2,5-Dimethoxypyridine (CAS: 867267-24-1) is a heterocyclic organic compound with the molecular formula C₇H₉NO₂ and a molecular weight of 139.15 g/mol. It appears as a colorless to light yellow liquid with a characteristic odor, and is widely used across pharmaceutical, agrochemical, and materials science research. The structure features a pyridine ring with two methoxy groups (-OCH₃) at the 2 and 5 positions, which serve as electron-donating substituents that influence the reactivity of the pyridine ring while providing excellent solubility in organic solvents and sites for further chemical modification. This unique substitution pattern is essential for the regioselective synthesis of 4,7-dimethoxy 5- and 6-azaindoles.
As a versatile intermediate, 2,5-Dimethoxypyridine is widely used in the synthesis of pharmaceuticals, agrochemicals, and functional materials. It serves as a reactant in the regioselective preparation of trioxopyrrolopyridines and functionalized azaindoles, and is a key precursor for the synthesis of 6-azaindole — an important scaffold in kinase inhibitor drug discovery. Market demand is closely linked to the global expansion of pharmaceutical R&D, the growing need for heterocyclic building blocks in drug discovery, and the increasing adoption of pyridine derivatives in agrochemical and materials science applications. Based on its chemical characteristics and industrial chain position, this article systematically analyzes international market dynamics of 2,5-Dimethoxypyridine, focusing on core application scenarios, competitive landscape, regional differences, regulatory trends, and future outlook, providing strategic references for industry participants.
Core Application Fields and Demand
Market demand for 2,5-Dimethoxypyridine is concentrated in three major sectors: pharmaceutical synthesis and API development (≈50-60% of global consumption), agrochemical synthesis (≈20-25%), and materials science and organic electronics (≈10-15%), with additional demand from specialty chemical manufacturers and research laboratories (≈5-10%).
In the pharmaceutical synthesis and API development sector, 2,5-Dimethoxypyridine serves as a key building block for the preparation of a wide range of biologically active molecules. It is used as a reactant in the regioselective preparation of trioxopyrrolopyridines and functionalized azaindoles. The compound is an intermediate in the synthesis of acetonitrile derivatives and 6-azaindole, which is a critical scaffold for kinase inhibitors targeting various oncology pathways. The methoxy groups can be further modified for additional chemical transformations, enabling the construction of diverse compound libraries for drug discovery campaigns. The global market for pharmaceutical intermediates continues to expand, driven by the increasing complexity of drug molecules and the growing demand for specialized heterocyclic building blocks.
In the agrochemical synthesis sector, 2,5-Dimethoxypyridine is utilized in the formulation of crop protection agents. Derivatives such as 4-amino-3-(difluoromethyl)-2,5-dimethoxypyridine are being investigated as candidates for novel herbicides or plant growth regulators due to their ability to inhibit specific enzymes involved in plant growth regulation. Other derivatives, such as 4-bromo-3-(difluoromethyl)-2,5-dimethoxypyridine, serve as important intermediates in modern agrochemical synthesis. The global agrochemical market continues to grow, driven by the need to ensure food security in the face of rising global population, and pyridine-based intermediates are playing an increasingly important role in this segment.
In the materials science and organic electronics sector, 2,5-Dimethoxypyridine is used as a building block for the synthesis of functional materials, including components for organic light-emitting diodes (OLEDs). The specific properties of the dimethoxypyridine scaffold, such as its electron-rich character and thermal stability, make it suitable for applications in optoelectronic devices. Pyridine-incorporated compounds have been investigated as blue emitters in OLEDs, and the 2,5-dimethoxy substitution pattern provides a platform for tuning electronic properties.
Major Market Participants
The global supply system for 2,5-Dimethoxypyridine follows a pattern of specialized heterocyclic intermediate manufacturers, with production concentrated in China, Europe, India, and North America. The compound is generally supplied as a clear to light yellow liquid with purity ranging from 95% to ≥99% (verified by GC analysis). Major international suppliers and manufacturers include MedChemExpress (USA), TargetMol (USA), Nordmann (Germany), Biozol (Germany), CymitQuimica (Spain), AK Scientific (USA), BOC Sciences (USA), and BenchChem (USA). High-purity grades (99.98%) are available for research applications. Chinese manufacturers, including XinChem, Shanghai Yuanye Bio-Technology, Bidepharm, and Aladdin, offer competitive pricing for both R&D and industrial scales.
Shanghai XinChem Co., Ltd. (XinChem) has established a reliable, quality-controlled supply chain for high-purity 2,5-Dimethoxypyridine (CAS 867267-24-1). Our product is manufactured under strict quality management, achieving consistent purity (≥98-99% by GC) with low residual solvents and low heavy metals, fully complying with pharmaceutical, agrochemical, and research intermediate standards. It is an ideal heterocyclic building block for pharmaceutical API synthesis, agrochemical development, and functional material research.
Regional Market Dynamics
Global demand for 2,5-Dimethoxypyridine shows regional differentiation: “Asia-Pacific dominates production, North America and Europe lead in high-purity R&D and pharmaceutical applications, and Latin America & Middle East/Africa follow as emerging growth markets.” The compound is the subject of comprehensive market research reports covering global and regional markets (Europe, Asia, North America, etc.), including producers, suppliers, prices, and end-use sectors.
Asia-Pacific, particularly China, is the world’s largest producer and fastest-growing region for heterocyclic intermediates. Chinese manufacturers, including XinChem, offer competitive pricing at scales ranging from research quantities to industrial batches, serving both domestic demand for pharmaceutical and agrochemical intermediates and exports to Southeast Asia, Europe, and North America.
North America (United States and Canada) and Europe (Germany, United Kingdom, Switzerland, France) together account for the largest share of high-purity R&D consumption (≥99%), driven by the highest concentration of pharmaceutical drug discovery programs and agrochemical innovation. Customer requirements in these regions are stringent: purity ≥98%, full traceability, ICH Q3D compliance for heavy metals, full impurity profiling, and cGMP documentation for pharmaceutical use.
Regulatory and Environmental Considerations
2,5-Dimethoxypyridine (CAS 867267-24-1) is classified as a skin irritant (H315). Recommended storage conditions: store at room temperature for up to 3 years in powder form, or at -80°C in solution for up to 2 years. In solvent at -20°C, the compound is stable for up to 1 year. The compound should be stored in tightly sealed containers in a dry, light-protected environment, away from ignition sources and oxidizing agents. Personal protective equipment (PPE) — including chemical-resistant gloves, safety glasses, and respiratory protection — is recommended during handling.
In the European Union, the compound is subject to REACH regulations; importers and manufacturers must provide Safety Data Sheets (SDS). In the United States, it is regulated under TSCA as a research chemical; for pharmaceutical API use, adherence to cGMP guidelines (21 CFR Parts 210/211) is required. In China, the compound is listed in the Inventory of Existing Chemical Substances (IECSC) and requires safety production licenses for manufacturing facilities. Environmentally, as with all organic compounds, responsible handling and disposal are essential; manufacturing generates solvent-containing waste streams requiring proper treatment.
Future Outlook
The market outlook for 2,5-Dimethoxypyridine is tied to three core drivers: (1) sustained growth in global demand for heterocyclic building blocks for pharmaceutical synthesis, driven by the expanding portfolio of kinase inhibitors and other targeted therapeutics; (2) rising demand for high-performance agrochemicals to ensure food security; and (3) development of organic electronics and functional materials, including OLEDs, requiring specialized pyridine-based intermediates. The compound is widely available from multiple international suppliers, and Chinese manufacturers continue to expand production capacity to meet growing global demand. The compound’s unique substitution pattern and its role as a precursor for 6-azaindole and other pharmaceutically relevant scaffolds position it for sustained growth in the coming years.
Shanghai XinChem Co., Ltd. (XinChem)
As a world-leading supplier of heterocyclic intermediates, pharmaceutical building blocks, and specialty chemicals, Shanghai XinChem Co., Ltd. (XinChem) has always focused on the innovative needs of the pharmaceutical, agrochemical, and materials science industries. Relying on core advantages in organic synthesis, quality control, and global logistics, we provide high-quality 2,5-Dimethoxypyridine (CAS 867267-24-1) to global customers. Our product is manufactured under strict quality management, achieving consistent specifications for pharmaceutical, agrochemical, and research grades. Fully compliant with international quality standards, it is an ideal heterocyclic building block for pharmaceutical API synthesis, agrochemical development, and functional material research.
1. Technical Advantages
High Purity & Consistency: Our 2,5-Dimethoxypyridine achieves purity levels of ≥98-99% (verified by GC analysis), supplied as a clear to light yellow liquid, molecular weight 139.15 g/mol, MDL MFCD12546620, LogP 1.1.
Low Impurity Profile: Strict control of residual solvents (<0.5% total), heavy metals (≤10 ppm, ICH Q3D compliant), and related substances by GC-FID.
Pharmaceutical-Grade Quality: The compound is tested for full ICH Q3C (residual solvents) and ICH Q3D (heavy metals), with full traceability to primary analytical standards. DMF support is available for pharmaceutical customers.
Batch-to-Batch Uniformity: Rigorous analytical testing (GC, NMR, LC-MS, heavy metals by ICP-MS, residual solvents by GC-headspace) guarantees consistent quality and reproducible yields across all production lots.
2. Product Advantages
Versatile Heterocyclic Building Block: Directly used in the synthesis of pharmaceutical APIs (kinase inhibitors, 6-azaindole, functionalized azaindoles, trioxopyrrolopyridines), agrochemical intermediates (herbicides, plant growth regulators), and functional materials (OLED components).
Two Reactive Methoxy Groups: Provide excellent solubility in organic solvents and serve as sites for further chemical modification, including nucleophilic substitution and demethylation reactions.
High Purity Grades: Available in 98% and 99% purity, with ultra-high purity (99.98%) for research applications.
Flexible Packaging Options: 1g, 5g, 10g, 25g, 50g, 100g (glass vials for R&D); 500g, 1kg (HDPE containers for pilot batches); 5kg, 10kg, 25kg (fiber drums for industrial batches). Full custom packaging available.
Reliable Supply Chain: Annual capacity in the multi-ton range, with dedicated temperature-controlled warehousing (room temperature, dry, light-protected, sealed containers) and just-in-time delivery capabilities.
3. Application Fields
- Pharmaceutical Intermediates: Synthesis of kinase inhibitors, functionalized azaindoles, trioxopyrrolopyridines, 6-azaindole, Perampanel impurity reference standard, and other biologically active molecules.
- Agrochemical Intermediates: Synthesis of herbicides, plant growth regulators, and crop protection agents.
- Materials Science & Organic Electronics: Development of functional materials, including components for organic light-emitting diodes (OLEDs) and optoelectronic devices.
- Regioselective Synthesis: Reactant for the regioselective preparation of trioxopyrrolopyridines and functionalized azaindoles.
- Organic Synthesis: Building block for acetonitrile derivatives and other specialty chemicals.
4. Service Support
Our technical team provides full impurity profiling (GC purity, residual solvents by GC-headspace, heavy metals by ICP-MS, LC-MS identity confirmation), custom purification to any desired specification, and complete regulatory documentation (Certificate of Analysis, Technical Data Sheet, Safety Data Sheet, REACH compliance, TSCA certification, DMF support for pharmaceutical customers). We also offer custom synthesis of pyridine derivatives and just-in-time delivery.
5. Why Choose XinChem
- Professionalism: 20+ years in the pharmaceutical, agrochemical, and chemical industries.
- Flexibility: Tailored to customer purity specifications, packaging sizes, and regulatory documentation requirements.
- Cost-effectiveness: High quality at competitive industrial pricing.
Contact us now to start cooperation!
Website: www.xinchem.com
Email: sales1@xinchem.com
WhatsApp: +86 18049800532
Post time: Jul-05-2026