5-Bromo-2-fluoropyridine (CAS: 766-11-0) is a halogenated heterocyclic compound with the molecular formula C₅H₃BrFN and a molecular weight of 175.99 g/mol. It appears as a colorless to light yellow clear liquid at room temperature, with a boiling point of 63°C at 15 mmHg. The structure consists of a pyridine ring bearing a bromine atom at the 5-position and a fluorine atom at the 2-position — a substitution pattern that creates two distinct reactive sites amenable to orthogonal functionalization.
As a specialized halogenated pyridine intermediate, 5-bromo-2-fluoropyridine serves as an essential building block in organic synthesis due to its dual reactivity: the bromine atom at the 5-position is well-suited for palladium- or copper-catalyzed cross-coupling reactions (such as Suzuki–Miyaura and Buchwald–Hartwig couplings), while the fluorine at the 2-position is activated towards nucleophilic aromatic substitution (SNAr). This orthogonal reactivity enables sequential functionalization without intervening purification steps, making it a valuable platform for constructing complex molecular architectures. Its production typically involves halogenation of pyridine derivatives or related routes. Market demand is closely linked to the global pharmaceutical, agrochemical, and advanced material industries, driven by the increasing importance of halogenated heterocycles in drug design and the growing demand for high-performance liquid crystal materials. Based on its chemical characteristics and industrial chain position, this article systematically analyzes international market dynamics of 5-bromo-2-fluoropyridine, focusing on core application scenarios, competitive landscape, regional differences, regulatory trends, and future outlook, providing strategic references for industry participants.
Core Application Fields and Demand
Market demand for 5-bromo-2-fluoropyridine is concentrated in three major sectors: pharmaceutical synthesis (≈45-50% of global consumption), agrochemical production (≈25-30%), and advanced materials & liquid crystals (≈15-20%), with additional demand from specialty chemical synthesis and research applications (≈5-10%).
In the pharmaceutical synthesis sector, 5-bromo-2-fluoropyridine serves as a molecular scaffold for many active pharmaceutical ingredients (APIs). It has been used in the development of inhibitors of neuropeptide Y receptor Y5, inhibitors of the main protease of SARS-CoV-2, and inhibitors of indoleamine-2,3-dioxygenase-1 (IDO1) in cancer immunotherapy. The compound is also employed in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands for vesicular acetylcholine transport, as well as benzo[3,2-d]furanopyrimidin-2-one derivatives. The distinct reactivity of its two halogen substituents enables the generation of pentasubstituted pyridines with desired functionalities for drug development. The global pharmaceutical intermediate market, valued at approximately USD 45-47 billion in 2025, is projected to grow at a CAGR of 6-7% through 2030, sustaining steady demand for halogenated heterocyclic building blocks.
In the agrochemical production sector, 5-bromo-2-fluoropyridine is widely used as a building block for the synthesis of herbicides, insecticides, and fungicides. The compound’s high reactivity and polarity make it an ideal precursor for designing new molecules with improved efficacy, selectivity, and safety profiles. The introduction of halogenated heterocycles into agrochemical molecules can enhance their biological activity and environmental profile. The growing global population and the resulting need to increase agricultural productivity continue to drive demand for high-performance agrochemical intermediates. The global agrochemical market is projected to reach USD 120-130 billion by 2030, supporting sustained demand for halogenated building blocks.
In the advanced materials & liquid crystals sector, 5-bromo-2-fluoropyridine is used as a precursor for OLED and liquid crystal development. The rigid, electron-deficient pyridine core with halogen substituents provides desirable optical and electronic properties, making it valuable for the development of advanced display technologies and organic electronic materials. The global fluoropyridines market, valued at approximately USD 83-94 million in 2025, is projected to grow at a CAGR of 6.8-7.0% through 2032.
In cross-coupling chemistry and organic synthesis, 5-bromo-2-fluoropyridine serves as a model substrate for exploring the efficiency and selectivity of successive SNAr substitution reactions and transition-metal-catalyzed cross-coupling reactions. The electron-withdrawing fluorine activates the adjacent bromine for high-fidelity Suzuki-Miyaura cross-coupling at the 5-position. The compound easily reacts with amines to synthesize halogenated pyridine and pyrimidine derivatives, making it an ideal building block for constructing complex fluorinated heterocyclic compounds in medicinal chemistry and materials science.
Major Market Participants
The global supply system for 5-bromo-2-fluoropyridine follows a pattern of specialized halogenated intermediate manufacturers, with production concentrated in China, Europe, and North America. The compound is generally supplied as a colorless to light yellow clear liquid with purity ranging from 98% to ≥99% (verified by GC analysis). Major international suppliers include TCI Chemicals (offering >98.0% purity with stock in Asia), Thermo Fisher Scientific (Acros Organics) (offering 99% purity), Apollo Scientific (offering high-purity material), and BenchChem. Chinese manufacturers dominate global supply, with key producers including Bidepharm (offering 98% purity with batch QC documentation), Shanghai Coolpharm (offering 98% purity), Shanghai Yuanye Biotechnology, and Wuhan Fortuna Chemical.
Shanghai XinChem Co., Ltd. (XinChem) has established a reliable, quality-controlled supply chain for high-purity 5-Bromo-2-fluoropyridine (CAS 766-11-0). Our product is manufactured under strict quality management, achieving consistent purity (≥98-99%) with low impurity profiles, fully complying with global pharmaceutical, agrochemical, and material science standards. It is available in research grade (for laboratory and R&D applications), industrial grade (for agrochemical and material synthesis), and high-purity grade (for pharmaceutical and advanced applications). Custom synthesis from gram to kilogram scale is available upon request.
Regional Market Dynamics
Global demand for 5-bromo-2-fluoropyridine shows regional differentiation: “Asia-Pacific dominates production, North America and Europe lead in high-purity pharmaceutical and specialty applications, and Latin America and Middle East & Africa are emerging growth regions.”
The global 5-bromo-2-fluoropyridine market is the subject of comprehensive industry research, with reports covering market drivers, challenges, supply/demand dynamics, regional overviews (Europe, Asia, North America, etc.), and detailed market predictions. The broader fluoropyridines market, of which 5-bromo-2-fluoropyridine is a key subsegment, was valued at approximately USD 83-94 million in 2025 and is projected to grow at a CAGR of 6.8-7.0% through 2032.
Asia-Pacific, particularly China, is the world’s largest producer and fastest-growing region for halogenated pyridine intermediates. Chinese manufacturers, including XinChem, offer competitive pricing at scales ranging from research quantities to industrial batches, serving both domestic demand for pharmaceutical and agrochemical intermediates and exports to global markets. The compound is available at competitive prices, with R&D quantities available from approximately USD 20-50 and bulk industrial pricing available upon request.
North America (United States and Canada) and Europe (Germany, Switzerland, United Kingdom, France) together account for the largest share of high-purity pharmaceutical and specialty consumption (≥99%), driven by the highest concentration of pharmaceutical R&D, agrochemical innovation, and advanced material research. Customer requirements in these regions are stringent: purity ≥98%, full traceability, compliance with REACH and TSCA regulations, and comprehensive impurity documentation.
Japan and South Korea demand ultra-high-purity grades for advanced pharmaceutical development and high-performance liquid crystal applications.
Regulatory and Environmental Considerations
5-Bromo-2-fluoropyridine (CAS 766-11-0) is subject to regulatory oversight in major economies, particularly when intended for pharmaceutical, agrochemical, and material applications. The compound has an MDL number MFCD01863742. Storage conditions: store in a tightly sealed container at room temperature (below 15°C in a cool, dry place), protected from moisture and incompatible materials. The compound is classified as a combustible liquid.
In the European Union, 5-bromo-2-fluoropyridine is registered under REACH; importers and manufacturers must provide Safety Data Sheets (SDS). In the United States, the compound is regulated under TSCA as an existing chemical substance; for pharmaceutical API use, adherence to cGMP guidelines (21 CFR Parts 210/211) is required. In China, the compound is listed in the Inventory of Existing Chemical Substances (IECSC) and requires safety production licenses for manufacturing facilities.
Environmentally, halogenated organic compounds require responsible handling and disposal. Manufacturing processes generate solvent-containing waste streams requiring proper treatment and disposal in accordance with environmental regulations.
Future Outlook
The market outlook for 5-bromo-2-fluoropyridine is tied to three core drivers: (1) sustained growth in global demand for halogenated heterocyclic pharmaceutical intermediates, driven by the increasing role of fluorine and bromine in drug design (particularly in antiviral, anticancer, and immunotherapy applications); (2) rising demand for high-performance agrochemicals to ensure food security, where halogenated pyridines serve as key building blocks for next-generation crop protection agents; and (3) expanding applications in liquid crystals, OLEDs, and organic electronic materials for advanced display technologies. The global fluoropyridines market is projected to grow at a CAGR of 6.8-7.0% through 2032.
Challenges include: raw material cost volatility for halogenating agents and pyridine precursors, competition from alternative halogenated pyridine regioisomers, and potential regulatory restrictions on certain halogenated compounds. Enterprises should focus on securing high-purity (≥99%) production capabilities, maintaining rigorous impurity documentation for global regulatory filings, ensuring compliance with REACH and TSCA requirements, and building long-term supply partnerships with pharmaceutical manufacturers, agrochemical companies, and advanced material producers.
Shanghai XinChem Co., Ltd. (XinChem)
As a world-leading supplier of halogenated heterocyclic intermediates, pharmaceutical building blocks, and specialty chemicals, Shanghai XinChem Co., Ltd. (XinChem) has always focused on the innovative needs of the pharmaceutical, agrochemical, and material science industries. Relying on core advantages in organic synthesis, halogenation chemistry, cross-coupling technology, quality control, and global logistics, we provide high-quality 5-Bromo-2-fluoropyridine (CAS 766-11-0) to global customers. Our product is manufactured under strict quality management, achieving consistent specifications for pharmaceutical, agrochemical, and research grades. Fully compliant with international quality standards, it is an ideal halogenated pyridine building block for pharmaceutical API synthesis, agrochemical development, liquid crystal production, and advanced material applications.
1. Technical Advantages
High Purity & Consistency: Our 5-bromo-2-fluoropyridine achieves purity levels of ≥98-99% (verified by GC analysis), supplied as a colorless to light yellow clear liquid, molecular weight 175.99 g/mol, boiling point 63°C at 15 mmHg.
Low Impurity Profile: Strict control of residual solvents, heavy metals, and related substances ensures high performance for pharmaceutical, agrochemical, and material applications.
Multiple Grades Available: We offer research grade (for laboratory and R&D applications), industrial grade (for agrochemical and material synthesis), and high-purity grade (for pharmaceutical and advanced applications).
Batch-to-Batch Uniformity: Rigorous analytical testing (GC, GC-MS, density, refractive index) guarantees consistent quality and reproducible performance across all production lots.
2. Product Advantages
Versatile Halogenated Pyridine Building Block: Directly used in pharmaceutical synthesis (neuropeptide Y receptor Y5 inhibitors, SARS-CoV-2 protease inhibitors, IDO1 inhibitors, vesicular acetylcholine transport ligands, benzo[3,2-d]furanopyrimidin-2-one derivatives), agrochemical production (herbicides, insecticides, fungicides), liquid crystals and OLED materials, and cross-coupling reactions (Suzuki–Miyaura, Buchwald–Hartwig, SNAr).
Orthogonal Reactivity: The 2-fluoro substituent enables SNAr reactions, while the 5-bromo substituent provides a handle for palladium- or copper-catalyzed cross-couplings, enabling sequential functionalization without intervening purification steps.
Predictable Reactivity: The electron-withdrawing fluorine activates the adjacent bromine for high-fidelity Suzuki-Miyaura cross-coupling at the 5-position.
Flexible Packaging: 1g, 5g, 10g, 25g, 50g, 100g, 500g (R&D); 1kg, 5kg, 10kg, 25kg, 50kg HDPE drums/steel drums (industrial); full custom packaging available.
Reliable Supply Chain: Annual capacity in the multi-ton range, with dedicated warehousing (cool, dry, <15°C, sealed containers) and just-in-time delivery capabilities.
3. Application Fields
- Pharmaceutical Synthesis: Neuropeptide Y receptor Y5 inhibitors, SARS-CoV-2 main protease inhibitors, IDO1 inhibitors for cancer immunotherapy, vesicular acetylcholine transport ligands, and other fluorinated APIs.
- Agrochemical Production: Herbicides, insecticides, fungicides, and crop protection agents.
- Liquid Crystals & Advanced Materials: Liquid crystal formulations for LCD and OLED display technologies.
- Cross-Coupling Chemistry: Suzuki–Miyaura, Buchwald–Hartwig, and SNAr reactions for constructing complex fluorinated heterocyclic compounds.
- Organic Synthesis: Building block for functionalized pyridine derivatives and advanced intermediates.
4. Service Support
Our technical team provides cross-coupling reaction guidance, application optimization recommendations, impurity profiling, and regulatory documentation (Certificate of Analysis, Technical Data Sheet, Safety Data Sheet, REACH compliance, TSCA certification). We offer custom packaging and just-in-time delivery.
5. Why Choose XinChem
- Professionalism: 20+ years in the pharmaceutical, agrochemical, and halogenated heterocyclic industries.
- Flexibility: Tailored to customer purity specifications, grade requirements, packaging sizes, and regulatory documentation needs.
- Cost-effectiveness: High quality at competitive industrial pricing.
Contact us now to start cooperation!
Website: www.xinchem.com
Email: sales1@xinchem.com
WhatsApp: +86 18049800532
Post time: Jul-22-2026