2,4-Difluorobenzylamine (CAS# 72235-52-0), also known as (2,4-difluorophenyl)methanamine or 2,4-DFBA, is a fluorinated aromatic primary amine with the molecular formula C₇H₇F₂N and a molecular weight of 143.13 g/mol. Its molecular structure consists of a benzylamine scaffold bearing two fluorine atoms at the 2- and 4-positions of the benzene ring, combined with a reactive primary amine group (–CH₂NH₂). This specific difluorination pattern imparts unique physicochemical properties that are highly valued in the synthesis of complex drug molecules, enhancing metabolic stability, lipophilicity, and bioavailability of drug candidates. The carbon–fluorine bond is the strongest single bond to carbon, and this exceptional stability underpins the “fluorine scan” strategy used in medicinal chemistry to optimize drug candidates.
The compound typically appears as a colorless to pale yellow transparent liquid with a characteristic amine odor, a boiling point of 82–84°C at 15 mmHg, a density of 1.204 g/mL at 25°C, and a refractive index of n20/D 1.49. It is soluble in organic solvents such as ethanol, methanol, and dichloromethane, but insoluble in water. The compound is air-sensitive and should be stored under inert gas (nitrogen or argon) at 2–8°C. As a high-value fluorinated organic amine, 2,4-difluorobenzylamine serves as a critical building block for active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials. Its production relies on specialized fluorination chemistry, and market demand is closely tied to the global trends of innovative drug R&D and generic drug volume expansion. Based on its chemical characteristics and industrial chain position, this article systematically analyzes the international market dynamics of 2,4-difluorobenzylamine, focusing on core application scenarios, competitive landscape, regional differences, regulatory trends, and future outlook, providing strategic references for industry participants.
Core Application Fields and Demand
Market demand for 2,4-difluorobenzylamine (CAS# 72235-52-0) is concentrated in four major areas: pharmaceutical synthesis (approximately 65–70% of global consumption), agrochemical development (approximately 15–20%), fine chemical synthesis and materials science (approximately 10–15%), with the remainder in analytical chemistry and research applications. The unique 2,4-difluorophenyl moiety combined with the reactive amine group serves as the core advantage driving demand growth.
In pharmaceutical synthesis, 2,4-difluorobenzylamine is a cornerstone intermediate in the synthesis of several blockbuster drugs, most notably the HIV integrase inhibitor Dolutegravir (Tivicay®). The 2,4-difluorobenzyl moiety is strategically incorporated to enhance the drug’s binding affinity to the target enzyme and improve its pharmacokinetic profile. The synthesis of Dolutegravir involves a key step where 2,4-difluorobenzylamine reacts with a carboxylic acid derivative to form an amide bond, a critical transformation in the drug’s synthetic route. Beyond HIV therapeutics, the compound is utilized in the synthesis of antiviral drugs including HCV NS3/4A inhibitors, anticancer agents such as kinase inhibitors and PARP inhibitors, and central nervous system (CNS) drugs. The difluorobenzylamine moiety is found in molecules such as fluvoxamine (an SSRI antidepressant) and voriconazole (an antifungal), as well as various investigational compounds. The compound is also a key precursor for peptide modification and PROTAC (proteolysis-targeting chimera) linkers, enabling the development of next-generation targeted therapeutics.
In agrochemical development, 2,4-difluorobenzylamine serves as a crucial fluorinated building block in the design and synthesis of modern crop protection agents. It is used in the synthesis of pyrazole carboxamide fungicides, including fluopyram analogs, as well as modern fluorinated herbicides and insecticides. Fluorine substitution improves environmental stability and target selectivity, making these agrochemicals more effective and potentially more environmentally friendly.
In fine chemical synthesis and materials science, the compound is employed as an intermediate for manufacturing specialty amines, amides, Schiff bases, and heterocyclic compounds (e.g., benzimidazoles, quinazolines) with enhanced bioactivity. It is also used in the production of fluorinated polymers, liquid crystal displays (LCDs), and functional coatings requiring unique electronic or optical properties.
Major Market Participants
The global supply system for 2,4-difluorobenzylamine (CAS# 72235-52-0) features a pattern of “specialized fluorinated intermediate manufacturers, multinational research chemical distributors, and Chinese producers serving distinct market segments.” The global market for this compound is estimated to be in the range of USD 5–10 million, with a projected CAGR of 3–5% through 2029, driven by the continued growth of antiviral drug production and agrochemical development.
In the global research and high-purity segment, key international suppliers include Thermo Fisher Scientific (Acros Organics), offering the compound at ≥97.5% purity (GC) with refractive index specifications of 1.4900 to 1.4930; Tokyo Chemical Industry (TCI), providing >98.0% (GC) purity under product code D1996; Santa Cruz Biotechnology, supplying the compound for research applications with hazard shipping surcharges; and Aladdin Scientific, offering the compound at 98% purity. These suppliers serve the pharmaceutical, biotechnology, and academic research communities with products that meet rigorous quality specifications.
In the industrial and large-scale production segment, Chinese manufacturers have emerged as dominant players in the global supply chain. XinChem is a leading manufacturer and supplier of high-purity 2,4-difluorobenzylamine from China, offering the compound at ≥99.0% (Pharmaceutical Grade) and ≥98.0% (Technical Grade). XinChem leverages deep fluorination chemistry expertise, with ISO9001-certified quality and GMP-aligned manufacturing, supporting custom synthesis of fluorinated amines and derivatives. The company serves global pharmaceutical, biotech, and agrochemical CDMOs with bulk and wholesale supply. Other Chinese suppliers include manufacturers concentrated in major chemical manufacturing regions including Hubei, Shaanxi, Shandong, and Hebei provinces. Chinese suppliers offer the compound at various purity grades (typically 98–99%) and packaging options—from grams to multi-kilogram quantities—serving both domestic and export markets with competitive pricing.
Regional Market Dynamics
The global 2,4-difluorobenzylamine market exhibits distinct regional characteristics, with production concentrated in Asia-Pacific (particularly China) and consumption distributed across North America, Europe, and the Asia-Pacific region, aligned with the pharmaceutical, agrochemical, and fine chemical industries in these regions. The global market report for 2,4-difluorobenzylamine covers comprehensive data on manufacturers, consumers, production situation, supply and demand analysis, price analysis, and import/export situation across Europe, Asia, North America, and other regions, with forecasts extending through 2029.
The Asia-Pacific region is the dominant force in the global 2,4-difluorobenzylamine market, accounting for the largest share of both production and consumption. China serves as the world’s manufacturing hub, with extensive production capacities and integrated supply chains. The rapid growth of the pharmaceutical and agrochemical industries in China, India, and Southeast Asia continues to drive regional demand. Chinese suppliers, including XinChem, offer the compound at various purity grades and packaging options, serving both domestic and export markets. The growing generic drug production of Dolutegravir in India and other Asian countries further stimulates demand for the key intermediate.
North America remains a key market for high-purity and GMP-grade 2,4-difluorobenzylamine, driven by demand from the pharmaceutical and biotechnology sectors. The United States hosts major pharmaceutical companies and contract research organizations that require high-quality intermediates for drug development and manufacturing. Thermo Fisher Scientific and other major distributors serve the North American market with extensive distribution networks. The region relies heavily on imports for the intermediate while focusing on supply chain security and quality assurance.
Europe is characterized by stringent regulatory requirements and a strong focus on quality and sustainability. The region’s pharmaceutical industry demands GMP-compliant intermediates with full documentation. European consumption is driven by finished drug manufacturing, but the region relies heavily on imports from Asia-Pacific for the difluorobenzylamine intermediate. Pharmaceutical companies in Europe seek qualified suppliers that meet cGMP and regulatory filing standards.
Japan represents a specialized market where 2,4-difluorobenzylamine is supplied by TCI Chemicals and other distributors for pharmaceutical research, agrochemical development, and fine chemical applications.
Regulatory and Safety Considerations
As a pharmaceutical intermediate and fluorinated fine chemical, 2,4-difluorobenzylamine (CAS# 72235-52-0) is subject to regulatory oversight in major global economies. Compliance with relevant regulations is essential for market access and trade.
GHS classification and handling: 2,4-Difluorobenzylamine is classified as a corrosive substance. The CLP classification under Regulation (EC) No 1272/2008 includes Skin Corrosion/Irritation Category 1 and Serious Eye Damage/Eye Irritation Category 1. The signal word is ”Danger”. Hazard statements include H314 (Causes severe skin burns and eye damage). Precautionary statements include P280 (Wear eye protection/face protection), P301+P330+P331 (IF SWALLOWED: rinse mouth; do NOT induce vomiting), P305+P351+P338 (IF IN EYES: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; continue rinsing), and P310 (Immediately call a POISON CENTER or doctor/physician). The compound is classified as a combustible liquid. The WGK Germany classification is 3 (high hazard to water).
Storage and stability: 2,4-Difluorobenzylamine should be stored under inert gas (nitrogen or argon) at 2–8°C to prevent oxidative degradation. The compound is air-sensitive and moisture-sensitive, and should be kept in a tightly sealed container in a cool, dry, well-ventilated place, protected from air and moisture. Shelf life is 12 months under recommended storage conditions.
Regulatory compliance: In the European Union, the compound must comply with REACH registration requirements for import and use. The compound has an EINECS number of 276-502-0. Manufacturers and suppliers must provide comprehensive Safety Data Sheets (SDS) and maintain appropriate documentation. In the United States, 2,4-difluorobenzylamine is intended for research and development use only and is not intended for therapeutic, food, cosmetic, or consumer applications unless explicitly stated otherwise. For pharmaceutical intermediate applications, manufacturers must comply with relevant FDA regulations and quality standards.
Transport information: 2,4-Difluorobenzylamine is classified as a dangerous good for international transport under UN 2735 (Amines, liquid, corrosive, n.o.s.), Hazard Class 8, Packing Group III. Proper packaging, labeling, and documentation are required for shipping in compliance with the International Maritime Dangerous Goods Code (IMDG Code) and other transport regulations. The HS code for China export is 29214990.
Future Outlook
The market outlook for 2,4-difluorobenzylamine is positive, supported by several key growth drivers across its major application segments. The global market is projected to maintain steady growth, with a projected CAGR of 3–5% through 2029.
Key growth drivers include:
- Expansion of the HIV therapeutics market: The continued success of Dolutegravir and other integrase inhibitors, combined with expanding access to antiretroviral therapy in developing countries, sustains demand for 2,4-difluorobenzylamine as a key intermediate.
- Growth in targeted therapeutics: The development of new antiviral, anticancer, and CNS drugs incorporating fluorinated pharmacophores continues to drive demand for fluorinated building blocks. The compound’s role as a precursor for PROTAC linkers positions it at the forefront of next-generation drug development.
- Increasing demand for modern agrochemicals: The global trend toward more effective and environmentally friendly crop protection agents supports demand for fluorinated intermediates in pesticide synthesis.
- Expansion of pharmaceutical R&D in Asia: The growth of pharmaceutical R&D and API manufacturing in China and India—driven by increasing investment in generic drug production and innovative drug discovery—supports demand for high-quality pharmaceutical intermediates.
- Advantages of fluorine in drug design: The growing emphasis on metabolic stability and bioavailability in drug design drives demand for regioisomer-specific fluorinated building blocks like 2,4-difluorobenzylamine.
Challenges and considerations:
- Regulatory compliance: Increasingly stringent pharmaceutical and chemical regulations may require ongoing investment in quality systems and documentation.
- Hazardous material handling: The compound’s classification as corrosive (UN 2735) requires specialized handling, packaging, and shipping procedures that may increase costs.
- Isomer differentiation: The specific 2,4-difluoro substitution pattern must be carefully distinguished from other difluorobenzylamine regioisomers, necessitating rigorous quality control and analytical verification.
- Limited scale: As a relatively specialized compound, the market for 2,4-difluorobenzylamine is smaller than that of commodity chemicals.
- Supply chain concentration: The heavy concentration of production in China creates potential supply chain vulnerabilities that may concern international buyers seeking diversification.
To succeed in this evolving market landscape, suppliers must focus on product quality (particularly purity and batch-to-batch consistency), supply chain reliability, regulatory compliance, and responsive customer service. Companies that can offer high-purity products, flexible packaging options, and technical support for pharmaceutical, agrochemical, and fine chemical applications will be well-positioned to capture growing demand.
Shanghai XinChem Co., Ltd. (XinChem)
As a world-leading supplier of organic chemicals and fluorinated building blocks, Shanghai XinChem Co., Ltd. (XinChem) is dedicated to meeting the innovative needs of the pharmaceutical, agrochemical, and fine chemical industries. Leveraging deep fluorination chemistry expertise and advanced manufacturing capabilities, XinChem provides high-quality 2,4-Difluorobenzylamine (CAS# 72235-52-0) to customers worldwide. As a leading difluorobenzylamine supplier and fluorinated intermediate manufacturer, XinChem combines competitive pricing, reliable supply, and exceptional service to establish itself as a preferred partner for pharmaceutical companies, biotech firms, and agrochemical CDMOs seeking this versatile fluorinated building block.
1. Technical Advantages
Advanced Synthesis and Purification Processes
XinChem utilizes state-of-the-art manufacturing facilities and rigorous quality control measures to ensure the purity, consistency, and safety of its 2,4-difluorobenzylamine products. The production process incorporates established synthetic routes—including the chlorination of 2,4-difluorotoluene to form 2,4-difluorobenzyl chloride followed by ammonolysis with ammonia to yield the crude product, which is then purified by distillation—enabling the delivery of products with purity ≥99.0% (Pharmaceutical Grade) and ≥98.0% (Technical Grade). Strict process control ensures minimal moisture content (≤0.3%), low color index (≤50 APHA), and minimal impurities (single maximum impurity ≤0.5%, total impurities ≤1.0%), providing customers with reliable performance in pharmaceutical synthesis, agrochemical development, and fine chemical applications.
Full-Chain Quality Control
The production process strictly adheres to international quality standards, with ISO9001-certified quality and GMP-aligned manufacturing. Comprehensive quality control covers raw material sourcing, in-process monitoring, and finished product testing. Each batch is accompanied by a detailed Certificate of Analysis (COA) documenting physical and chemical properties, purity data (GC), density, refractive index, water content (Karl Fischer), color (APHA), and impurity profiles.
2. Product Advantages
High Purity and Consistent Quality
XinChem offers 2,4-difluorobenzylamine in multiple grades: Pharmaceutical Grade (≥99.0% purity, GC) for API synthesis and Technical Grade (≥98.0% purity, GC) for agrochemical and fine chemical applications. The product’s high purity and consistent quality minimize the risk of unwanted side reactions and impurities, making it suitable for demanding applications in drug discovery and pharmaceutical manufacturing.
Comprehensive Specifications
Key specifications include:
- Molecular Formula: C₇H₇F₂N
- Molecular Weight: 143.13 g/mol
- CAS Number: 72235-52-0
- Synonyms: 2,4-DFBA; (2,4-Difluorophenyl)methanamine
- EINECS Number: 615-496-3
- Appearance: Colorless to pale yellow clear liquid
- Purity: ≥99.0% (Pharmaceutical Grade) / ≥98.0% (Technical Grade)
- Density (25°C): 1.180 g/cm³
- Boiling Point: 70–72°C at 10 mmHg
- Flash Point: 75°C (closed cup)
- Refractive Index (nD20): 1.492
- Water Content (KF): ≤0.3%
- Color (APHA): ≤50
- Storage: Under inert gas at 2–8°C, protected from air and moisture
- Shelf Life: 12 months under recommended storage conditions
Flexible Packaging Solutions
XinChem provides a range of packaging options to accommodate diverse customer needs, from laboratory-scale quantities (1 g, 5 g, 25 g, 100 g) to industrial-scale packaging (500 g, 1 kg, 25 kg/drum, 1000 kg) and bulk shipments. Customized packaging solutions are available upon request, ensuring safe handling, storage, and transportation with appropriate protection from air and moisture.
3. Application Fields
As a versatile fluorinated building block, 2,4-Difluorobenzylamine (CAS# 72235-52-0) exhibits wide application value across multiple industries:
Pharmaceutical Synthesis (API Synthesis):
- Key intermediate for Dolutegravir (Tivicay®) and other HIV integrase inhibitors
- Building block for antiviral drugs including HCV NS3/4A inhibitors
- Precursor for anticancer agents (kinase inhibitors, PARP inhibitors)
- Intermediate for CNS drugs (fluvoxamine, voriconazole)
- Precursor for PROTAC linkers and peptide modification reagents
Agrochemical Development:
- Synthesis of modern fluorinated pesticides, including fungicides (fluopyram analogs)
- Building block for herbicides and insecticides
- Fluorine substitution improves environmental stability and target selectivity
Fine Chemical Synthesis:
- Intermediate for specialty amines, amides, Schiff bases, and heterocyclic compounds
- Building block for benzimidazoles and quinazolines with enhanced bioactivity
Materials Science:
- Production of fluorinated polymers and functional coatings
- Component in liquid crystal displays (LCDs)
4. Service Support
Technical Expertise and Customized Solutions
XinChem’s team of experienced chemists and application engineers provides full technical support throughout the customer journey—from product selection and specification development to application guidance and troubleshooting. Whether customers require optimization of synthetic routes, guidance on handling corrosive compounds, or assistance with regulatory documentation, XinChem’s technical experts are ready to help. Custom synthesis of fluorinated amines and derivatives with flexible scaling from R&D to commercial quantities is available upon request.
Global Logistics and Reliable Supply
With established supply chains serving markets across Europe, North America, Asia-Pacific, and beyond, XinChem ensures timely delivery and consistent product availability. The company’s logistics team manages all aspects of international shipping, including compliance with dangerous goods transport regulations (UN 2735, Class 8, PG III), customs clearance, and documentation, with appropriate protection from air and moisture for product stability.
Regulatory Support
XinChem provides comprehensive documentation to support regulatory compliance, including Safety Data Sheets (SDS), Certificates of Analysis (COA), and other required certificates. The company stays current with evolving regulatory requirements in major markets, including REACH, TSCA, and other regional regulations, helping customers navigate the complexities of global trade.
5. Reasons to Choose XinChem
- Professionalism: Extensive experience and deep expertise in fluorination chemistry and fine chemical synthesis.
- Quality: Rigorous quality control, high purity (≥99.0% pharmaceutical grade), ISO9001-certified quality, and GMP-aligned manufacturing.
- Reliability: Stable supply, competitive pricing, and timely delivery.
- Flexibility: Customized solutions to meet diverse customer needs, including custom synthesis of fluorinated amines and derivatives.
- Service: Responsive technical support and comprehensive documentation.
Contact us today to start your partnership with XinChem!
Website: www.xinchem.com
Email: sales1@xinchem.com
WhatsApp: +86 18049800532
Post time: Sep-20-2026