3-Pyridinesulfonyl chloride (CAS# 16133-25-8), also known as pyridine-3-sulfonyl chloride, is a reactive organosulfur compound with the molecular formula C₅H₄ClNO₂S and a molecular weight of 177.61 g/mol. Its molecular structure consists of a pyridine ring bearing a sulfonyl chloride group (-SO₂Cl) at the 3-position, conferring both electrophilic reactivity and the ability to introduce the 3-pyridylsulfonyl moiety into molecular scaffolds. The compound typically appears as a white to off-white solid with a melting point of 144°C, a boiling point of 284°C, and a flash point of 126°C. It is highly reactive and hygroscopic, soluble in DMSO (25 mg/mL), slightly soluble in chloroform and methanol, and should be stored at -20°C in sealed, moisture-proof containers. As a substituted sulfonyl chloride with high proton affinity, 3-pyridinesulfonyl chloride serves as an effective derivatizing agent and a key intermediate in the synthesis of Vonoprazan (a potassium-competitive acid blocker for gastroesophageal reflux disease), pyrimidine derivatives with antiproliferative activity against breast cancer cells, sulfonylureas, and other bioactive compounds. Based on its chemical characteristics and industrial significance, this article systematically analyzes the key properties, core application areas, global market structure, regional dynamics, regulatory landscape, and future outlook of this strategically important sulfonylating reagent.
Key Properties and Reactivity Profile
3-Pyridinesulfonyl chloride (CAS# 16133-25-8) is a substituted pyridine sulfonyl chloride whose value derives from the combination of a reactive sulfonyl chloride group and a pyridine ring.
Key physicochemical parameters include:
- Molecular Formula: C₅H₄ClNO₂S
- Molecular Weight: 177.61 g/mol
- CAS Number: 16133-25-8
- EC Number: 688-270-1
- MDL Number: MFCD03452747
- Appearance: White to off-white solid
- Melting Point: 144°C
- Boiling Point: 284°C
- Flash Point: 126°C
- Density: 1.488 g/cm³
- XLogP3-AA: 0.9
- pKa: -1.77±0.11 (predicted)
- Topological Polar Surface Area: 55.4 Ų
- Solubility: DMSO (25 mg/mL); slightly soluble in chloroform and methanol
- SMILES: C1=CC(=CN=C1)S(=O)(=O)Cl
- InChIKey: CDRNYKLYADJTMN-UHFFFAOYSA-N
- Storage: -20°C, sealed, away from moisture
- Hygroscopicity: Highly reactive and hygroscopic
The compound’s reactivity is defined by its sulfonyl chloride group, which readily undergoes nucleophilic substitution with amines to form sulfonamides, with alcohols to form sulfonate esters, and with other nucleophiles to introduce the 3-pyridylsulfonyl moiety into target molecules. The pyridine ring provides additional sites for further functionalization, making this compound a versatile building block for pharmaceutical and agrochemical synthesis.
Core Application Fields and Demand
Market demand for 3-pyridinesulfonyl chloride (CAS# 16133-25-8) is concentrated in three primary sectors: pharmaceutical intermediate manufacturing for Vonoprazan and other APIs (approximately 55–60% of global consumption), anticancer drug development and bioactive compound synthesis (approximately 25–30%), and research reagents and derivatization agents (approximately 10–15%). Its sulfonyl chloride functionality and pyridine scaffold serve as the core drivers of sustained demand growth.
In pharmaceutical intermediate manufacturing, 3-pyridinesulfonyl chloride is a key intermediate in the synthesis of Vonoprazan (TAK-438) , a first-in-class potassium-competitive acid blocker (P-CAB) approved for the treatment of gastroesophageal reflux disease, peptic ulcers, and Helicobacter pylori eradication. The compound also serves as a building block for Vonoprazan impurities and Vonoprazan fumarate intermediates. Beyond Vonoprazan, 3-pyridinesulfonyl chloride is used in the synthesis of sulfonylureas—a class of compounds with applications in diabetes management and other therapeutic areas. As an intermediate in pharmaceutical industries, the compound is employed in the production of various APIs and drug candidates. The compound is also used to synthesize pyridine-3-sulfonamide derivatives, which are important pharmacophores in medicinal chemistry.
In anticancer drug development, 3-pyridinesulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against triple-negative breast cancer cells. This application highlights the compound’s importance in oncology drug discovery, particularly for difficult-to-treat cancers. The sulfonyl chloride group enables the introduction of the 3-pyridylsulfonyl moiety into drug candidates, modulating their biological activity and pharmacokinetic properties.
In research and derivatization, 3-pyridinesulfonyl chloride serves as a derivatizing agent for the analysis of steroidal estrogens by liquid chromatography-electrospray tandem mass spectrometry (LC-ESI-MS/MS). Its high proton affinity enables effective derivatization of analytes, improving detection sensitivity and specificity in analytical chemistry applications. The compound is also used as a derivatizing agent in various analytical methods and as a biochemical assay reagent. In organic synthesis, it serves as a reagent for the preparation of sulfonamides and other functionalized pyridine derivatives.
In agrochemical and other applications, 3-pyridinesulfonyl chloride is used in the synthesis of agrochemicals and other bioactive compounds. Its sulfonyl chloride functionality enables the creation of sulfonamide-based herbicides, fungicides, and insecticides.
Major Market Participants
The global supply system for 3-pyridinesulfonyl chloride (CAS# 16133-25-8) features a pattern of “specialized fine chemical manufacturers, multinational chemical distributors, and Chinese and Indian producers serving distinct market segments.” As a specialized pharmaceutical intermediate rather than a bulk commodity, the market is characterized by a moderate number of suppliers catering to pharmaceutical R&D, API manufacturing, and academic research.
In the global research and high-purity segment, key international suppliers include Sigma-Aldrich (Merck) , offering the compound for R&D use only; Toronto Research Chemicals (LGC) , supplying high-purity research-grade material; Aladdin Scientific, offering ≥98% purity; J&K Scientific, offering 98% purity; Bide Pharmatech, offering 98% purity with batch-specific analytical data; and MedChemExpress, supplying the compound as a biochemical assay reagent. Other suppliers include VWR, GlpBio, ChemShuttle, and Smolecule. These suppliers serve the pharmaceutical, biotechnology, and academic research communities with products that meet rigorous quality specifications, typically at 95–98% purity.
In the industrial and large-scale production segment, manufacturers in India and China have emerged as dominant players in the global supply chain. Jubilant Ingrevia Limited (India) is a major manufacturer and supplier, listing the compound as an intermediate in pharmaceutical industries. Triveni Chemicals (India) offers the compound in 25 kg quantities. Chinese manufacturers include Hunan Huateng Pharmaceutical, JECI Biochem, GNEE Biotech, and Career Henan Chemical, with numerous additional suppliers operating in major chemical manufacturing regions. XinChem is a reliable manufacturer and supplier of high-purity 3-pyridinesulfonyl chloride from China, offering the compound with stringent quality standards for use in pharmaceutical synthesis, anticancer drug development, and research applications.
Regional Market Dynamics
The global 3-pyridinesulfonyl chloride market exhibits distinct regional characteristics, with production concentrated in Asia-Pacific (particularly China and India) and consumption distributed across North America, Europe, and the Asia-Pacific region, aligned with the pharmaceutical, biotechnology, and fine chemical industries in these regions. According to industry research, the 3-pyridinesulfonic acid chloride market has been analyzed with global and regional market trends from 2019–2024 and forecasts extending through 2029.
The Asia-Pacific region has emerged as a significant production hub for 3-pyridinesulfonyl chloride, with China and India hosting numerous manufacturers and suppliers including XinChem. The region’s competitive advantages include lower production costs, established chemical infrastructure, and proximity to rapidly growing pharmaceutical and agrochemical industries. Chinese and Indian suppliers offer the compound at various purity grades (typically 95–98%) and packaging options, serving both domestic and export markets. The growing pharmaceutical R&D, API manufacturing, and agrochemical sectors in China, India, Japan, and South Korea continue to drive regional consumption growth.
North America remains a key market for high-purity and research-grade 3-pyridinesulfonyl chloride, driven by demand from the pharmaceutical industry, biotechnology companies, and academic research institutions. The United States hosts numerous research organizations, pharmaceutical companies, and contract research organizations that require high-quality sulfonylating reagents for drug discovery, analytical chemistry, and API manufacturing. Sigma-Aldrich and other major distributors serve the North American market with extensive distribution networks. The region’s well-established regulatory framework and emphasis on product quality support demand for high-grade research chemicals and pharmaceutical intermediates.
Europe is characterized by stringent regulatory requirements and a strong focus on quality and sustainability in pharmaceutical and chemical research. European pharmaceutical companies, agrochemical developers, and research institutions demand high-purity sulfonylating reagents with comprehensive documentation. The region’s strong pharmaceutical and biotechnology sectors support steady demand for pyridine sulfonyl chloride derivatives.
Japan represents a specialized market where 3-pyridinesulfonyl chloride is supplied by Fujifilm Wako Pure Chemical and other distributors for pharmaceutical research, analytical chemistry, and fine chemical applications.
Regulatory and Safety Considerations
As a reactive sulfonylating reagent and pharmaceutical intermediate, 3-pyridinesulfonyl chloride (CAS# 16133-25-8) is subject to regulatory oversight in major global economies. Compliance with relevant regulations is essential for market access and trade.
GHS classification and handling: 3-Pyridinesulfonyl chloride is classified with the signal word “Danger”. Hazard statements include H314 (Causes severe skin burns and eye damage), H318 (Causes serious eye damage), and H335 (May cause respiratory irritation). The compound is classified as Skin Corrosion/Irritation Category 1B and Specific Target Organ Toxicity Category 3 (Single exposure). Precautionary statements include P260 (Do not breathe dust), P264 (Wash skin thoroughly after handling), P271 (Use only outdoors or in a well-ventilated area), and P280 (Wear protective gloves/protective clothing/eye protection/face protection). In case of exposure, P301+P330+P331 (IF SWALLOWED: Rinse mouth; do NOT induce vomiting), P303+P361+P353 (IF ON SKIN: Take off immediately all contaminated clothing; rinse skin with water/shower), P304+P340+P310 (IF INHALED: Remove person to fresh air; immediately call a POISON CENTER/doctor), and P305+P351+P338+P310 (IF IN EYES: Rinse cautiously with water for several minutes; continue rinsing; immediately call a POISON CENTER/doctor).
Storage and handling: The compound is highly reactive and hygroscopic. It should be stored in a sealed, airtight container in a cool, dry place, away from moisture and light. Protection from humidity and air is required to prevent degradation. Storage temperature should be maintained below 25°C, with -20°C recommended for long-term storage. Personal protective equipment including protective gloves, protective clothing, eye protection, and face protection should be worn during handling, and operations should be conducted in a well-ventilated area or fume hood.
Regulatory compliance: In the European Union, the compound must comply with REACH registration requirements and CLP classification under Regulation (EC) No 1272/2008 for import and use. Manufacturers and suppliers must provide comprehensive Safety Data Sheets (SDS) and maintain appropriate documentation. In the United States, the compound is regulated under the OSHA Hazard Communication Standard (29 CFR 1910.1200) and is intended for R&D use only, not for pharmaceutical, household, or other uses.
Transport information: 3-Pyridinesulfonyl chloride requires proper packaging, labeling, and documentation for international shipping in compliance with the International Maritime Dangerous Goods Code (IMDG Code) and other transport regulations. The compound is typically shipped in sealed containers under inert atmosphere with appropriate hazardous material handling.
Future Outlook
The market outlook for 3-pyridinesulfonyl chloride is positive, supported by several key growth drivers across its major application segments. While the compound remains a relatively specialized pharmaceutical intermediate, its essential role in Vonoprazan synthesis, anticancer drug development, and sulfonamide chemistry positions it for steady growth in the coming years.
Key growth drivers include:
- Expansion of the Vonoprazan market: The growing global adoption of Vonoprazan (TAK-438) for gastroesophageal reflux disease, peptic ulcers, and Helicobacter pylori eradication drives demand for the key intermediate. As Vonoprazan gains market share over traditional proton pump inhibitors, demand for 3-pyridinesulfonyl chloride is expected to increase correspondingly.
- Growth in anticancer drug development: The compound’s role in synthesizing pyrimidine derivatives with anti-proliferative activity against triple-negative breast cancer cells positions it as a valuable building block in oncology drug discovery.
- Increasing demand for sulfonylureas and sulfonamide drugs: The continued use of sulfonylureas in diabetes management and the development of novel sulfonamide-based therapeutics support steady demand for sulfonylating reagents.
- Expansion of pharmaceutical R&D and API manufacturing: Increasing investment in drug discovery and development, particularly in Asia-Pacific, drives demand for high-quality pharmaceutical intermediates and building blocks.
- Growth in analytical chemistry applications: The compound’s role as a derivatizing agent for steroidal estrogen analysis by LC-MS/MS supports demand from analytical and bioanalytical laboratories.
Challenges and considerations:
- Regulatory compliance: Increasingly stringent pharmaceutical and chemical regulations may require ongoing investment in quality systems and documentation.
- Hazardous material handling: The compound’s corrosive and reactive nature (H314, H318, H335) requires specialized handling, packaging, and safety procedures that may increase costs.
- Hygroscopicity and stability: The compound’s hygroscopic nature and sensitivity to moisture require careful storage and handling, which may limit its use in some applications.
- Competition from alternative sulfonylating reagents: The market faces competition from other pyridinesulfonyl chloride isomers and alternative sulfonylation methodologies.
To succeed in this evolving market landscape, suppliers must focus on product quality (particularly purity, moisture content, and batch-to-batch consistency), supply chain reliability, regulatory compliance, and responsive customer service. Companies that can offer high-purity products, flexible packaging options, and technical support for pharmaceutical, agrochemical, and research applications will be well-positioned to capture growing demand.
Shanghai XinChem Co., Ltd. (XinChem)
As a world-leading supplier of organic chemicals and pharmaceutical intermediates, Shanghai XinChem Co., Ltd. (XinChem) is dedicated to meeting the innovative needs of the pharmaceutical, agrochemical, biotechnology, and fine chemical industries. Leveraging extensive experience and advanced manufacturing capabilities, XinChem provides high-quality 3-Pyridinesulfonyl Chloride (CAS# 16133-25-8) to customers worldwide. As a trusted manufacturer and supplier based in China, XinChem combines competitive pricing, reliable supply, and exceptional service to establish itself as a preferred partner for research institutions, pharmaceutical companies, and industrial manufacturers seeking this versatile sulfonylating reagent and pharmaceutical intermediate.
1. Technical Advantages
Advanced Synthesis and Purification Processes
XinChem utilizes state-of-the-art manufacturing facilities and rigorous quality control measures to ensure the purity, consistency, and safety of its 3-pyridinesulfonyl chloride products. The production process incorporates established synthetic routes—including the chlorosulfonation of pyridine or the reaction of pyridine-3-sulfonic acid with phosphorus pentachloride or thionyl chloride—enabling the delivery of products with purity ≥98% to meet diverse application requirements. Strict process control ensures consistent product quality, minimal impurities (especially moisture content, which is critical for sulfonyl chloride stability), and batch-to-batch reproducibility, providing customers with reliable performance in pharmaceutical synthesis, anticancer drug development, and research applications.
Full-Chain Quality Control
The production process strictly adheres to international quality standards, with comprehensive quality control covering raw material sourcing, in-process monitoring, and finished product testing. Each batch is accompanied by a detailed Certificate of Analysis (COA) documenting physical and chemical properties, purity data (HPLC/GC), melting point, and impurity profiles. This commitment to quality ensures that XinChem’s 3-pyridinesulfonyl chloride meets the stringent requirements of pharmaceutical R&D, API manufacturing, and research applications.
2. Product Advantages
High Purity and Consistent Quality
XinChem offers 3-pyridinesulfonyl chloride with purity ≥98% (HPLC/GC), ensuring optimal performance in pharmaceutical synthesis, anticancer drug development, and research applications. The product’s high purity minimizes the risk of unwanted side reactions and impurities, making it suitable for demanding applications in drug discovery, API manufacturing, and analytical chemistry.
Comprehensive Specifications
Key specifications include:
- Molecular Formula: C₅H₄ClNO₂S
- Molecular Weight: 177.61 g/mol
- CAS Number: 16133-25-8
- Synonyms: Pyridine-3-sulfonyl chloride; 3-Pyridinesulfonyl chloride; Pyridine-3-sulfonyl chloride hydrochloride
- MDL Number: MFCD03452747
- Appearance: White to off-white solid
- Purity: ≥98% (HPLC/GC)
- Melting Point: 144°C
- Storage: -20°C, sealed, away from moisture
Flexible Packaging Solutions
XinChem provides a range of packaging options to accommodate diverse customer needs, from laboratory-scale quantities (grams) to industrial-scale packaging (kilograms) and bulk shipments. Customized packaging solutions are available upon request, ensuring safe handling, storage, and transportation with appropriate moisture protection.
3. Application Fields
As a versatile sulfonylating reagent and pharmaceutical intermediate, 3-Pyridinesulfonyl Chloride (CAS# 16133-25-8) exhibits wide application value across multiple industries:
Pharmaceutical Synthesis:
- Key intermediate for Vonoprazan (TAK-438), a first-in-class potassium-competitive acid blocker
- Building block for Vonoprazan impurities and Vonoprazan fumarate intermediates
- Synthesis of sulfonylureas for diabetes management
- Production of various APIs and drug candidates
Anticancer Drug Development:
- Reagent for synthesizing pyrimidine derivatives with anti-proliferative activity against triple-negative breast cancer cells
- Building block for oncology drug discovery programs
Research and Analytical Chemistry:
- Derivatizing agent for steroidal estrogen analysis by LC-ESI-MS/MS
- Biochemical assay reagent
- Reagent for organic synthesis and functional group modification
Agrochemical and Other Applications:
- Synthesis of agrochemicals and bioactive compounds
- Preparation of sulfonamide derivatives
4. Service Support
Technical Expertise and Customized Solutions
XinChem’s team of experienced chemists and application engineers provides full technical support throughout the customer journey—from product selection and specification development to application guidance and troubleshooting. Whether customers require optimization of sulfonylation reaction conditions, guidance on handling hygroscopic compounds, or assistance with regulatory documentation, XinChem’s technical experts are ready to help. Custom synthesis and contract manufacturing with flexible scaling from R&D to commercial quantities are available upon request.
Global Logistics and Reliable Supply
With established supply chains serving markets across Europe, North America, Asia-Pacific, and beyond, XinChem ensures timely delivery and consistent product availability. The company’s logistics team manages all aspects of international shipping, including compliance with dangerous goods transport regulations, customs clearance, and documentation.
Regulatory Support
XinChem provides comprehensive documentation to support regulatory compliance, including Safety Data Sheets (SDS), Certificates of Analysis (COA), and other required certificates. The company stays current with evolving regulatory requirements in major markets, including REACH, TSCA, OSHA, and other regional regulations, helping customers navigate the complexities of global trade.
5. Reasons to Choose XinChem
- Professionalism: Extensive experience and deep expertise in pharmaceutical intermediate synthesis and supply.
- Quality: Rigorous quality control, high purity (≥98%), and adherence to international standards.
- Reliability: Stable supply, competitive pricing, and timely delivery.
- Flexibility: Customized solutions to meet diverse customer needs, including custom synthesis and packaging.
- Service: Responsive technical support and comprehensive documentation.
Contact us today to start your partnership with XinChem!
Website: www.xinchem.com
Email: sales1@xinchem.com
WhatsApp: +86 18049800532
Post time: Sep-07-2026