Pimavanserin(CAS#706779-91-1)

pharmachologic effect
Receptor selectivity: is a selective, potent serotonin 2A (5-HT2A) receptor inverse agonist with approximately 40-fold greater affinity for the 5-HT2A receptor than for the 5-HT2C receptor.
Mechanism of disease treatment: It acts by selectively inhibiting the 5-HT2a receptor, which plays a key role in the occurrence of hallucinations and delusions, and can be used to treat psychiatric symptoms such as delusions, hallucinations, and delusions associated with Parkinson's disease, and can also inhibit amyloid β protein production, which has an ameliorating effect on anxiety-related behaviors and memory in mouse models of Alzheimer's disease.
Clinical application
Treatment of psychiatric symptoms of Parkinson's disease: Approved by the U.S. Food and Drug Administration on April 29, 2016, for the treatment of psychiatric symptoms associated with Parkinson's disease, it has a lower incidence of side effects, especially extrapyramidal symptoms, compared with other antipsychotic drugs.
Dementia-related psychosis therapeutic potential: In a clinical trial called "harmony", it has shown the potential to significantly reduce the risk of relapse of dementia-related psychosis.

Application
Pimavanserin (Nuplazid®, ACP-103) is a first‑in‑class selective serotonin 5‑HT2A receptor inverse agonist with nanomolar potency (Ki = 0.087 nM). As the only FDA‑approved drug for hallucinations and delusions associated with Parkinson’s disease psychosis (PDP), it uniquely relieves psychotic symptoms without blocking dopamine D2 receptors, thereby avoiding worsening of motor function. The mechanism is thought to involve inverse agonism at 5‑HT2A receptors, with a long plasma half‑life (∼57 h) enabling once‑daily oral dosing. Beyond PDP, pimavanserin is being investigated for dementia‑related psychosis, Alzheimer’s disease agitation, and other neuropsychiatric conditions. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high‑purity pimavanserin (base and tartrate salt) with full regulatory support. Contact us today for a competitive quote and reliable global supply.