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4-Morpholinoaniline (IUPAC name: 4-morpholin-4-ylaniline, also known as N-(4-Aminophenyl)morpholine, 4-(4-Morpholinyl)benzenamine, CAS: 2524-67-6) is a para-substituted aniline derivative bearing a morpholine ring directly attached to the 4-position of the phenylamine core. Its molecular formula is C₁₀H₁₄N₂O, with a molecular weight of 178.23 g/mol, and it presents as a white to light-yellow to brown crystalline powder with a melting point of 130–135°C. The compound is soluble in most organic solvents (alcohols, ethers, ketones, chloroform, ethyl acetate) and slightly soluble in water..

The structure of 4-Morpholinoaniline combines the electron‑donating effect of the primary aromatic amine (-NH₂) at the para position with the hydrogen‑bond accepting capability of the oxygen atom in the morpholine ring. This specific substitution pattern imparts a distinct electronic and steric profile that cannot be replicated by simple analogs such as 4‑piperidinoaniline (which lacks the oxygen atom’s hydrogen‑bonding capability) or 3‑fluoro‑4‑morpholinoaniline (which has altered electron density and lipophilicity due to fluorine substitution). The para-substituted aniline scaffold enables diverse functionalization pathways: the primary amine can undergo amide coupling, Schiff base formation, diazotization, reductive amination, and heterocyclic annulation, while the morpholine ring improves aqueous solubility and bioavailability of downstream drug molecules. This unique combination of reactive functional groups makes 4-Morpholinoaniline an essential building block across multiple high‑value industrial sectors.

Core Application Fields and Market Demand

Market demand for 4-Morpholinoaniline is rapidly expanding and is strongly concentrated in four major end‑use sectors: pharmaceutical R&D (≈45-50% of total consumption), polymer science & advanced materials (≈20-25%), organic synthesis & fine chemicals (≈15-20%), and dye intermediates & analytical reagents (≈10-15%).

The global 4-Morpholinoaniline market has been the subject of comprehensive industry research, with reports covering market drivers, challenges, supply/demand dynamics, regional overviews (Europe, Asia, North America, etc.), and detailed market predictions up to 2029. The compound is manufactured using large‑scale hydrogenation processes, typically by reacting 4‑nitroaniline with morpholine followed by catalytic hydrogenation of the nitro group to an amino group, with the reaction generally carried out in ethanol at room temperature for several hours to ensure complete reduction.

1. Pharmaceutical Development — The Dominant Demand Driver (≈45-50% of total consumption). 4-Morpholinoaniline serves as a key intermediate in the synthesis of various pharmaceutical agents, particularly in the development of anti‑cancer drugs and central nervous system (CNS) active agents. The compound is a versatile fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification, providing a structural basis and research tool for the design and screening of novel drug candidates.

Momelotinib API Synthesis (JAK1/2 & ACVR1 Inhibitor). The most prominent documented application of 4-Morpholinoaniline in pharmaceutical synthesis is as a direct starting material for the anticancer drug momelotinib (MMB), a small‑molecule inhibitor of Janus kinase (JAK)1/2 and activin A receptor type 1 (ACVR1) in clinical development for the treatment of myeloproliferative neoplasms (MPNs). An improved route for the synthesis of momelotinib has been developed, wherein a nucleophilic addition reaction between the starting material, 4‑morpholinoaniline, and cyanamide gives the 1‑(4‑morpholinophenyl)guanidine intermediate, which is then condensed at elevated temperature in alcoholic alkali with an enaminone intermediate to yield the target drug.
Kinase Inhibitors and Anticancer Agents. 4-Morpholinoaniline is used as a building block for synthesising various bioactive molecules with anticancer properties. The morpholine ring significantly improves the pharmacokinetic properties of drug candidates by enhancing aqueous solubility and bioavailability, while the primary amine serves as an anchor for coupling with carboxylic acids, halides, and other electrophiles in multi‑step API synthesis.
CNS Active Agents. The compound is specifically listed as a morpholine derivative used in the preparation of central nervous system (CNS) active agents, including compounds with potential applications in psychiatric and neurological disorders.
Antifungal and Antimicrobial Agents. Patents and research publications have described the use of triazole derivatives synthesized from 4‑morpholinoaniline scaffolds with antifungal activity. Additionally, compounds derived from 4‑morpholinoaniline exhibit potent antibacterial properties, making them valuable leads for developing novel antibiotics.
Fragment‑Based Drug Discovery (FBDD). As a fragment molecule, 4-Morpholinoaniline provides an excellent starting point for hit‑to‑lead optimization campaigns targeting GPCRs, kinases, and other therapeutically relevant protein families.

2. Polymer Science & Advanced Materials — High‑Growth Segment (≈20-25% of total consumption). 4-Morpholinoaniline is widely used in the formulation of specialty polymers, contributing to materials with improved mechanical and thermal properties.

Polymer Modification. By introducing the morpholinoaniline structure, the polarity and solubility of polymeric materials can be significantly improved, enhancing their potential in high‑performance coatings, adhesives, and other applications.
Thermoplastics & Flame Retardants. This compound serves as an intermediate in the synthesis of flame retardants or UV absorbers used to enhance the weather resistance and flame retardancy of plastics. For example, adding relevant derivatives to flame‑retardant PA66 plastic can significantly improve the flame retardant level of the material, making it safer for applications in electronics and automotive components.
Epoxy Resin Curing Agents. 4-Morpholinoaniline can be used as a modified amine curing agent. By introducing morpholine groups, the compatibility between curing agents and epoxy resins can be improved, toxicity can be reduced, and the mechanical properties of the cured material can be enhanced. 4-Morpholinoaniline is also used as a curing agent for epoxy resins in the production of high‑performance composites for automotive and aerospace industries.

3. Organic Synthesis & Fine Chemicals (≈15-20% of total consumption). In organic chemistry, 4-Morpholinoaniline serves as a versatile platform for the preparation of complex molecules, allowing researchers to create diverse compounds with tailored properties.

Ligand Synthesis. The compound is used in the preparation of Schiff base ligands and other coordination compounds for catalysis and metal‑organic framework (MOF) applications.
Heterocyclic Library Construction. Its rigid architecture and dual reactive sites make it a valuable building block for generating libraries of heterocyclic compounds for drug discovery campaigns.

4. Dye Intermediates & Analytical Reagents (≈10-15% of total consumption). 4-Morpholinoaniline is utilized as a dye intermediate in the production of dyes and pigments, where it undergoes chemical reactions that lead to the formation of coloured compounds. The compound is also one of the primary aromatic amines used in the colour developing process in photography.

Analytical Chemistry. 4-Morpholinoaniline acts as a reagent in analytical methods, aiding in the detection and quantification of various substances, which is crucial for quality control in manufacturing.
Biosensors. It finds applications in the development of biosensors, enhancing the sensitivity and specificity of detection methods used in medical diagnostics.

Global Market Landscape & Key Players

The global 4-Morpholinoaniline market is served by a network of specialized fine‑chemical and pharmaceutical‑intermediate manufacturers and distributors, with key players including TCI Chemicals (purity >98.0% GC), Chem‑Impex (≥99% GC), Thermo Fisher Scientific (Alfa Aesar), BOC Sciences, BenchChem, AK Scientific, MolCore, TargetMol, J&K Scientific, Aladdin, and Fisher Scientific. The compound is available in R&D and industrial quantities, from 1 g glass bottles to 25 kg fiber drums.

The compound is typically supplied with purity ranging from 98% to ≥99% (GC/HPLC). Custom packaging options are available for pharmaceutical and industrial campaigns. Major international distributors offer the compound with full regulatory documentation, including Safety Data Sheets (SDS), Certificates of Analysis (COA), and for some suppliers, REACH and TSCA compliance documentation. Global aniline derivatives market, in which 4-Morpholinoaniline is a specialised sub‑segment, was valued at approximately USD 210 billion in 2024 and is expected to grow to USD 330 billion by 2031, at a CAGR of 6.00%. The compound is also part of the broader pyridine derivatives supply chain (HS code 2934.99‑000), which includes morpholine and piperazine derivatives. Leading international distributors report significant supply capacities, with one supplier noting an ability to supply 5,000 kg per month.

Storage, Stability & Regulatory Considerations

4-Morpholinoaniline (CAS 2524-67-6) should be stored at room temperature (recommended in a cool and dark place, <15°C) in a tightly sealed container under an inert gas (nitrogen or argon) to prevent air‑sensitive degradation. The powder is stable for up to three years when stored at –20°C and for up to two years at 2‑8°C; solutions in DMSO are stable for up to one year at –80°C. The compound is classified with hazard statements H302+H312+H332 (Harmful if swallowed, in contact with skin or if inhaled) and H315+H319 (Causes skin and eye irritation). Transport information: UN 2811 (toxic solid), Class 6.1, Packing Group III, with a hazmat fee applicable to certain package sizes and shipment methods. In the European Union, the compound is subject to REACH regulations; importers and manufacturers must provide Safety Data Sheets (SDS). In the United States, it is regulated under TSCA as a research chemical; for use in pharmaceutical API synthesis, adherence to cGMP guidelines (21 CFR Parts 210/211) is required. In China, the compound is listed in the Inventory of Existing Chemical Substances (IECSC), with HS Tariff Code 2934.99.9001.

Future Outlook

The market outlook for 4-Morpholinoaniline is tied to four core drivers: (1) the continued expansion of the global pharmaceutical industry, particularly the development of kinase inhibitors and CNS‑active agents; (2) the rapid growth of specialty polymer applications in automotive, aerospace, and electronics sectors, where the compound‘s ability to improve mechanical and thermal properties is increasingly valued; (3) the expansion of Asian CRO/CDMO sectors supplying intermediates to global pharmaceutical companies; and (4) the increasing adoption of fragment‑based drug discovery (FBDD) strategies in pharmaceutical R&D, where privileged heterocyclic fragments like 4‑morpholinoaniline serve as ideal starting points for hit‑to‑lead optimization.

Companies that invest in high‑purity (≥99%) production capabilities, maintain rigorous impurity documentation for global regulatory filings, and build long‑term supply partnerships with pharmaceutical API manufacturers, polymer formulators, and research institutions will be best positioned to capture value in this growing market.

Shanghai XinChem Co., Ltd. (XinChem)

As a world‑leading supplier of pharmaceutical intermediates, heterocyclic building blocks, and fine chemicals, Shanghai XinChem Co., Ltd. (XinChem) has always focused on the innovative needs of the API manufacturing, specialty polymer, and dye intermediate industries. Relying on core advantages in multi‑step hydrogenation, purification, and quality assurance, we provide high‑quality 4-Morpholinoaniline (CAS 2524-67-6) to global customers.

1. Technical Advantages

High Purity & Consistency: Our product achieves purity ≥98‑99% (GC/HPLC), white to off‑white to light yellow crystalline powder, molecular weight 178.23 g/mol, melting point 130‑135°C, MDL MFCD00006169, and moisture <0.5% (KF titration).
Low Impurity Profile: Strict control of residual solvents (<0.5% total), heavy metals (≤10 ppm, ICH Q3D compliant), and related substances by HPLC‑UV ensures high synthetic performance for API, polymer, and fine chemical manufacturing.
Pharmaceutical‑Grade Quality: The compound is tested for full ICH Q3C (residual solvents), ICH Q3D (heavy metals), and USP residual solvents, providing full traceability to primary analytical standards.
Batch‑to‑Batch Uniformity: Rigorous analytical testing (GC, HPLC, NMR, LC‑MS, heavy metals by ICP‑MS, residual solvents by GC‑headspace, Karl Fischer titration) guarantees consistent quality and reproducible yields across all production lots.

2. Product Advantages

Versatile Morpholinoaniline Scaffold: Directly used as a key intermediate for momelotinib API (JAK1/2 inhibitor for myeloproliferative neoplasms), CNS active agents, kinase inhibitors, anticancer APIs, and heterocyclic drug candidates.
Polymer & Advanced Material Applications: Building block for specialty polymers (polyimides, high‑performance thermoplastics), epoxy resin curing agents, UV absorbers, and flame‑retardant additives.
Dye Intermediate & Analytical Reagent: Used for dye and pigment production, photographic colour developing processes, and as a reagent for analytical method development.
Flexible Packaging Options: 1 g, 5 g, 10 g, 25 g, 50 g, 100 g, 500 g, 1 kg glass bottles/HDPE containers (R&D/pilot); 5 kg, 10 kg, 25 kg, 50 kg fibre drums (industrial). Full custom packaging available for pharmaceutical, polymer, and specialty chemical campaigns.
Reliable Supply Chain: Annual capacity in the multi‑metric‑ton range, with dedicated temperature‑controlled warehousing (room temperature, under inert gas, dry, light‑protected, sealed containers) and just‑in‑time delivery capabilities.

3. Application Fields

Pharmaceutical Intermediates: Key building block for momelotinib API (JAK1/2 & ACVR1 inhibitor), kinase inhibitors (momelotinib), CNS active agents, anticancer APIs, antifungal and antimicrobial drug candidates.
Fragment‑Based Drug Discovery (FBDD): Privileged heterocyclic fragment for molecular linking, expansion, and modification in hit‑to‑lead optimization campaigns targeting kinases, GPCRs, and other protein classes.
Polymer & Advanced Materials: Specialty polymer synthesis (polyimides, high‑performance thermoplastics), epoxy resin curing agents, UV absorbers, flame‑retardant additives for electronics and automotive components.
Dye Intermediates: Production of dyes, pigments, photographic colour developers, and colour developing agents.
Analytical Chemistry: Reagent for analytical method development, biosensor fabrication, and quality control in manufacturing processes.

4. Service Support
Our technical team provides full impurity profiling (GC purity, HPLC‑UV related substances, residual solvents by GC‑headspace, heavy metals by ICP‑MS, LC‑MS identity confirmation), custom purification to any desired specification, and complete regulatory documentation (Certificate of Analysis, Technical Data Sheet, Safety Data Sheet, REACH compliance, TSCA certification, DMF support for pharmaceutical customers). We also offer custom synthesis of morpholine derivatives, cold‑chain logistics, and just‑in‑time delivery.

5. Why Choose XinChem

Professionalism: 20 + years in the pharmaceutical intermediate, heterocyclic chemistry, and fine chemical industries.
Flexibility: Tailored to customer purity specifications, packaging sizes, and regulatory documentation requirements.
Cost‑effectiveness: High purity at competitive industrial pricing.

Post time: Jun-07-2026

A Versatile Heterocyclic Building Block for Pharmaceuticals, Material Science & Dye Intermediates: 4-Morpholinoaniline (CAS 2524-67-6)