global population, and fluorinated intermediates are playing an increasingly important role in this segment.
In the organic synthesis and cross‑coupling reactions sector, 4‑bromo‑2‑fluoro‑1‑vinylbenzene is widely used as a versatile building block for Suzuki–Miyaura, Heck, and Stille cross‑couplings. A novel method has been reported for the synthesis of 2‑azaaryl tetrahydroquinolines via the base‑promoted tandem reaction of azaaryl methyl amines with styrene derivatives (over 30 examples, yields up to 95%). The vinyl group and bromine atom make this compound a valuable intermediate for the synthesis of complex organic molecules and compound libraries for high‑throughput screening. The compound also finds application in the synthesis of fluorinated polymers characterized by enhanced thermal stability and chemical resistance. Incorporation into polymer matrices enables materials suitable for high‑performance applications in electronics and coatings. In materials science, the compound is used for the development of liquid crystals and functional materials with tailored optical and electronic properties.
Major Market Participants
The global supply system for 4‑bromo‑2‑fluoro‑1‑vinylbenzene follows a pattern of specialized fluorinated organic intermediate manufacturers, with production concentrated in China, Europe, India, and North America. The compound is generally supplied as a clear to faint yellow liquid with purity ranging from 95% to ≥98% (verified by GC analysis). Major international suppliers include Fluorochem (UK, purity 98%, pack sizes 1 g and 5 g with UK, Germany, and China stock), AK Scientific (USA, purity 95%), SynQuest Labs (USA), Zylexa Pharma (UK), International Laboratory (USA), CymitQuimica (Spain, purity 99%), BenchChem (USA), and Fluoropharm. The compound is also available from Chinese manufacturers including XinChem, which offer competitive pricing for both R&D and industrial scales.
Shanghai XinChem Co., Ltd. (XinChem) has established a reliable, quality‑controlled supply chain for high‑purity 4‑bromo‑2‑fluoro‑1‑vinylbenzene (CAS 627463‑17‑6). Our product is manufactured under strict quality management, achieving consistent purity (≥95‑98% by GC) with low residual solvents and low heavy metals, fully complying with pharmaceutical and agrochemical intermediate standards. It is an ideal fluorinated vinyl building block for pharmaceutical API synthesis, agrochemical development, liquid crystal production, and functional polymer research.
Regional Market Dynamics
Global demand for 4‑bromo‑2‑fluoro‑1‑vinylbenzene shows regional differentiation: “Asia‑Pacific dominates production, North America and Europe lead in high‑purity R&D and pharmaceutical applications, and Latin America & Middle East/Africa follow as emerging growth markets.”
Asia‑Pacific, particularly China, is the world‘s largest producer and fastest‑growing region for fluorinated organic intermediates. Chinese manufacturers, including XinChem, offer competitive pricing at scales ranging from research quantities to industrial batches, serving both domestic demand for pharmaceutical and agrochemical intermediates and exports to Southeast Asia, Europe, and North America. China possesses a well‑developed infrastructure for fluorochemical production, with integrated supply chains for fluorinated building blocks.
North America (United States and Canada) and Europe (Germany, United Kingdom, Switzerland, France) together account for the largest share of high‑purity R&D consumption (≥98%), driven by the highest concentration of fluorinated pharmaceutical drug discovery programs, agrochemical innovation, and advanced materials research. Customer requirements in these regions are stringent: purity ≥98%, full traceability, ICH Q3D compliance for heavy metals, full impurity profiling, and cGMP documentation for pharmaceutical use.
Japan and South Korea demand ultra‑high‑purity grades for advanced pharmaceutical development and high‑performance liquid crystal applications.
Regulatory and Environmental Considerations
4‑Bromo‑2‑fluoro‑1‑vinylbenzene (CAS 627463‑17‑6) is classified as a harmful/irritant substance with GHS07 pictogram and signal word Warning. Hazard statements include: H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Precautionary measures include wearing protective gloves, protective clothing, and eye/face protection (P280), washing thoroughly after handling (P264), using only outdoors or in a well‑ventilated area (P271), and storing in a well‑ventilated place with the container tightly closed (P403+P233). The compound is not classified as a hazardous material for transport (non‑hazardous shipping). It is flammable and should be kept away from ignition sources, high temperatures, and oxidizing agents. Long‑term storage is recommended in a cool, dry place.
In the European Union, the compound is subject to REACH regulations; importers and manufacturers must provide Safety Data Sheets (SDS). In the United States, it is regulated under TSCA as a research chemical; for pharmaceutical API use, adherence to cGMP guidelines (21 CFR Parts 210/211) is required. In China, the compound is listed in the Inventory of Existing Chemical Substances (IECSC) and requires safety production licenses for manufacturing facilities. Environmentally, fluorinated organic compounds require responsible handling and disposal; manufacturing generates solvent‑containing waste streams requiring proper treatment.
Future Outlook
The market outlook for 4‑bromo‑2‑fluoro‑1‑vinylbenzene is tied to four core drivers: (1) sustained growth in global demand for fluorinated pharmaceutical intermediates, driven by the increasing role of fluorine in drug design; (2) rising demand for high‑performance agrochemicals to ensure food security; (3) development of liquid crystals and functional polymers for high‑performance applications in electronics and materials science; and (4) the expanding use of cross‑coupling reactions in organic synthesis for constructing complex molecular architectures. Available market reports covering global and regional trends, manufacturers, distributors, and pricing are accessible through specialized industry research platforms.
The fluorinated intermediates market continues to demonstrate significant growth. The compound is available from multiple international suppliers with competitive pricing, and Chinese manufacturers continue to expand production capacity to meet growing global demand. The expansion of fluorinated pharmaceutical portfolios, development of new agrochemical programs, and growing demand for fluorinated polymers from the electronics and aerospace industries will ensure sustained growth in the coming years.
Shanghai XinChem Co., Ltd. (XinChem)
As a world‑leading supplier of fluorinated organic intermediates, pharmaceutical building blocks, and specialty chemicals, Shanghai XinChem Co., Ltd. (XinChem) has always focused on the innovative needs of the pharmaceutical, agrochemical, and material science industries. Relying on core advantages in multi‑step organic synthesis, cross‑coupling chemistry, quality control, and global logistics, we provide high‑quality 4‑Bromo‑2‑fluoro‑1‑vinylbenzene (4‑Bromo‑2‑fluorostyrene, CAS 627463‑17‑6) to global customers. Our product is manufactured under strict quality management, achieving consistent specifications for pharmaceutical, agrochemical, and research grades. Fully compliant with international quality standards, it is an ideal fluorinated vinyl building block for pharmaceutical API synthesis, agrochemical development, liquid crystal production, and functional polymer research.
1. Technical Advantages
High Purity & Consistency: Our 4‑bromo‑2‑fluoro‑1‑vinylbenzene achieves purity levels of ≥95‑98% (verified by GC analysis), supplied as a clear to faint yellow liquid, molecular weight 201.04 g/mol, density 1.481 g/cm³ (calculated), boiling point 208.8 °C at 760 mmHg, flash point 82.8 °C, refractive index 1.575 (calculated).
Low Impurity Profile: Strict control of residual solvents (<0.5% total), heavy metals (≤10 ppm, ICH Q3D compliant), and related substances by GC‑FID.
Pharmaceutical‑Grade Quality: The compound is tested for full ICH Q3C (residual solvents) and ICH Q3D (heavy metals), with full traceability to primary analytical standards. DMF support is available for pharmaceutical customers.
Batch‑to‑Batch Uniformity: Rigorous analytical testing (GC, NMR, LC‑MS, heavy metals by ICP‑MS, residual solvents by GC‑headspace) guarantees consistent quality and reproducible yields across all production lots.
2. Product Advantages
Versatile Fluorinated Vinyl Building Block: Directly used in the synthesis of pharmaceutical APIs (anti‑proliferative agents for solid tumors, antiviral, anti‑inflammatory), agrochemical intermediates (herbicides, insecticides, fungicides), liquid crystals, and functional polymers.
Three Reactive Handles: Vinyl group (-CH=CH₂) for polymerization and Heck cross‑coupling; bromine atom for Suzuki–Miyaura, Stille, and Buchwald–Hartwig cross‑couplings; fluorine atom for enhanced lipophilicity, metabolic stability, and bioavailability.
Unique Substitution Pattern: The specific 1‑bromo‑3‑fluoro‑4‑vinyl substitution pattern imparts distinct chemical and physical properties, making it valuable in various research and industrial applications.
Flexible Packaging Options: 1 g, 5 g, 10 g, 25 g, 50 g, 100 g (glass vials for R&D); 500 g, 1 kg (HDPE containers for pilot batches); 5 kg, 10 kg, 25 kg (fiber drums for industrial batches). Full custom packaging available.
Reliable Supply Chain: Annual capacity in the multi‑ton range, with dedicated temperature‑controlled warehousing (2‑8°C, dry, light‑protected, sealed containers) and just‑in‑time delivery capabilities.
3. Application Fields
- Pharmaceutical Intermediates: Synthesis of anti‑proliferative agents (solid tumor therapy), antiviral agents, anti‑inflammatory drugs, and protein kinase inhibitors.
- Agrochemical Intermediates: Synthesis of selective herbicides, insecticides, fungicides, and other crop protection agents.
- Material Science & Liquid Crystals: Development of fluorinated polymers with enhanced thermal stability and chemical resistance, liquid crystals, and functional materials with tailored optical and electronic properties.
- Cross‑Coupling Reactions: Building block for Suzuki–Miyaura, Heck, Stille, and Buchwald–Hartwig couplings; synthesis of compound libraries for high‑throughput screening.
- Fluorinated Polymer Research: Monomer for specialty polymers with enhanced chemical resistance and surface properties.
4. Service Support
Our technical team provides full impurity profiling (GC purity, residual solvents by GC‑headspace, heavy metals by ICP‑MS, LC‑MS identity confirmation), custom purification to any desired specification, and complete regulatory documentation (Certificate of Analysis, Technical Data Sheet, Safety Data Sheet, REACH compliance, TSCA certification, DMF support for pharmaceutical customers). We also offer custom synthesis of fluorinated derivatives, cold‑chain logistics, and just‑in‑time delivery.
5. Why Choose XinChem
- Professionalism: 20+ years in the pharmaceutical, agrochemical, and fluorochemical industries.
- Flexibility: Tailored to customer purity specifications, packaging sizes, and regulatory documentation requirements.
- Cost‑effectiveness: High quality at competitive industrial pricing.
Contact us now to start cooperation!
Website: www.xinchem.com
Email: sales1@xinchem.com
WhatsApp: +86 18049800532
Post time: Jul-05-2026